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公开(公告)号：US11845805B2
公开(公告)日：2023-12-19
申请号：US17558430
申请日：2021-12-21
Applicant: GENMAB A/S
Inventor： Brian Elliott , Tahamtan Ahmadi , Christopher W. L. Chiu , Esther C. W Breij , Ida Hiemstra , Maria N. Jure-Kunkel
IPC: A61P35/00 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , C07K16/28 , A61K39/395 , A61K39/00
CPC classification number: C07K16/2887 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , A61K39/3955 , A61P35/00 , C07K16/2809 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/24 , C07K2317/31 , C07K2317/565
Abstract: Provided are methods of clinical treatment of diffuse large B-cell lymphoma (DLBCL) (e.g., previously untreated, high-risk DLBCL) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of care regimen of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone).
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2.发明授权公开(公告)号：US11608383B2
公开(公告)日：2023-03-21
申请号：US17559938
申请日：2021-12-22
Applicant: GENMAB A/S
Inventor： Brian Elliott , Tahamtan Ahmadi , Christopher W. L. Chiu , Esther C. W. Breij , Ida Hiemstra , Maria N. Jure-Kunkel
IPC: A61K39/40 , A61K39/395 , C07K16/28 , A61K31/454 , C07K16/00
Abstract: Provided are methods of clinical treatment of follicular lymphoma (for example, relapsed and/or refractory follicular lymphoma) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of care regimens of rituximab and lenalidomide.
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公开(公告)号：US11858995B2
公开(公告)日：2024-01-02
申请号：US17559935
申请日：2021-12-22
Applicant: GENMAB A/S
Inventor： Brian Elliott , Jenny Jianlin Chen , Tahamtan Ahmadi , Christopher W. L. Chiu , Esther C. W. Breij , Ida Hiemstra , Maria N. Jure-Kunkel
CPC classification number: C07K16/2809 , C07K16/2887 , A61K2039/507 , A61K2039/545 , C07K2317/24 , C07K2317/31
Abstract: Provided are methods of clinical treatment of chronic lymphoblastic leukemia (CLL) in human subjects using a bispecific antibody which binds to CD3 and CD20.
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