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公开(公告)号：US08848183B2
公开(公告)日：2014-09-30
申请号：US13188941
申请日：2011-07-22
申请人： Wei Yi , Fung Suong Ou , Min Hu , Wei Wu , Zhiyong Li
发明人： Wei Yi , Fung Suong Ou , Min Hu , Wei Wu , Zhiyong Li
CPC分类号： G01N21/658 , B82Y15/00 , B82Y20/00 , B82Y40/00 , Y10T29/49826 , Y10T428/24893
摘要： An apparatus includes a substrate and a plurality of nano-fingers attached at respective first ends to the substrate and freely movable along their lengths, in which a first set of the plurality of nano-fingers comprises a first physical characteristic, wherein a second set of the plurality of nano-fingers comprises a second physical characteristic, and wherein the first physical characteristic differs from the second physical characteristic.
摘要翻译： 一种装置包括：衬底和多个纳米指，其各自的第一端附接到衬底并且可沿其长度自由移动，其中多个纳米指的第一组包括第一物理特性，其中第二组 所述多个纳米指包含第二物理特性，并且其中所述第一物理特性与所述第二物理特性不同。
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公开(公告)号：US08603606B2
公开(公告)日：2013-12-10
申请号：US12916239
申请日：2010-10-29
申请人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
发明人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
CPC分类号： G01N21/658 , B81B3/0005 , Y10T428/24355 , Y10T428/24612
摘要： A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.
摘要翻译： 用于表面增强拉曼散射（SERS）的器件。 该装置包括从衬底表面突出的多个纳米结构，设置在所述多个纳米结构的一部分上的SERS活性金属，以及设置在多个纳米结构和SERS活性金属上的低摩擦膜。 低摩擦膜是为了防止多个纳米结构之间的粘附。
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公开(公告)号：US20130021605A1
公开(公告)日：2013-01-24
申请号：US13188941
申请日：2011-07-22
申请人： Wei Yi , Fung Suong Ou , Min Hu , Wei Wu , Zhiyong Li
发明人： Wei Yi , Fung Suong Ou , Min Hu , Wei Wu , Zhiyong Li
CPC分类号： G01N21/658 , B82Y15/00 , B82Y20/00 , B82Y40/00 , Y10T29/49826 , Y10T428/24893
摘要： An apparatus includes a substrate and a plurality of nano-fingers attached at respective first ends to the substrate and freely movable along their lengths, in which a first set of the plurality of nano-fingers comprises a first physical characteristic, wherein a second set of the plurality of nano-fingers comprises a second physical characteristic, and wherein the first physical characteristic differs from the second physical characteristic.
摘要翻译： 一种装置包括：衬底和多个纳米指，其各自的第一端附接到衬底并且可沿其长度自由移动，其中多个纳米指的第一组包括第一物理特性，其中第二组 所述多个纳米指包含第二物理特性，并且其中所述第一物理特性与所述第二物理特性不同。
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公开(公告)号：US08279437B2
公开(公告)日：2012-10-02
申请号：US12836097
申请日：2010-07-14
申请人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/18 , G01J3/44 , G01N21/65 , G01N2021/651
摘要： An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.
摘要翻译： 用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。 该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。 该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。
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公开(公告)号：US08269963B2
公开(公告)日：2012-09-18
申请号：US12771779
申请日：2010-04-30
申请人： Fung Suong Ou , Min Hu , Wei Wu , Zhiyong Li , R Stanley Williams
发明人： Fung Suong Ou , Min Hu , Wei Wu , Zhiyong Li , R Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable layer and a plurality of SERS-active nanoparticles disposed at one or more locations on the deformable layer, wherein the one or more locations are configured to be illuminated with light of a pump wavelength to cause Raman excitation light to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles. In addition, a morphology of the deformable layer is configured to be controllably varied to modify an intensity of the Raman scattered light produced from the molecules.
摘要翻译： 用于进行表面增强拉曼光谱（SERS）的可调谐装置包括可变形层和设置在可变形层上的一个或多个位置处的多个SERS活性纳米颗粒，其中所述一个或多个位置被配置为用 泵浦波长以使拉曼激发光与纳米颗粒相互作用，并从靠近纳米颗粒的分子产生增强的拉曼散射光。 此外，可变形层的形态被配置为可控地改变以改变由分子产生的拉曼散射光的强度。
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公开(公告)号：US20110267610A1
公开(公告)日：2011-11-03
申请号：US12772063
申请日：2010-04-30
申请人： Min HU , Wei Wu , Fung Suong Ou , Zhen Peng , Zhiyong Li , R. Stanley Williams
发明人： Min HU , Wei Wu , Fung Suong Ou , Zhen Peng , Zhiyong Li , R. Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01N21/7746
摘要： A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies.
