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11.发明申请Multi-Arm Polypeptide-Poly(ethylene glycol) Block Copolymers as Drug Delivery Vehicles 有权多臂多肽 - 聚（乙二醇）嵌段共聚物作为药物递送载体公开(公告)号：US20110237747A1
公开(公告)日：2011-09-29
申请号：US13152144
申请日：2011-06-02
申请人： Xuan Zhao , Zhongxu Ren , Kazunori Emoto
发明人： Xuan Zhao , Zhongxu Ren , Kazunori Emoto
IPC分类号： C08G63/91 , C08G65/333
CPC分类号： A61K9/5146 , A61K47/34 , A61K47/60 , A61K47/64 , C08G65/329 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/26
摘要： The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.
摘要翻译： 本发明提供了用于递送各种生物活性剂的多臂嵌段共聚物。 本发明的共聚物含有中心核，多个（3个或更多个）共聚物臂可从中心芯延伸。 每个共聚物臂具有内部多肽片段和外部亲水性聚合物片段。 因此，共聚物的总体结构包括内核区域，其包含中心核心和内部多肽区段，而外核区域本质上是亲水性的。 本发明的多臂共聚物特别可用于递送可以包埋在内芯区内的生物活性剂。
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12.发明申请Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles 有权多臂多肽 - 聚（乙二醇）嵌段共聚物作为药物递送载体公开(公告)号：US20080069902A1
公开(公告)日：2008-03-20
申请号：US11985443
申请日：2007-11-14
申请人： Xuan Zhao , Zhongxu Ren , Kazunori Emoto
发明人： Xuan Zhao , Zhongxu Ren , Kazunori Emoto
IPC分类号： A61K47/48 , A61K31/337 , A61K31/405 , A61K31/505 , A61K33/24
CPC分类号： A61K9/5146 , A61K47/34 , A61K47/60 , A61K47/64 , C08G65/329 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/26
摘要： The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.
摘要翻译： 本发明提供了用于递送各种生物活性剂的多臂嵌段共聚物。 本发明的共聚物含有中心核，多个（3个或更多个）共聚物臂可从中心芯延伸。 每个共聚物臂具有内部多肽片段和外部亲水性聚合物片段。 因此，共聚物的总体结构包括内核区域，其包含中心核心和内部多肽区段，而外核区域本质上是亲水性的。 本发明的多臂共聚物特别可用于递送可以包埋在内芯区内的生物活性剂。
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13.发明授权Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles 有权多臂多肽 - 聚（乙二醇）嵌段共聚物作为药物递送载体公开(公告)号：US07316811B2
公开(公告)日：2008-01-08
申请号：US10746567
申请日：2003-12-24
申请人： Xuan Zhao , Zhongxu Ren , Kazunori Emoto
发明人： Xuan Zhao , Zhongxu Ren , Kazunori Emoto
IPC分类号： A61K31/74
CPC分类号： A61K9/5146 , A61K47/34 , A61K47/60 , A61K47/64 , C08G65/329 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/26
摘要： The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.
摘要翻译： 本发明提供了用于递送各种生物活性剂的多臂嵌段共聚物。 本发明的共聚物含有中心核，多个（3个或更多个）共聚物臂可从中心芯延伸。 每个共聚物臂具有内部多肽片段和外部亲水性聚合物片段。 因此，共聚物的总体结构包括内核区域，其包含中心核心和内部多肽区段，而外核区域本质上是亲水性的。 本发明的多臂共聚物特别可用于递送可以包埋在内芯区内的生物活性剂。
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公开(公告)号：US08853247B2
公开(公告)日：2014-10-07
申请号：US12739605
申请日：2008-10-31
CPC分类号： C07D233/94 , A61K47/48215 , A61K47/60
摘要： The invention provides (among other things) small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer.
摘要翻译： 本发明提供了（尤其是）通过共价连接水溶性低聚物化学改性的小分子药物。
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15.发明授权Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles 有权多臂多肽 - 聚（乙二醇）嵌段共聚物作为药物递送载体公开(公告)号：US08323632B2
公开(公告)日：2012-12-04
申请号：US13152144
申请日：2011-06-02
申请人： Xuan Zhao , Zhongxu Ren , Kazunori Emoto
发明人： Xuan Zhao , Zhongxu Ren , Kazunori Emoto
IPC分类号： A61K31/79
CPC分类号： A61K9/5146 , A61K47/34 , A61K47/60 , A61K47/64 , C08G65/329 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/26
摘要： The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.
