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公开(公告)号：US09090535B2
公开(公告)日：2015-07-28
申请号：US13992587
申请日：2011-12-09
IPC分类号： C07C217/52 , C07C217/54 , A61K31/137 , A61P25/08 , A61P25/24
CPC分类号： C07C217/52
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特性不同的特征。
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公开(公告)号：US08772479B2
公开(公告)日：2014-07-08
申请号：US13319824
申请日：2010-05-13
IPC分类号： C07D253/075 , A61K31/53 , A61P25/08
CPC分类号： C07D253/075 , A61K31/53 , A61K47/60
摘要： The invention relates to (among other things) oligomer-containing substituted aromatic triazine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
摘要翻译： 本发明涉及（尤其是）含低聚物的取代的芳族三嗪化合物。 当通过任何多种施用途径给药时，本发明的化合物相对于缺乏寡聚体的相应化合物显示出一个或多个优点。
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公开(公告)号：US08575196B2
公开(公告)日：2013-11-05
申请号：US13386327
申请日：2010-07-21
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US20120264775A1
公开(公告)日：2012-10-18
申请号：US13426521
申请日：2012-03-21
IPC分类号： C07D489/08 , A61P25/00 , A61K31/485
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US20120184581A1
公开(公告)日：2012-07-19
申请号：US13386327
申请日：2010-07-21
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学改性的化合物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的化合物的特征不同的特征。
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公开(公告)号：US20120122871A1
公开(公告)日：2012-05-17
申请号：US13319824
申请日：2010-05-13
IPC分类号： A61K31/53 , A61P25/08 , A61P25/04 , C07D253/075
CPC分类号： C07D253/075 , A61K31/53 , A61K47/60
摘要： The invention relates to (among other things) oligomer-containing substituted aromatic triazine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
摘要翻译： 本发明涉及（尤其是）含低聚物的取代的芳族三嗪化合物。 当通过任何多种施用途径给药时，本发明的化合物显示出相对于缺乏寡聚物的相应化合物的一个或多个优点。
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公开(公告)号：US20110039797A1
公开(公告)日：2011-02-17
申请号：US12918780
申请日：2009-02-20
IPC分类号： A61K31/7056 , C07H19/056 , C07H19/044 , A61P31/12
CPC分类号： A61K47/48215 , A61K31/7056 , A61K47/60 , C07H19/056
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。
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公开(公告)号：US20100184989A1
公开(公告)日：2010-07-22
申请号：US12530438
申请日：2008-03-12
申请人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
发明人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
IPC分类号： A61K47/48
CPC分类号： C08G65/3315 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08L2203/02
摘要： The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
摘要翻译： 本发明提供了通过共价连接由水溶性低聚物组合物获得的水溶性低聚物进行化学修饰的小分子药物的制备方法。 通过修饰合成途径产生这样的药物，以将低聚物连接到中间体化合物，然后完成合成路径。
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公开(公告)号：US08440687B2
公开(公告)日：2013-05-14
申请号：US13426521
申请日：2012-03-21
IPC分类号： A61K31/485 , C07D489/08
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US08389759B2
公开(公告)日：2013-03-05
申请号：US12530424
申请日：2008-03-12
CPC分类号： C07C69/736 , A61K47/60
摘要： The invention provides anticholinergic agents that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different as compared to the characteristics of the anticholinergic agent not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的抗胆碱能药。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的抗胆碱能药物的特征相比不同的特征。
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