公开(公告)号：US11939388B2

公开(公告)日：2024-03-26

申请号：US17360437

申请日：2021-06-28

Applicant: GENMAB A/S ,  BioNTech SE

Inventor： Isil Altintas ,  David Satijn ,  Rik Rademaker ,  Paul Parren ,  Friederike Gieseke ,  Ugur Sahin

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/569

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  G01N33/56972 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/92

Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.

公开(公告)号：US11866514B2

公开(公告)日：2024-01-09

申请号：US16777053

申请日：2020-01-30

Applicant: GENMAB A/S

Inventor： Aran Frank Labrijn ,  Joyce I. Meesters ,  Ewald T. J. Van Den Bremer ,  Joost J. Neijssen ,  Patrick Van Berkel ,  Bart De Goeij ,  Tom Vink ,  Jan Van De Winkel ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/46 ,  C07K16/10 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/468 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/40 ,  G01N33/6854 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.

公开(公告)号：US11858995B2

公开(公告)日：2024-01-02

申请号：US17559935

申请日：2021-12-22

Applicant: GENMAB A/S

Inventor： Brian Elliott ,  Jenny Jianlin Chen ,  Tahamtan Ahmadi ,  Christopher W. L. Chiu ,  Esther C. W. Breij ,  Ida Hiemstra ,  Maria N. Jure-Kunkel

IPC: A61K39/00 ,  C07K16/28

CPC classification number: C07K16/2809 ,  C07K16/2887 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/31

Abstract: Provided are methods of clinical treatment of chronic lymphoblastic leukemia (CLL) in human subjects using a bispecific antibody which binds to CD3 and CD20.

公开(公告)号：US20230312759A1

公开(公告)日：2023-10-05

申请号：US18025208

申请日：2021-09-10

Applicant: GENMAB A/S

Inventor： Brian ELLIOTT ,  Tahamtan AHMADI ,  Patricia GARRIDO CASTRO

IPC: C07K16/46 ,  A61P35/00

CPC classification number: C07K16/468 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/31

Abstract: Provided are methods of clinical treatment of diffuse large B-cell lymphoma (DLBCL) (e.g., relapsed and/or refractory DLBCL ineligible for autologous stem cell transplant) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of car regimen of gemcitabine and oxaliplatin (GemOx).

公开(公告)号：US20230312757A1

公开(公告)日：2023-10-05

申请号：US18025202

申请日：2021-09-10

Applicant: GENMAB A/S

Inventor： Brian ELLIOTT ,  Jenny J. CHEN ,  Tahamtan AHMADI ,  Christopher W.L. CHIU ,  Esther C.W. BRElJ ,  Ida HIEMSTRA ,  Maria N. JURE-KUNKEL

IPC: C07K16/46 ,  A61P35/00

CPC classification number: C07K16/468 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/31

Abstract: Provided are methods of clinical treatment of chromic lymphoblastic leukemia (CLL) inhuman subjects using a bispecific-antibody which binds to CD3 and CD20.

公开(公告)号：US20230295335A1

公开(公告)日：2023-09-21

申请号：US18184120

申请日：2023-03-15

Applicant: Genmab A/S ,  BioNTech SE

Inventor： Andreea IOAN ,  Esther Cornelia Wilhelmina BREIJ ,  Lars GUELEN ,  David P.E. SATIJN ,  Ugur SAHIN ,  Alexander MUIK ,  Kristina SCHÖDEL ,  Sina FELLERMEIER-KOPF ,  Bart-Jan DE KREUK ,  Richard HIBBERT ,  Janine SCHUURMAN ,  Aran Frank LABRIJN

IPC: C07K16/30 ,  C07K16/28

CPC classification number: C07K16/30 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/92

Abstract: The present invention provides a binding agent that binds to EpCAM and to CD137 which is useful to treat or prevent a tumor or cancer, or to prevent progression of a tumor or cancer.

公开(公告)号：US20230272105A1

公开(公告)日：2023-08-31

申请号：US17792268

申请日：2021-01-15

Applicant: GENMAB A/S

Inventor： Jacob D. CLAUSEN ,  Richard HIBBERT ,  Michael B. DALGAARD

IPC: C07K16/28 ,  A61K47/22 ,  A61K47/12 ,  A61K47/26

CPC classification number: C07K16/2896 ,  A61K47/22 ,  A61K47/12 ,  A61K47/26 ,  C07K2317/35 ,  C07K2317/92 ,  C07K2317/76 ,  C07K2317/73

Abstract: The present invention provides pharmaceutical formulations comprising antibodies binding to CD38 and to the use of said formulations in the treatment of cancer and other indications.

公开(公告)号：US20230027394A1

公开(公告)日：2023-01-26

申请号：US17739934

申请日：2022-05-09

Applicant: GENMAB A/S

Inventor： Rik RADEMAKER ,  Isil Altintas ,  Patrick Engelberts ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/28 ,  C07K16/32

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.

公开(公告)号：US20220411505A1

公开(公告)日：2022-12-29

申请号：US17635258

申请日：2020-08-14

Applicant: GENMAB A/S

Inventor： Jesper VALBJOERN ,  Lene Schantz HARLOW ,  Jacob Dahlqvist CLAUSEN ,  Mette Hamborg JENSEN ,  Christian CIMANDER ,  Jesper PASS ,  Peter Juul MADSEN ,  Shan REN ,  Maria Anna Cecilia WAHLBOM ,  Bolette BJERREGAARD

IPC: C07K16/28 ,  A61P35/00

Abstract: The present invention relates to improved pharmaceutical compositions and dosage unit forms of bispecific CD3×CD20 antibodies and to routes of administration.

公开(公告)号：US11440966B2

公开(公告)日：2022-09-13

申请号：US17345628

申请日：2021-06-11

Applicant: GENMAB A/S ,  BioNTech SE

Inventor： Isil Altintas ,  David Satijn ,  Rik Rademaker ,  Paul Parren ,  Friederike Gieseke ,  Ugur Sahin

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/569

Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.