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公开(公告)号：US20110098273A1
公开(公告)日：2011-04-28
申请号：US12674139
申请日：2008-09-03
IPC分类号： A61K31/554 , C07D213/80 , A61K31/4418 , C07D417/02 , A61K31/4439 , C07D413/02 , C07C255/00 , A61K31/135 , C07D281/02 , A61P43/00
CPC分类号： A61K31/4422 , A61K31/4418 , A61K47/48215 , A61K47/60 , C07C255/43 , C07D211/90 , C07D281/10 , C07D413/04 , C07D417/04
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
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公开(公告)号：US08748648B2
公开(公告)日：2014-06-10
申请号：US12674139
申请日：2008-09-03
IPC分类号： C07C255/00
CPC分类号： A61K31/4422 , A61K31/4418 , A61K47/48215 , A61K47/60 , C07C255/43 , C07D211/90 , C07D281/10 , C07D413/04 , C07D417/04
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
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公开(公告)号：US20100184989A1
公开(公告)日：2010-07-22
申请号：US12530438
申请日：2008-03-12
申请人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
发明人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
IPC分类号： A61K47/48
CPC分类号： C08G65/3315 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08L2203/02
摘要： The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
摘要翻译： 本发明提供了通过共价连接由水溶性低聚物组合物获得的水溶性低聚物进行化学修饰的小分子药物的制备方法。 通过修饰合成途径产生这样的药物，以将低聚物连接到中间体化合物，然后完成合成路径。
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公开(公告)号：US08440687B2
公开(公告)日：2013-05-14
申请号：US13426521
申请日：2012-03-21
IPC分类号： A61K31/485 , C07D489/08
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US08389759B2
公开(公告)日：2013-03-05
申请号：US12530424
申请日：2008-03-12
CPC分类号： C07C69/736 , A61K47/60
摘要： The invention provides anticholinergic agents that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different as compared to the characteristics of the anticholinergic agent not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的抗胆碱能药。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的抗胆碱能药物的特征相比不同的特征。
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公开(公告)号：US08466276B2
公开(公告)日：2013-06-18
申请号：US12918780
申请日：2009-02-20
IPC分类号： C07H19/056 , A01N43/04 , A61K31/70
CPC分类号： A61K47/48215 , A61K31/7056 , A61K47/60 , C07H19/056
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
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公开(公告)号：US20110112183A1
公开(公告)日：2011-05-12
申请号：US12989074
申请日：2009-04-23
IPC分类号： A61K31/352 , C07D407/12 , A61P29/00 , A61P11/06
CPC分类号： A61K47/48215 , A61K31/353 , A61K47/60
摘要： The invention provides oligomer-bis-chromonyl compound conjugates. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
摘要翻译： 本发明提供低聚物 - 双 - 色酮化合物共轭物。 当通过任何多种施用途径施用时，本发明的缀合物显示出优于先前给予的化合物的优点。
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公开(公告)号：US20100168232A1
公开(公告)日：2010-07-01
申请号：US12530424
申请日：2008-03-12
IPC分类号： A61K31/216 , C07C69/675 , A61P13/00 , A61P13/06
CPC分类号： C07C69/736 , A61K47/60
摘要： The invention provides anticholinergic agents that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different as compared to the characteristics of the anticholinergic agent not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的抗胆碱能药。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的抗胆碱能药物的特征相比不同的特征。
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公开(公告)号：US09226970B2
公开(公告)日：2016-01-05
申请号：US13580580
申请日：2011-02-22
IPC分类号： A61K31/497 , A61K47/48
CPC分类号： A61K31/496 , A61K47/60
摘要： Disclosed are compounds comprising diaromatic substituted compound residues, namely the anti-viral (anti-HIV) drug delavirdine, covalently attached via a linkage to water-soluble, non-peptidic oligomers, specifically to poly(ethylene glycol) (PEG) oligomers. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over non-oligomer modified diaromatic substituted compounds.
摘要翻译： 公开了包含二芳基取代的化合物残基的化合物，即通过连接至水溶性非肽寡聚物，特别是与聚（乙二醇）（PEG）低聚物共价连接的抗病毒（抗HIV）药物地拉夫定。 本发明的化合物当通过任何多种施用途径给药时，显示出优于非低聚物修饰的二芳基取代化合物的优点。
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公开(公告)号：US09095621B2
公开(公告)日：2015-08-04
申请号：US12989074
申请日：2009-04-23
IPC分类号： C07D311/00 , A61K31/35 , A61K47/48
CPC分类号： A61K47/48215 , A61K31/353 , A61K47/60
摘要： The invention provides oligomer-bis-chromonyl compound conjugates. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
摘要翻译： 本发明提供低聚物 - 双 - 色酮化合物共轭物。 当通过任何多种施用途径施用时，本发明的缀合物显示出优于先前给予的化合物的优点。
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