公开(公告)号：US08598140B2

公开(公告)日：2013-12-03

申请号：US13634618

申请日：2011-04-12

申请人： Daniel J. Schneider ,  Akihiko Hisaminato ,  Sheela Waugh ,  Daniel Resnicow ,  Akira Nagabukuro ,  Toshihide Ono

发明人： Daniel J. Schneider ,  Akihiko Hisaminato ,  Sheela Waugh ,  Daniel Resnicow ,  Akira Nagabukuro ,  Toshihide Ono

IPC分类号： A61K48/00

CPC分类号： C07H19/10 ,  C07H19/06 ,  C07H21/04 ,  C12N15/115 ,  C12N2310/335

摘要： The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to β-NGF; pharmaceutical compositions comprising such β-NGF aptamers; and methods of making and using the same.

摘要翻译： 本公开一般涉及核酸领域，更具体地涉及能够结合β-NGF的适体; 包含这种β-NGF适体的药物组合物; 以及制作和使用它们的方法。

公开(公告)号：US20060288751A1

公开(公告)日：2006-12-28

申请号：US11475116

申请日：2006-06-27

申请人： Satoshi Tsuyuguchi ,  Toshihide Ono

发明人： Satoshi Tsuyuguchi ,  Toshihide Ono

IPC分类号： B21B17/06

CPC分类号： B21B21/00 ,  B21B21/02 ,  B21B25/00 ,  B21B38/04

摘要： In the cold rolling process by pilger rolling that holds a mandrel between each of paired roll-dies, by optimizing the side relief rate SR and the mandrel factors like the taper θ1 in the primary deformation zone of the mandrel and the taper θ2 in the final size reduction zone thereof, and the feed rate F of the workpiece material, and at the same time by properly adjusting the relationship between the side relief rate SR and the feed rate F, the dimension-related shape characteristics (near-perfect round shape) of the tube inside surface after the final finishing rolling process by pilger rolling can be ascertained to thereby ensure excellent surface property without requiring a new apparatus, and further without causing the decrease of the product yield and/or the increase of the manufacturing costs. Thus, this can be widely applied for producing steam generator tubes which exhibits high S/N ratio in the inner coil eddy current testing.

摘要翻译： 在通过在每个成对的辊模之间保持心轴的通过滚筒滚动的冷轧过程中，通过优化侧向释放速率SR和心轴因素，如心轴的主变形区域中的锥度θ1和锥形角2 其最终尺寸减小区域和工件材料的进给速度F，同时通过适当地调节侧面卸载速率SR和进给速度F之间的关系，尺寸相关的形状特征（接近完美的圆 形状）可以确定通过打孔滚轧进行最终精轧之后的管内表面，从而确保优异的表面性能而不需要新的装置，并且进一步不会导致产品产量的降低和/或制造成本的增加 。 因此，可以广泛地应用于内圈涡流检测中表现出高S / N比的蒸汽发生器管。

公开(公告)号：US08312751B2

公开(公告)日：2012-11-20

申请号：US13153567

申请日：2011-06-06

申请人： Hitoshi Suwabe ,  Toshihide Ono

发明人： Hitoshi Suwabe ,  Toshihide Ono

IPC分类号： B21B17/00 ,  B21B23/00

CPC分类号： C22C38/42 ,  B21B3/02 ,  B21B21/00 ,  B21C23/002 ,  B21C23/085 ,  C21D6/004 ,  C21D6/005 ,  C21D7/02 ,  C21D7/12 ,  C21D8/10 ,  C21D9/08 ,  C22C38/001 ,  C22C38/02 ,  C22C38/04 ,  C22C38/44

摘要： A method for producing a high alloy pipe having a minimum yield strength of 758.3 to 965.2 MPa, comprising: preparing a high alloy pipe having controlled amounts of C, Si, Mn, Ni, Cr, Mo, Cu, and N, the balance being Fe and impurities by a hot working or further by a solid-solution heat treatment; and then subsequently subjecting the high alloy pipe to a cold rolling. The cold rolling is performed such that the working ratio Rd, in terms of the reduction of area, in the final cold rolling step falls within a range of larger than 30% and equal to or less than 80%, and the following formula is satisfied: Rd(%)>(MYS−520)/3.1−(Cr+6×Mo+300×N) wherein Rd and MYS signify the working ratio (%) in terms of the reduction of area and the targeted yield strength (MPa), respectively, and Cr, Mo and N signify the mass % of the individual elements.

