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公开(公告)号：US08127926B2
公开(公告)日：2012-03-06
申请号：US12644160
申请日：2009-12-22
IPC分类号： A61L15/16
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00897
摘要： A patch package structure which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, a peripheral area of the first sheet material having been sealed to a peripheral area of the second sheet material to constitute the package, and a patch disposed in the package; in which the patch includes a backing, a pressure-sensitive adhesive layer formed on at least one side of the backing, and a release liner which protects the pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having a weakening line for assisting a removal of the release liner; and in which the second sheet material has specific first protrudent part, second protrudent part, third protrudent part and elevated part in a central area thereof except the peripheral area thereof.
摘要翻译： 一种贴片包装结构，包括：包括平面的第一片材和已经模制的第二片材的封装，第一片材的周边区域被密封到第二片材的周边区域，以构成第 包装和贴在包装中的贴片; 其中所述贴剂包括背衬，形成在所述背衬的至少一侧上的压敏粘合剂层和保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫，所述剥离衬垫具有弱化 用于帮助去除脱模衬垫的管线; 并且其中所述第二片材在其外围区域的中心区域中具有特定的第一突出部分，第二突出部分，第三突出部分和升高部分。
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公开(公告)号：US20090011159A1
公开(公告)日：2009-01-08
申请号：US12167085
申请日：2008-07-02
IPC分类号： B32B1/02
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00165 , A61F2013/00365 , Y10T428/13
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.
摘要翻译： 贴片包装结构技术领域本发明涉及一种贴片包装结构，其包括：包括第一片材和第二片材的封装，所述第一片材和第二片材在其周边部分被密封在一起; 以及布置在所述包装中的贴片，所述贴片包含背衬，层压在所述背衬的至少一侧上的压敏粘合剂层以及保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫， 所述剥离衬垫在其表面上具有在使用所述贴片时支撑所述剥离衬垫剥离的切割线，所述贴片设置在所述包装中，使得所述剥离衬垫面向所述第一片材的内表面， 所述第一片材具有第一区域，其中所述第一片材的内表面面向所述剥离衬垫的切割线，所述第一片材在所述第一区域中具有所述第一片材的内表面与所述第一片材的内表面之间的最小第一距离， 释放衬垫的表面，并且第一片材的内表面在第一区域中以最小第一距离与释放衬垫的表面间隔开。
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公开(公告)号：US08974816B2
公开(公告)日：2015-03-10
申请号：US12872447
申请日：2010-08-31
CPC分类号： A61F13/023 , A61F2013/00651 , A61F2013/0071 , A61K9/703 , A61K9/7038
摘要： The present invention provides a water resistant patch preparation having a central part and a peripheral part, which preparation is comprised of a support and an adhesive layer comprising a drug, which is formed on one surface of the support, wherein at least a part of a lateral end of the adhesive layer in the peripheral part is located inside a lateral end of the support, and the adhesive layer in the peripheral part has a thickness smaller than that of the adhesive layer in the central part.
摘要翻译： 本发明提供一种具有中心部分和周边部分的防水贴剂，该制剂由载体和包含药物的粘合剂层组成，其形成在载体的一个表面上，其中至少一部分 周边部分中的粘合剂层的侧端部位于支撑体的侧端内侧，周边部分中的粘合剂层的厚度小于中央部分的粘合剂层的厚度。
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公开(公告)号：US20130006203A1
公开(公告)日：2013-01-03
申请号：US13581166
申请日：2011-02-23
IPC分类号： A61M35/00
CPC分类号： A61K31/138 , A61F13/02 , A61F13/0253 , A61F13/0259 , A61F2013/00646 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing of bisoprolol or a salt thereof from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译： 本发明旨在提供一种粘合贴剂，其有效地抑制在储存期间粘合剂贴剂的粘合剂层的暴露区域渗出或粘附粘合剂层组分的发生以及比索洛尔或 其粘合剂层，从而防止药物含量的降低。 构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突起部 在其角落处的粘合剂贴剂。 此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。 此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。 在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。
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公开(公告)号：US09005174B2
公开(公告)日：2015-04-14
申请号：US13581079
申请日：2011-02-23
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
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公开(公告)号：US20120323191A1
公开(公告)日：2012-12-20
申请号：US13581079
申请日：2011-02-23
IPC分类号： A61M35/00
CPC分类号： A61K9/7061 , A61F2013/00651 , A61K9/7023 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译： 本发明旨在提供一种粘合贴片，其包含除比索洛尔以外的药物，并且其有效地抑制在保存期间从粘合剂贴剂的粘合剂层的暴露区域渗出或渗出粘合剂层组分的发生以及 从粘合剂层渗出药物的发生，从而防止药物含量的降低。 构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突起部 在其角落处的粘合剂贴剂。 此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。 此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。 在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。
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公开(公告)号：US20140158571A1
公开(公告)日：2014-06-12
申请号：US14232358
申请日：2012-07-13
申请人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
发明人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
IPC分类号： A61J1/00
CPC分类号： A61J1/00 , A61F13/00076 , A61F2013/00646 , A61F2013/00906
摘要： A packaging structure (100) for a patch includes a first and second base materials (120, 130) which have a peripheral edge part laminated with each other, and the patch is included therein. The first and second base materials (120, 130) have a first to forth sides (121 to 124, 131-134). At least one of the first and second base materials (120, 130) has a first to third opening parts (125 to 127, 135 to 137). The first to third opening parts (125 to 127, 135 to 137) guides so as to open toward the inner peripheral edge (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of the sealing part (120c, 130c).
