公开(公告)号：US20160222366A1

公开(公告)日：2016-08-04

申请号：US14782205

申请日：2015-09-25

Applicant: XYLECO, INC.

Inventor： Marshall Medoff ,  Natasha Kreder ,  James Lynch ,  Sean Landry ,  Aiichiro Yoshida ,  Desiree Pangilinan ,  Thomas Craig Masterman

IPC: C12N9/42 ,  C12P19/14 ,  C12P19/02

CPC classification number: C12N9/2445 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01021

Abstract: The present invention relates to mixtures comprising a polypeptide or a plurality of polypeptides having biomass-degrading activity that is solubilized from an inclusion body, and retaining biomass-degrading activity, and methods for producing and using the same. The invention described herein provides methods for increasing the yield of recombinant protein with biomass-degrading activity that can be isolated from host cells.

Abstract translation: 本发明涉及包含多肽或多肽的混合物，其具有从包涵体溶解的生物降解活性，并保持生物降解活性，以及​​生产和使用该生物降解活性的方法。 本文描述的本发明提供了用于从宿主细胞分离的用生物降解活性提高重组蛋白的产量的方法。