公开(公告)号：US20240294961A1

公开(公告)日：2024-09-05

申请号：US18460258

申请日：2023-09-01

申请人： SixRing Inc.

发明人： Alejandra ENRIQUEZ ,  Julie GREER ,  Markus WEISSENBERGER ,  Alexandria OSTASZEWSKI

IPC分类号： C12P19/12 ,  C12N9/42

CPC分类号： C12P19/12 ,  C12N9/244 ,  C12N9/2445 ,  C12Y302/01006 ,  C12Y302/01021

摘要： A process to hydrolyze cellulose into cellobiose comprises providing a reaction vessel and providing an inoculum of a bacteria or fungus capable of expressing one or more endo or exo-β-glucanase into reaction vessel. The bacterium or fungus is exposed to a source of cellulose having a kappa number of less than 10 and a hemicellulose content of less than 15% in an aqueous medium of pH between 5 and 9 at a temperature ranging from 20° C. to 40° C. for a period of time ranging from 1 to 30 days. The cellobiose is exposed to a bacterium or fungi or yeast, or combination which converts cellobiose to glucose or ethanol.

公开(公告)号：US20240182936A1

公开(公告)日：2024-06-06

申请号：US18553817

申请日：2022-04-05

申请人： DSM IP Assets B.V.

发明人： Maaike APPELDOORN ,  Wouter KROES

IPC分类号： C12P19/02 ,  C12N9/34 ,  C12N9/42 ,  C12P19/14

CPC分类号： C12P19/02 ,  C12N9/2428 ,  C12N9/2437 ,  C12N9/2445 ,  C12P19/14 ,  C12P2201/00 ,  C12P2203/00 ,  C12Y302/01003 ,  C12Y302/01021 ,  C12Y302/01091

摘要： The application relates to an enzyme composition, a process for the preparation thereof and the use of the enzyme composition in enzymatic hydrolysis.

公开(公告)号：US20240132864A1

公开(公告)日：2024-04-25

申请号：US18267278

申请日：2021-12-13

申请人： Clariant Produkte (Deutschland) GmbH

发明人： Christian GAMAUF ,  Jörg CLAREN

IPC分类号： C12N9/42 ,  C12P21/00

CPC分类号： C12N9/2445 ,  C12P21/00 ,  C12Y302/01021 ,  C12P2203/00

摘要： The present invention relates to a process for the production of a filamentous fungus whole broth enzyme composition with low biomass formation and high protein yield, a genetically modified filamentous fungus cell for production of the whole broth enzyme composition, the use of such a genetically modified filamentous fungus cell for the production of the filamentous fungus whole broth enzyme composition with low biomass formation and high protein yield and a filamentous fungus whole broth enzyme composition produced by such a method.

公开(公告)号：US20240131193A1

公开(公告)日：2024-04-25

申请号：US18161598

申请日：2023-01-30

申请人： Modema TX, Inc.

发明人： Antonin DE FOUGEROLLES ,  Justin GUILD

IPC分类号： A61K48/00 ,  A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K31/7115 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/45 ,  A61K38/48 ,  A61K47/54 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/28 ,  C07K16/40 ,  C12N9/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/24 ,  C12N9/42 ,  C12N9/64 ,  C12N9/68 ,  C12N9/88 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00

CPC分类号： A61K48/0066 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7115 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0075 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/43595 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/4723 ,  C07K14/4746 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/5418 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/40 ,  C12N9/0069 ,  C12N9/0091 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/6435 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/6443 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y603/02019 ,  A61K38/00 ,  Y02A50/30

摘要： The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.

公开(公告)号：US20240117399A1

公开(公告)日：2024-04-11

申请号：US18267275

申请日：2021-12-13

申请人： Clariant Produkte (Deutschland) GmbH

发明人： Christian GAMAUF ,  Jörg CLAREN

IPC分类号： C12P21/00 ,  C12N9/42

CPC分类号： C12P21/00 ,  C12N9/2445 ,  C12Y302/01021 ,  C12P2203/00

摘要： The present invention relates to a process for the production of a filamentous fungus whole broth enzyme composition with low biomass formation and high protein yield, a genetically modified filamentous fungus cell for production of the whole broth enzyme composition, the use of such a genetically modified filamentous fungus cell for the production of the filamentous fungus whole broth enzyme composition with low biomass formation and high protein yield and a filamentous fungus whole broth enzyme composition produced by such a method.

公开(公告)号：US11857580B2

公开(公告)日：2024-01-02

申请号：US16850587

申请日：2020-04-16

申请人： MEDIOGEN CO., LTD. ,  Nam Soo Paek

发明人： Nam-Soo Paek ,  Chang Ho Kang

IPC分类号： A61K35/747 ,  A61P31/04 ,  C12N9/18 ,  C12N9/42 ,  C12N9/48

CPC分类号： A61K35/747 ,  A61P31/04 ,  C12N9/18 ,  C12N9/2445 ,  C12N9/485 ,  C12Y301/01 ,  C12Y301/03002 ,  C12Y302/0102 ,  C12Y302/01021 ,  C12Y302/01031 ,  C12Y304/11001

摘要： The present invention relates to a Lactobacillus strain having antimicrobial activity against Gardnerella vaginalis and Candida albicans, a culture medium of the strain, and a cell-free supernatant of the strain, and to an antimicrobial composition containing the same, a pharmaceutical composition for preventing or treating Gardnerella vaginalis infection or Candida albicans infection containing the same, a pharmaceutical composition for prevention or treatment of vaginitis containing the same, a health functional food for prevention or ameliorating of vaginitis containing the same, and a quasi-drug composition for prevention or amelioration of vaginitis containing the same. The Lactobacillus paracasei MG4272 strain in accordance with the present disclosure has excellent antimicrobial activity against Gardnerella vaginalis and Candida albicans, and has excellent acid resistance, bile resistance, autoaggregation ability and epithelial cell adhesion ability and is suitable for probiotics and thus may be used in various ways for the prevention or treatment of Gardnerella vaginalis infection, Candida albicans infection and vaginitis.