摘要翻译： 用于贴片的包装结构（100）包括具有彼此层压的周缘部分的第一和第二基底材料（120,130），并且其中包括贴片。 第一和第二基材（120,130）具有第一至第四侧（121至124,131-134）。 第一和第二基底材料（120,130）中的至少一个具有第一至第三开口部分（125至127,135至137）。 第一至第三开口部（125〜127,135〜137）引导朝向密封部（120c，130c）的内周缘（120c1,120c2,120c4,130c1,130c2,130c4）开口。
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公开(公告)号：US20110243998A1
公开(公告)日：2011-10-06
申请号：US13074911
申请日：2011-03-29
申请人： Sachiko SAKAMOTO , Akinori Hanatani , Arimichi Okazaki , Hitoshi Akemi , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Sachiko SAKAMOTO , Akinori Hanatani , Arimichi Okazaki , Hitoshi Akemi , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61K9/00 , A61K31/445 , A61K31/4174 , A61K31/34 , A61K31/192 , A61K31/195 , A61K31/4152 , A61K31/46
CPC分类号： A61K9/7061 , A61K9/7053
摘要： The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the adhesive layer immediately after application of a physical stimulation to the adhesive layer, while a crystal of the drug is formed during preservation after the physical stimulation. The patch preparation which does not require an increase in the area and thickness of an adhesive layer, achieves a sufficiently high skin permeation amount of the drug, shows good adhesiveness to skin, and permits a long-term adhesion to skin. The invention also provides a method of producing the patch preparation.
摘要翻译： 本发明提供了一种补片制剂，其包含（a）支持物和（b）在载体表面上含有药物的粘合剂层，其中在施加物理刺激之后立即在粘合剂层中形成药物的晶体 而在物理刺激后的保存期间形成药物的晶体。 不需要增加粘合剂层的面积和厚度的贴片制剂能够获得足够高的皮肤渗透量的药物，对皮肤具有良好的粘附性，并且可以长期粘附到皮肤上。 本发明还提供一种制备贴剂的方法。
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公开(公告)号：US09326952B2
公开(公告)日：2016-05-03
申请号：US13581079
申请日：2011-02-23
CPC分类号： A61K9/7061 , A61F2013/00651 , A61K9/7023 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译： 本发明旨在提供一种粘合贴片，其包含除比索洛尔以外的药物，并且其有效地抑制在保存期间从粘合剂贴剂的粘合剂层的暴露区域渗出或渗出粘合剂层组分的发生以及 从粘合剂层渗出药物的发生，从而防止药物含量的降低。 构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突出部 在其角落处的粘合剂贴剂。 此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。 此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。 在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。
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公开(公告)号：US08394404B2
公开(公告)日：2013-03-12
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译： 本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许 当在期望的特定时间段之后要从皮肤表面剥离时，易于剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体地说，本发明提供了一种粘合剂材料，其包含层叠在载体的一个表面上的载体和粘合剂层，其中所述粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 4 Pa·s，并且包含 两种具有不同流动性的合成橡胶。
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