摘要翻译： 一种制造具有最低屈服强度为758.3〜965.2MPa的高合金管的方法，其特征在于，包括：制备具有受控量的C，Si，Mn，Ni，Cr，Mo，Cu和N的高合金管，余量为 Fe和杂质通过热加工或进一步通过固溶热处理; 然后对高合金管进行冷轧。 进行冷轧，使得最终冷轧工序中的面积减少率的工作比率Rd在大于30％且等于或小于80％的范围内，并且满足以下公式： ：Rd（％）>（MYS-520）/3.1-（Cr + 6×Mo + 300×N）其中Rd和MYS表示以面积的减少和目标屈服强度表示的加工率（％）（MPa ），Cr，Mo和N分别表示各元素的质量百分比。

公开(公告)号：US07197906B2

公开(公告)日：2007-04-03

申请号：US11475115

申请日：2006-06-27

申请人： Satoshi Tsuyuguchi ,  Toshihide Ono

发明人： Satoshi Tsuyuguchi ,  Toshihide Ono

IPC分类号： B21B17/04

CPC分类号： B21B21/00 ,  B21B21/005 ,  B21B21/02 ,  B21B38/00

摘要： In the cold rolling process by pilger rolling that holds a mandrel between each of paired roll-dies, by optimizing the side relief rate SR and the pass schedule factors such as the Area Rd, ID Rd and the feed rate F of the workpiece material, and further by properly selecting the taper θ1 in the primary deformation zone of mandrel and the taper θ2 in the final size reduction zone thereof, the dimension-related shape characteristics (near-perfect round shape) of the tube inside surface after the final finishing rolling process by pilger rolling can be ascertained to thereby ensure excellent surface property without requiring a new apparatus, and further without causing the decrease of the product yield and/or the increase of the manufacturing costs. Thus, this can be widely applied for producing steam generator tubes which exhibits high S/N ratio in the inner coil eddy current testing.

摘要翻译： 在通过在成对的辊模之间保持心轴的通过滚压轧制的冷轧过程中，通过优化侧面卸载速率SR和工件材料的面积Rd，ID Rd和进给速度F等通过时间表因素， 并且进一步通过适当地选择心轴的主变形区域中的锥形角度1和其最终尺寸减小区域中的锥形角度θ，最终的管内表面中的尺寸相关形状特征（近乎完美的圆形） 可以确定通过滚压轧制的精轧过程，从而确保优异的表面性能，而不需要新的装置，并且进一步不会导致产品产量的降低和/或制造成本的增加。 因此，可以广泛地应用于内圈涡流检测中表现出高S / N比的蒸汽发生器管。

公开(公告)号：US20060288750A1

公开(公告)日：2006-12-28

申请号：US11475115

申请日：2006-06-27

申请人： Satoshi Tsuyuguchi ,  Toshihide Ono

发明人： Satoshi Tsuyuguchi ,  Toshihide Ono

IPC分类号： B21B17/10

CPC分类号： B21B21/00 ,  B21B21/005 ,  B21B21/02 ,  B21B38/00

摘要： In the cold rolling process by pilger rolling that holds a mandrel between each of paired roll-dies, by optimizing the side relief rate SR and the pass schedule factors such as the Area Rd, ID Rd and the feed rate F of the workpiece material, and further by properly selecting the taper θ1 in the primary deformation zone of mandrel and the taper θ2 in the final size reduction zone thereof, the dimension-related shape characteristics (near-perfect round shape) of the tube inside surface after the final finishing rolling process by pilger rolling can be ascertained to thereby ensure excellent surface property without requiring a new apparatus, and further without causing the decrease of the product yield and/or the increase of the manufacturing costs. Thus, this can be widely applied for producing steam generator tubes which exhibits high S/N ratio in the inner coil eddy current testing.

摘要翻译： 在通过在成对的辊模之间保持心轴的通过滚压轧制的冷轧过程中，通过优化侧面卸载速率SR和工件材料的面积Rd，ID Rd和进给速度F等通过时间表因素， 并且进一步通过适当地选择心轴的主变形区域中的锥形角度1和其最终尺寸减小区域中的锥形角度θ，最终的管内表面中的尺寸相关形状特征（近乎完美的圆形） 可以确定通过滚压轧制的精轧过程，从而确保优异的表面性能，而不需要新的装置，并且进一步不会导致产品产量的降低和/或制造成本的增加。 因此，可以广泛地应用于内圈涡流检测中表现出高S / N比的蒸汽发生器管。