公开(公告)号：US20190032037A1

公开(公告)日：2019-01-31

申请号：US15742892

申请日：2016-07-08

申请人： International Centre For Genetic Engineering & Biotechnology ,  Department of Biotechnology Ministry of Science & Technology

发明人： Syed Shams YAZDANI ,  Funso Emmanuel OGUMOLU

IPC分类号： C12N9/24 ,  C12N9/18 ,  C12N9/42 ,  C12N9/34

CPC分类号： C12N9/2402 ,  C12N9/18 ,  C12N9/2428 ,  C12N9/2437 ,  C12N9/2445 ,  C12N9/248 ,  C12N9/2482 ,  C12P2203/00 ,  C12Y301/01072 ,  C12Y302/01 ,  C12Y302/01003 ,  C12Y302/01004 ,  C12Y302/01008 ,  C12Y302/01021 ,  C12Y302/01055 ,  C12Y302/01091 ,  Y02E50/16

摘要： The present invention discloses a composition for biomass hydrolysis. The components of the composition may be obtained by biological or synthetic means. Synthetically, the components of the composition of the present invention may be obtained by amino acid synthesis or may be procured commercially.

公开(公告)号：US20180258449A1

公开(公告)日：2018-09-13

申请号：US15985042

申请日：2018-05-21

申请人： LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC ,  STELLENBOSCH UNIVERSITY

发明人： John McBride ,  Elena Brevnova ,  Mark Mellon ,  Allan Froehlich ,  Kristen Deleault ,  Vineet Rajgarhia ,  Riaan Den Haan ,  Merja Penttila ,  Marja Ilmen ,  Matti Siika-Aho ,  Jaana Uusitalo ,  Emily A. Stonehouse ,  Alan Gilbert ,  Haowen Xu ,  Deidre Willies ,  John Bardsley ,  Anu Koivula ,  Sanni Voutilainen

IPC分类号： C12P7/10 ,  C12N15/80 ,  C12P7/14 ,  C12P39/00 ,  C12N9/42

CPC分类号： C12P7/10 ,  C12N9/2437 ,  C12N9/2445 ,  C12N15/80 ,  C12P7/14 ,  C12P39/00 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16 ,  Y02E50/17

摘要： The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

公开(公告)号：US20180237759A1

公开(公告)日：2018-08-23

申请号：US15955162

申请日：2018-04-17

申请人： Novozymes, Inc.

发明人： Sandra Merino ,  Keith McFarland ,  Joel Cherry ,  Sarah Teter

IPC分类号： C12N9/42 ,  C12P7/10 ,  C12P19/14 ,  C07K14/37 ,  C12P19/16

CPC分类号： C12N9/2437 ,  C07K14/37 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/14 ,  C12P19/16 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16 ,  Y02E50/17

摘要： The present invention relates to cellulolytic compositions for degrading or converting cellulose-containing material and methods of producing and using the compositions.

公开(公告)号：US10053679B2

公开(公告)日：2018-08-21

申请号：US13638538

申请日：2010-03-31

申请人： Fumikazu Yokoyama

发明人： Fumikazu Yokoyama

IPC分类号： C12N9/24 ,  C12N9/42 ,  C12P19/02 ,  C12P19/14 ,  D06M16/00 ,  D21C5/00 ,  D21C5/02 ,  D21H21/10 ,  A23K20/189 ,  A23K10/14

CPC分类号： C12N9/2437 ,  A23K10/14 ,  A23K20/189 ,  C12N9/2445 ,  C12P19/02 ,  C12P19/14 ,  C12P2203/00 ,  C12Y302/01004 ,  C12Y302/01021 ,  D06M16/003 ,  D21C5/005 ,  D21C5/025 ,  D21H21/10 ,  Y02E50/16 ,  Y02W30/648

摘要： An object is to identify endoglucanase and β-glucosidase genes by isolating genomic DNA containing cellulase genes, which are classified into endoglucanases or β-glucosidases, from Acremonium cellulolyticus, and sequencing the nucleotide sequences thereof. The inventors intensively compared the amino acid sequences of known endoglucanases and β-glucosidases with each other to find conserved region of amino acid sequences in Acremonium cellulolyticus, and various primers were designed based on the information. PCR was carried out using the various primers thus designed and genomic DNA or cDNA as a template. As a result, gene fragments of endoglucanases and β-glucosidases were obtained. Primers were designed based on the gene fragments, and PCR was carried out to amplify nine genes of endoglucanases and β-glucosidases. The nucleotide sequences thereof were sequenced, and the present invention was completed.