摘要翻译： 一种紧凑的传感器系统，包括：配置用于光子 - 物质相互作用的分析单元，其中从光源接收光子; 所述集成光谱分析仪包括：与所述分析单元耦合的波导，所述波导被配置为通过所述波导传播一组频率;以及波导，其被配置为用于识别一组频率。 一个或多个与所述波导耦合的环形谐振器，所述一个或多个环形谐振器包括预定带宽并被配置用于捕获与所述预定带宽内的频率相对应的频率集合; 以及与所述一个或多个可调环形谐振器耦合的一个或多个频率检测器，所述一个或多个频率检测器被配置用于产生标识所述一组频率中的每一个的电信号。
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公开(公告)号：US20110188035A1
公开(公告)日：2011-08-04
申请号：US12697156
申请日：2010-01-29
申请人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
发明人： Huei Pei Kuo , Michael J. Stuke , Min Hu , Fung Suong Ou , Shih-Yuan (SY) Wang , Alexandre M. Bratkovski , Wei Wu , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.
摘要翻译： 振动尖端表面增强拉曼光谱（SERS）装置，系统和方法采用配置为振动的纳米针。 该装置包括在与连接到基底的端相对的自由端处具有基本尖锐的尖端的纳米针。 尖端构造成吸附分析物。 该装置还包括一个被配置为提供交流（AC）电场的振动源，其引起自由端和纳米针的尖端的振动。 在AC电场的影响下，纳米针的振动有助于检测吸附在纳米针尖上的分析物的拉曼散射信号。 该系统还包括配置为与纳米针的振动协同地选通的同步检测器。 该方法包括引起振动，照亮振动尖端以产生拉曼信号，并使用检测器检测拉曼信号。
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公开(公告)号：US09709538B2
公开(公告)日：2017-07-18
申请号：US14239330
申请日：2011-09-30
申请人： Wei Wu , Zhiyong Li , Ansoon Kim , Min Hu , Michael Josef Stuke
发明人： Wei Wu , Zhiyong Li , Ansoon Kim , Min Hu , Michael Josef Stuke
CPC分类号： G01N31/22 , B01L3/5085 , B01L3/50853 , B01L2200/141 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B82Y15/00 , G01N21/648 , G01N21/658 , G01N2201/0227 , G01N2201/023 , Y10T436/25
摘要： Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure.
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公开(公告)号：US09678013B2
公开(公告)日：2017-06-13
申请号：US14394295
申请日：2012-04-20
申请人： Alexandre M. Bratkovski , Zhiyong Li , Wei Wu , Min Hu , R. Stanley Williams , Ansoon Kim
发明人： Alexandre M. Bratkovski , Zhiyong Li , Wei Wu , Min Hu , R. Stanley Williams , Ansoon Kim
CPC分类号： G01N21/658 , B01L3/5088 , B01L2300/0627 , B01L2300/0819 , B01L2300/161 , G01N21/648 , G01N35/00009 , G01N2035/00019
摘要： Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.
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公开(公告)号：US09001324B2
公开(公告)日：2015-04-07
申请号：US13810982
申请日：2010-07-30
申请人： Zhiyong Li , Min Hu , Wei Wu
发明人： Zhiyong Li , Min Hu , Wei Wu
CPC分类号： G01N21/658
摘要： A surface enhanced Raman spectroscopy (SERS) probe apparatus and a method of SERS probing employ Raman-active surfaces of a plurality of nanoscale field concentrator (NFC) structures at a terminal end of an optical fiber. The SERS probe apparatus includes an optical fiber having an optical path and a terminal end that terminates the optical path. The SERS probe apparatus further includes a plurality of NFC structures and nanoparticles on surfaces of the plurality of NFC structures. First ends of the NFC structures are adjacent to the terminal end of optical fiber. The nanoparticles are Raman active to an analyte.
摘要翻译： 表面增强拉曼光谱（SERS）探针装置和SERS探测的方法在光纤的末端使用多个纳米尺度场集中器（NFC）结构的拉曼活性表面。 SERS探针装置包括具有光路的光纤和终止光路的终端。 SERS探针装置还包括在多个NFC结构的表面上的多个NFC结构和纳米颗粒。 NFC结构的第一端与光纤的终端相邻。 纳米颗粒是对分析物有活性的拉曼。
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