公开(公告)号：US20140009758A1

公开(公告)日：2014-01-09

申请号：US14006436

申请日：2011-03-24

Applicant: Zhiyong Li ,  Ivan Naumov ,  Farzad Parvaresh

Inventor： Zhiyong Li ,  Ivan Naumov ,  Farzad Parvaresh

IPC: G01N21/65 ,  B05D3/00

CPC classification number: G01N21/65 ,  B05D3/007 ,  G01N21/658

Abstract: An apparatus for use in sensing applications includes a substrate and a plurality of clusters arranged in an aperiodic configuration on the substrate, wherein each of the plurality of clusters is formed of a plurality of Raman-active material nano-particles, and wherein each of the Raman-active material nano-particles is positioned in a substantially ordered configuration with respect to each other in each of the respective plurality of clusters.

Abstract translation: 用于感测应用的装置包括基板和在基板上以非周期配置布置的多个簇，其中多个簇中的每一个由多个拉曼活性材料纳米颗粒形成，并且其中 拉曼活性材料纳米颗粒在相应的多个簇中的每一个中相对于彼此定位成基本排列的构型。

公开(公告)号：US20130278928A1

公开(公告)日：2013-10-24

申请号：US13449612

申请日：2012-04-18

Applicant: Devin Alexander Mourey ,  James William Stasiak ,  Zhiyong Li

Inventor： Devin Alexander Mourey ,  James William Stasiak ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/274 ,  G01N21/278 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy calibration curve generating system includes a SERS sensor, which includes a substrate and a plurality of sensing members formed on the substrate. Each of the sensing members includes a plurality of SERS signal amplifying structures. An inkjet dispensing device is to dispense different concentrations of a solution including a known analyte of interest onto the respective sensing members to form a concentration dependent array. A Raman spectrometer is to interrogate the concentration dependent array. A processor is operatively connected to each of the inkjet dispensing device and the Raman spectrometer. Computer-readable instructions are embedded on a non-transitory, tangible computer-readable medium and are executable by the processor. The computer-readable instructions are to automatically generate an intensity profile as a function of concentration for the concentration dependent array.

Abstract translation: 表面增强拉曼光谱校准曲线生成系统包括SERS传感器，其包括衬底和形成在衬底上的多个感测构件。 每个感测构件包括多个SERS信号放大结构。 喷墨分配装置是将不同浓度的包括已知分析物的溶液分配到相应的感测构件上以形成浓度依赖阵列。 拉曼光谱仪是询问浓度依赖阵列。 处理器可操作地连接到每个喷墨分配装置和拉曼光谱仪。 计算机可读指令嵌入在非暂时有形的计算机可读介质中，并且可由处理器执行。 计算机可读指令是自动生成作为浓度依赖阵列的浓度的函数的强度分布。

公开(公告)号：US08549027B2

公开(公告)日：2013-10-01

申请号：US12487134

申请日：2009-06-18

Applicant: Zhiyong Li ,  Rajesh Hotchandani ,  Austin Patrick Maher

Inventor： Zhiyong Li ,  Rajesh Hotchandani ,  Austin Patrick Maher

IPC: G06F7/00

CPC classification number: G06F3/0481

Abstract: Computer-implemented systems and methods are provided for reducing a number of options presented to a user where the options have characteristics that are arranged in a multi-dimensional hierarchical space. A system and method can be configured to identify common dimensions using dimension nodes in dimensional points and identify compatible nodes for each dimension in the multi-dimensional hierarchical space by determining whether an association exists. Compatible pairs of surviving points are generated after applying each of the compatible nodes from the common dimensions. Greatest lower bounds (GLBs) are computed for each of the generated compatible points, and a set of options is generated comprising points from the generated compatible points and the computed GLBs.