摘要翻译： 本发明提供了用于递送各种生物活性剂的多臂嵌段共聚物。 本发明的共聚物含有中心核，多个（3个或更多个）共聚物臂可从中心芯延伸。 每个共聚物臂具有内部多肽片段和外部亲水性聚合物片段。 因此，共聚物的总体结构包括内核区域，其包含中心核心和内部多肽区段，而外核区域本质上是亲水性的。 本发明的多臂共聚物特别可用于递送可以包埋在内芯区内的生物活性剂。
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公开(公告)号：US08748648B2
公开(公告)日：2014-06-10
申请号：US12674139
申请日：2008-09-03
IPC分类号： C07C255/00
CPC分类号： A61K31/4422 , A61K31/4418 , A61K47/48215 , A61K47/60 , C07C255/43 , C07D211/90 , C07D281/10 , C07D413/04 , C07D417/04
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
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公开(公告)号：US20120004242A1
公开(公告)日：2012-01-05
申请号：US12864481
申请日：2009-01-22
IPC分类号： A61K31/495 , A61P25/04 , C07D241/04
CPC分类号： A61K31/495 , A61K47/48215 , A61K47/60 , C07D241/04
摘要： The invention relates to (among other things) oligomer-diarylpiperazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated diarylpiperazine compounds.
摘要翻译： 本发明涉及（尤其是）低聚物 - 二芳基哌嗪共轭物和相关化合物。 本发明的缀合物当通过任何多种施用途径施用时，显示出优于先前施用的未共轭二芳基哌嗪化合物的优点。
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公开(公告)号：US08685979B2
公开(公告)日：2014-04-01
申请号：US12864481
申请日：2009-01-22
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： A61K31/495 , A61K47/48215 , A61K47/60 , C07D241/04
摘要： The invention relates to (among other things) oligomer-diarylpiperazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated diarylpiperazine compounds.
摘要翻译： 本发明涉及（尤其是）低聚物 - 二芳基哌嗪共轭物和相关化合物。 本发明的缀合物当通过任何多种施用途径施用时，显示出优于先前施用的未共轭二芳基哌嗪化合物的优点。
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19.发明授权Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles 有权多臂多肽 - 聚（乙二醇）嵌段共聚物作为药物递送载体公开(公告)号：US07976834B2
公开(公告)日：2011-07-12
申请号：US11985443
申请日：2007-11-14
申请人： Xuan S. Zhao , Zhongxu Ren , Kazunori Emoto
发明人： Xuan S. Zhao , Zhongxu Ren , Kazunori Emoto
IPC分类号： A61K31/74 , A61K31/765
CPC分类号： A61K9/5146 , A61K47/34 , A61K47/60 , A61K47/64 , C08G65/329 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/26
摘要： The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.
摘要翻译： 本发明提供了用于递送各种生物活性剂的多臂嵌段共聚物。 本发明的共聚物含有中心核，多个（3个或更多个）共聚物臂可从中心芯延伸。 每个共聚物臂具有内部多肽片段和外部亲水性聚合物片段。 因此，共聚物的总体结构包括内核区域，其包含中心核心和内部多肽区段，而外核区域本质上是亲水性的。 本发明的多臂共聚物特别可用于递送可以包埋在内芯区内的生物活性剂。
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公开(公告)号：US20110098273A1
公开(公告)日：2011-04-28
申请号：US12674139
申请日：2008-09-03
IPC分类号： A61K31/554 , C07D213/80 , A61K31/4418 , C07D417/02 , A61K31/4439 , C07D413/02 , C07C255/00 , A61K31/135 , C07D281/02 , A61P43/00
CPC分类号： A61K31/4422 , A61K31/4418 , A61K47/48215 , A61K47/60 , C07C255/43 , C07D211/90 , C07D281/10 , C07D413/04 , C07D417/04
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
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