公开(公告)号：US20170304412A1

公开(公告)日：2017-10-26

申请号：US15636683

申请日：2017-06-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Eitan WONG ,  Ran AFIK

IPC: A61K38/48 ,  C12N9/64

CPC classification number: A61K38/4886 ,  C12N9/6489 ,  C12Y304/24086 ,  Y02A50/473

Abstract: A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R58, R56 and K57 which renders said polypeptide resistant to furin degradation said polypeptide being capable of downregulating an activity of TACE, thereby treating the inflammatory disease.

公开(公告)号：US20150158953A1

公开(公告)日：2015-06-11

申请号：US14624597

申请日：2015-02-18

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Irit SAGI ,  Gabriel Rosenblum

IPC: C07K16/40 ,  C12Q1/37 ,  G01N33/573

CPC classification number: C07K16/40 ,  A61K38/005 ,  A61K39/3955 ,  C07K2299/00 ,  C12N9/6491 ,  C12Q1/37 ,  C12Y304/24035 ,  G01N33/573 ,  G01N2333/96494 ,  G01N2500/04 ,  G01N2500/20

Abstract: A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.

Abstract translation: 公开了一种调节金属蛋白酶9（MMP-9）活性的方法。 该方法包括使MMP-9与与MMP-9的OG结构域特异性相互作用的试剂接触。 还可以公开能够与OG结构域特异性相互作用的分子，鉴定其的方法，包含其的药物组合物及其用途。

公开(公告)号：US20140370031A1

公开(公告)日：2014-12-18

申请号：US14474203

申请日：2014-09-01

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Tamar DANON

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/44

Abstract: A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.

Abstract translation: 一种生产金属蛋白抑制剂的方法，该方法包括产生针对包含金属离子结合的螯合剂的组合的抗体，其中选择具有与金属蛋白的功能结构域相似的结构和电子性质的组合物，从而产生金属蛋白抑制剂。

公开(公告)号：US20140141014A1

公开(公告)日：2014-05-22

申请号：US14168024

申请日：2014-01-30

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Netta Sela-Paswell ,  Tamar Danon ,  Raanan Margalit

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

Abstract: An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.

Abstract translation: 公开了包含抗原识别区的抗体，其包含选自SEQ ID NO：4-15的6个CDR氨基酸序列。 还公开了其用途。

公开(公告)号：US20130280247A1

公开(公告)日：2013-10-24

申请号：US13916633

申请日：2013-06-13

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Irit SAGI ,  Gabriel Rosenblum

IPC: A61K39/395 ,  A61K38/00

CPC classification number: C07K16/40 ,  A61K38/005 ,  A61K39/3955 ,  C07K2299/00 ,  C12N9/6491 ,  C12Q1/37 ,  C12Y304/24035 ,  G01N33/573 ,  G01N2333/96494 ,  G01N2500/04 ,  G01N2500/20

Abstract: A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.