Abstract translation: 提供了计算机实现的系统和方法，用于减少呈现给用户的多个选项，其中选项具有排列在多维分层空间中的特征。 可以将系统和方法配置为使用维度点中的维度节点来识别公共维度，并通过确定关联是否存在来识别多维分层空间中的每个维度的兼容节点。 在从普通维度应用每个兼容节点之后生成兼容的幸存点对。 为每个生成的兼容点计算最大下限（GLB），并且生成包括来自所生成的兼容点和计算出的GLB的点的一组选项。

公开(公告)号：US08542355B2

公开(公告)日：2013-09-24

申请号：US13383078

申请日：2009-07-08

Applicant: David A. Fattal ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan Wang

Inventor： David A. Fattal ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan Wang

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y20/00

Abstract: A light amplifying device for surface enhanced Raman spectroscopy is disclosed herein. The device includes a dielectric layer having two opposed surfaces. A refractive index of the dielectric layer is higher than a refractive index of a material or environment directly adjacent thereto. At least one opening is formed in one of the two opposed surfaces of the dielectric layer, and at least one nano-antenna is established on the one of the two opposed surfaces of the dielectric layer. A gain region is positioned in the dielectric layer or adjacent to another of the two opposed surfaces of the dielectric layer.

Abstract translation: 本文公开了一种用于表面增强拉曼光谱的光放大装置。 该装置包括具有两个相对表面的电介质层。 电介质层的折射率高于与其直接相邻的材料或环境的折射率。 至少一个开口形成在电介质层的两个相对表面之一中，并且至少一个纳米天线被建立在电介质层的两个相对表面之一上。 增益区域位于电介质层中或邻近电介质层的两个相对表面中的另一个。

公开(公告)号：US08472018B2

公开(公告)日：2013-06-25

申请号：US12847982

申请日：2010-07-30

Applicant: Michael J. Stuke ,  Michael R. T. Tan ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Wei Wu

Inventor： Michael J. Stuke ,  Michael R. T. Tan ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01N21/658

Abstract: Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.

Abstract translation: 系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。 此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

公开(公告)号：US20130120748A1

公开(公告)日：2013-05-16

申请号：US13810982

申请日：2010-07-30

Applicant: Zhiyong Li ,  Min Hu ,  Wei Wu

Inventor： Zhiyong Li ,  Min Hu ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: A surface enhanced Raman spectroscopy (SERS) probe apparatus and a method of SERS probing employ Raman-active surfaces of a plurality of nanoscale field concentrator (NFC) structures at a terminal end of an optical fiber. The SERS probe apparatus includes an optical fiber having an optical path and a terminal end that terminates the optical path. The SERS probe apparatus further includes a plurality of NFC structures and nanoparticles on surfaces of the plurality of NFC structures. First ends of the NFC structures are adjacent to the terminal end of optical fiber. The nanoparticles are Raman active to an analyte.

Abstract translation: 表面增强拉曼光谱（SERS）探针装置和SERS探测的方法在光纤的末端使用多个纳米尺度场集中器（NFC）结构的拉曼活性表面。 SERS探针装置包括具有光路的光纤和终止光路的终端。 SERS探针装置还包括在多个NFC结构的表面上的多个NFC结构和纳米颗粒。 NFC结构的第一端与光纤的终端相邻。 纳米颗粒是对分析物有活性的拉曼。

公开(公告)号：US08416406B2

公开(公告)日：2013-04-09

申请号：US12914655

申请日：2010-10-28

Applicant: Michael Josef Stuke ,  Shih-Yuan Wang ,  Zhiyong Li

Inventor： Michael Josef Stuke ,  Shih-Yuan Wang ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: B82Y15/00 ,  G01N21/65 ,  G01N21/658

Abstract: A sensing device that produces a Raman signal includes micro-rods or nano-rods arranged on a substrate in a two-dimensional (2D) array, each of the rods having a length in a single row being substantially the same, with the rod length of each row being different from the rod length of each other row. Each row of rods has a respective resonant vibration frequency that varies from row to row. A source of vibration energy, operatively connected to the substrate, excites vibration in each of the rods such that a responding row resonates when an exciting frequency approaches the resonant vibration frequency of the responding row. A method includes exposing the 2D array to a light source and analyzing Raman scattering at each rod of the 2D array to render a Raman map.

