公开(公告)号：US3445529A

公开(公告)日：1969-05-20

申请号：US3445529D

申请日：1967-06-09

Applicant: TEXACO INC

Inventor： SMETANA RICHARD D

IPC: C07C201/02 ,  C07C201/08 ,  C07C203/04 ,  C07C203/08 ,  C07C205/02 ,  C07C205/05 ,  C07C79/02 ,  C07C77/00 ,  C07C77/02

CPC classification number: C07C201/02 ,  C07C201/08 ,  C07C205/02 ,  C07C203/04

公开(公告)号：US2977384A

公开(公告)日：1961-03-28

申请号：US43727854

申请日：1954-06-16

Applicant: ICI LTD

Inventor： ROY BENTLEY ,  NISBET THRUSTON MERVYN

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：US2768964A

公开(公告)日：1956-10-30

申请号：US35787953

申请日：1953-05-27

Applicant: DU PONT

Inventor： SPAETH CHARLES P

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：US2396330A

公开(公告)日：1946-03-12

申请号：US58008045

申请日：1945-02-27

Applicant: DU PONT

Inventor： EDWARD LUFKIN JAMES

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/08 ,  C07C203/04

公开(公告)号：US2363834A

公开(公告)日：1944-11-28

申请号：US44913042

申请日：1942-06-30

Applicant: HERCULES POWDER CO LTD

Inventor： CRATER WILLARD DE C

IPC: C07B43/02 ,  C07C201/02 ,  C07C203/04

CPC classification number: C07B43/02 ,  C07C201/02 ,  C07C203/04

公开(公告)号：US2294592A

公开(公告)日：1942-09-01

申请号：US33226640

申请日：1940-04-29

Applicant: TROJAN POWDER CO

Inventor： WYLER JOSEPH A

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：US2254352A

公开(公告)日：1941-09-02

申请号：US17869037

申请日：1937-12-08

Applicant: STANDARD OIL DEV CO

Inventor： CLOUD GOULD H ,  SPARKS WILLIAM J

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：US2165435A

公开(公告)日：1939-07-11

申请号：US16803837

申请日：1937-10-08

Applicant: TROJAN POWDER CO

Inventor： WYLER JOSEPH A

IPC: C07C201/02

CPC classification number: C07H11/02

公开(公告)号：US10988438B2

公开(公告)日：2021-04-27

申请号：US16967057

申请日：2019-02-12

Applicant: NICOX S.A.

Inventor： Nicoletta Almirante

IPC: C07C231/12 ,  C07C405/00 ,  C07C291/02 ,  C07C201/02

Abstract: The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group.
The 6-(nitrooxy)hexanoyl chloride intermediate is prepared by ring-opening reaction of 2-caprolactone and subsequent nitration of the 6-hydroxyhexanoic acid potassium salt with a mixture of HNO3 and H2SO4 in dichloromethane.

公开(公告)号：US07335789B2

公开(公告)日：2008-02-26

申请号：US10534868

申请日：2003-11-06

Applicant: Nevio Francescutti ,  Tiziano Scubla ,  Fausto Gorassini ,  Graziano Castaldi

Inventor： Nevio Francescutti ,  Tiziano Scubla ,  Fausto Gorassini ,  Graziano Castaldi

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C01B21/46 ,  C07C201/02 ,  C07C203/04

Abstract: A process for the preparation of compounds of formula (I): HO-A-ONO2  (I) wherein A is a C2-C6 alkylene chain, the compounds of formula (I) being synthesized by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.

Abstract translation: 制备式（I）化合物的方法：<？in-line-formula description =“In-line formula”end =“lead”？HO-A-ONO 2（I ）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中A是C 2 -C 6亚烷基链， 本文公开了通过用“稳定”的硝酸硝化相应的链烷二醇合成的式（I）化合物。 该过程对操作员更安全，并允许在工业规模上获得有利的产量。