利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

40 条记录 (耗时 0.037 秒)

    Method to enhance aqueous solubility of poorly soluble actives
    2.
    发明授权
    Method to enhance aqueous solubility of poorly soluble actives 有权
    提高难溶性活性物质的水溶性的方法

    公开(公告)号：US08497303B2

    公开(公告)日：2013-07-30

    申请号：US12810962

    申请日：2009-01-05

    申请人： David B. Wurn ,  David A. Wilson ,  Bruce A. Barner ,  Cynthia L. Rand ,  Matthew D. Miller ,  Michael J. Johnson

    发明人： David B. Wurn ,  David A. Wilson ,  Bruce A. Barner ,  Cynthia L. Rand ,  Matthew D. Miller ,  Michael J. Johnson

    IPC分类号： A61K9/08 ,  A61K47/10 ,  A61K31/192 ,  A61K31/167

    CPC分类号： A61K31/167 ,  A61K9/08 ,  A61K31/192 ,  A61K47/10

    摘要： A method to enhance solubility of an active compound comprises combining an active compound, having an aqueous solubility that is less than or equal to about 10 mg/mL, and an amount of methoxypolyethylene glycol that is sufficient to increase the aqueous solubility of the active compound. Enhancement of aqueous solubility for this combination may be significantly greater than that of an active compound in combination with an equivalent amount of polyethylene glycol. Particularly enhanced solubility is shown where a small amount of water is also included. The invention may be used in a wide variety of applications, such as for pharmaceutical, agricultural, antimicrobial, and personal care products.

    摘要翻译： 提高活性化合物的溶解度的方法包括组合具有小于或等于约10mg / mL的水溶解度的活性化合物和足以提高活性化合物的水溶性的甲氧基聚乙二醇的量 。 该组合的水溶性的增强可以显着大于活性化合物与等量的聚乙二醇的组合。 显示特别增加的溶解度，其中也包括少量的水。 本发明可以用于各种各样的应用，例如用于制药，农业，抗微生物和个人护理产品。

    Alkylene oxide-capped secondary alcohol alkoxylates useful as surfactants
    8.
    发明授权
    Alkylene oxide-capped secondary alcohol alkoxylates useful as surfactants 有权
    用作表面活性剂的环氧烷封端的仲醇烷氧基化物

    公开(公告)号：US08334323B2

    公开(公告)日：2012-12-18

    申请号：US12808936

    申请日：2008-12-23

    申请人： Pierre T. Varineau ,  Wanglin Yu ,  Kara S. Weber ,  Cynthia L. Rand

    发明人： Pierre T. Varineau ,  Wanglin Yu ,  Kara S. Weber ,  Cynthia L. Rand

    IPC分类号： C07C43/13 ,  C07C41/01 ,  C11D1/722 ,  C08K5/06 ,  A61K47/08 ,  C09D7/12 ,  C09D11/02 ,  C09K8/60 ,  C10M105/18 ,  D21H17/06 ,  A61P43/00

    CPC分类号： C08G65/2609 ,  C07C41/03 ,  C07C43/11

    摘要： Disclosed are compositions of the formula wherein R1 and R2 are each independently hydrogen or a linear or branched alkyl group containing from (1) to about (18) carbon atoms, provided that R1 and R2 together contain from about (8) to about (18) carbon atoms, and further provided that less than about 10 mole percent of R1 or R2 is hydrogen; R3 is hydrogen or an alkyl radical containing from (1) to about (6) carbon atoms; R4 and R5 are each independently hydrogen or an alkyl radical containing from (2) to about (6) carbon atoms, provided that R4 and R5 together contain from (2) to about (6) carbon atoms; m is an average value ranging from (0) to about (10), and n is an average value ranging from about (3) to (about 40), provided that the group containing m and the group containing n may be exchanged with one another as to position; and z is an average value ranging from about (0.5) to about (5). These compositions are conveniently prepared by a process including at least two steps and are useful as surfactants.

    摘要翻译： 公开了下式的组合物，其中R 1和R 2各自独立地为氢或含有（1）至约（18）个碳原子的直链或支链烷基，条件是R 1和R 2一起含有约（8）至约（18 ）碳原子，并且还提供少于约10摩尔％的R 1或R 2是氢; R3是氢或含有（1） - 约（6）个碳原子的烷基; R 4和R 5各自独立地为氢或含有（2）至约（6）个碳原子的烷基，条件是R 4和R 5一起含有（2）至约（6）个碳原子; m是从（0）到约（10）的平均值，n是约（3）至（约40）的平均值，条件是含有m和含有n的基团的基团可以与一个 另一个位置; z为约（0.5）〜（5）的平均值。 这些组合物通过包括至少两个步骤的方法方便地制备，并且可用作表面活性剂。