Abstract translation: 产生拉曼信号的感测装置包括以二维（2D）阵列布置在基底上的微棒或纳米棒，每根棒具有基本上相同的长度，其中棒长度 每行的距离与每隔一行的杆长度不同。 每排棒具有相应的谐振振动频率，其逐行变化。 可操作地连接到基板的振动能量源激发每个杆中的振动，使得当激励频率接近响应行的谐振振动频率时，响应行谐振。 一种方法包括将2D阵列暴露于光源并分析2D阵列的每个杆处的拉曼散射以呈现拉曼图。

公开(公告)号：US08358407B2

公开(公告)日：2013-01-22

申请号：US12771753

申请日：2010-04-30

Applicant: Min Hu ,  Wei Wu ,  Fung Suong Ou ,  Zhiyong Li ,  R. Stanley Williams

Inventor： Min Hu ,  Wei Wu ,  Fung Suong Ou ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/40

CPC classification number: G01N21/658 ,  B82Y15/00

Abstract: An integrated device for enhancing signals in Surface Enhanced Raman Spectroscopy (SERS). The integrated device comprising an array of nanostructures comprising a material, wherein the material is configured to allow light to pass through. The integrated device also comprising SERS active nanoparticles disposed on at least portion of the array of nanostructures and a mirror integrated below a base of the array of nanostructures. The mirror is configured to reflect light passing through the material into the array of nanostructures.

Abstract translation: 一种用于增强表面增强拉曼光谱（SERS）信号的集成器件。 所述集成器件包括纳米结构的阵列，其包括材料，其中所述材料被配置为允许光通过。 该集成装置还包括设置在纳米结构阵列的至少一部分上的SERS活性纳米颗粒和集成在纳米结构阵列的基底下方的反射镜。 镜子被配置为将通过材料的光反射到纳米结构阵列中。

公开(公告)号：US08330951B2

公开(公告)日：2012-12-11

申请号：US11413516

申请日：2006-04-28

Applicant: Zhiyong Li ,  William M. Tong ,  R. Stanley Williams

Inventor： Zhiyong Li ,  William M. Tong ,  R. Stanley Williams

IPC: G01J3/44 ,  G01N33/00 ,  G01N21/62 ,  H01J9/12

CPC classification number: G01N21/658 ,  Y10T428/218 ,  Y10T428/28

Abstract: Packaged NERS-active structures are disclosed that include a NERS substrate having a NERS-active structure thereon, and a packaging substrate over the NERS substrate having an opening therethrough, the opening in alignment with the NERS-active structure. A membrane may cover the opening in the packaging substrate. In order to perform nanoenhanced Raman spectroscopy, the membrane may be removed, and an analyte placed on the NERS substrate adjacent the NERS-active structure. The membrane may be replaced with another membrane after the analyte has been placed on the substrate. The membrane may maintain the pristine state of the substrate before it is deployed, and the replacement membrane may preserve the substrate and analyte for archival purposes. Also disclosed are methods for performing NERS with packaged NERS-active structures.

Abstract translation: 公开了封装的NERS-活性结构，其包括其上具有NERS-活性结构的NERS衬底和在NERS衬底上的具有穿过其中的开口的封装衬底，该开口与NERS-活性结构对准。 膜可以覆盖封装衬底中的开口。 为了进行纳米增强拉曼光谱，可以去除膜，并将分析物放置在邻近NERS-活性结构的NERS衬底上。 在将分析物放置在基底上之后，膜可以用另一膜替代。 膜可以在其被部署之前保持基材的原始状态，并且替换膜可以保留底物和分析物用于归档目的。 还公开了使用封装的NERS-活性结构来执行NERS的方法。

公开(公告)号：US08319963B2

公开(公告)日：2012-11-27

申请号：US12772063

申请日：2010-04-30

Applicant: Min Hu ,  Wei Wu ,  Fung Suong Ou ,  Zhen Peng ,  Zhiyong Li ,  R. Stanley Williams

Inventor： Min Hu ,  Wei Wu ,  Fung Suong Ou ,  Zhen Peng ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658 ,  G01N21/7746

Abstract: A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies.

Abstract translation: 一种紧凑的传感器系统，包括：配置用于光子 - 物质相互作用的分析单元，其中从光源接收光子; 所述集成光谱分析仪包括：与所述分析单元耦合的波导，所述波导被配置为通过所述波导传播一组频率;以及波导，其被配置为用于识别一组频率。 一个或多个与所述波导耦合的环形谐振器，所述一个或多个环形谐振器包括预定带宽并被配置用于捕获与所述预定带宽内的频率相对应的频率集合; 以及与所述一个或多个可调环形谐振器耦合的一个或多个频率检测器，所述一个或多个频率检测器被配置用于产生标识所述一组频率中的每一个的电信号。