公开(公告)号：US20120115177A1

公开(公告)日：2012-05-10

申请号：US13146689

申请日：2009-08-05

申请人： John Rodenrys

发明人： John Rodenrys

IPC分类号： G01N21/75 ,  C12Q1/34 ,  C12Q1/02 ,  C12Q1/37

CPC分类号： C12Q1/37 ,  C12Q1/44 ,  G01N2333/918 ,  G01N2333/96438 ,  G01N2333/96494 ,  G01N2800/32 ,  Y10T436/142222 ,  Y10T436/147777 ,  Y10T436/173845 ,  Y10T436/18 ,  Y10T436/182 ,  Y10T436/200833 ,  Y10T436/201666

摘要： Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock.

摘要翻译： 提出了用于诊断和分期休克，特别是非败血性休克的方法和试剂盒，其中从生物样品测量蛋白酶活性和/或挥发性化合物以鉴定和/或进行休克。

公开(公告)号：US20070286854A1

公开(公告)日：2007-12-13

申请号：US11578798

申请日：2005-04-15

申请人： Stefan Golz ,  Bruggemeiere Ulf ,  Andeas Geerts

发明人： Stefan Golz ,  Bruggemeiere Ulf ,  Andeas Geerts

IPC分类号： G01N33/53 ,  A61K38/17 ,  A61P1/00 ,  A61P11/00 ,  A61P13/00 ,  A61P17/00 ,  A61P19/00 ,  G01N33/567 ,  A61P25/00 ,  A61P3/00 ,  A61P35/00 ,  A61P7/00 ,  A61P9/00 ,  C12Q1/68

CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/96438 ,  G01N2500/04

摘要： The invention provides a human DPP1 which is associated with the infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与感染，心血管疾病，呼吸系统疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类DPP1。 本发明还提供了用于鉴定可用于治疗或预防感染，心血管疾病，呼吸系统疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病的化合物的测定 。 本发明还涉及结合和/或活化或抑制DPP1的活性的化合物以及包含这些化合物的药物组合物。