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1.发明申请公开(公告)号：US20180134808A1
公开(公告)日：2018-05-17
申请号：US15865479
申请日：2018-01-09
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Irit SAGI , Tamar DANON , Netta SELA , Abraham SHANZER , Rina ARAD-YELLIN , Raghavendra KIKKERI
IPC: C07K16/44 , C07F3/06 , C07D233/61 , C07K16/40
CPC classification number: C07K16/44 , C07D233/61 , C07F3/06 , C07K16/40 , C07K2317/565 , C07K2317/76
Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.
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公开(公告)号：US20160257765A1
公开(公告)日：2016-09-08
申请号：US15161375
申请日：2016-05-23
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Irit SAGI , Tamar DANON , Netta SELA , Abraham SHANZER , Rina ARAD-YELLIN , Raghavendra KIKKERI
CPC classification number: C07K16/44 , C07D233/61 , C07F3/06 , C07K16/40 , C07K2317/565 , C07K2317/76
Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.
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3.发明申请ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS 审中-公开含有同样有用的抑制金属蛋白酶活性的抗体和药物组合物公开(公告)号：US20140370031A1
公开(公告)日：2014-12-18
申请号：US14474203
申请日：2014-09-01
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Irit SAGI , Tamar DANON
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K39/395 , A61K2039/505 , C07K16/44
Abstract: A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.
Abstract translation: 一种生产金属蛋白抑制剂的方法，该方法包括产生针对包含金属离子结合的螯合剂的组合的抗体，其中选择具有与金属蛋白的功能结构域相似的结构和电子性质的组合物，从而产生金属蛋白抑制剂。
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