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公开(公告)号：US20210177987A1
公开(公告)日：2021-06-17
申请号：US16760373
申请日：2018-11-01
Applicant: Genmab A/S
Inventor： Reshma Abdulla RANGWALA , Steen LISBY
Abstract: The invention provides methods and compositions for treating cancer, such as advanced cervical cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., advanced cervical cancer).
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公开(公告)号：US20210163616A1
公开(公告)日：2021-06-03
申请号：US17172694
申请日：2021-02-10
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK , Christian GRUNWITZ
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20210155699A1
公开(公告)日：2021-05-27
申请号：US17099328
申请日：2020-11-16
Applicant: Genmab A/S
Inventor： Aran Frank LABRIJN , Stefan LOVERIX , Paul PARREN , Jan VAN DE WINKEL , Janine SCHUURMAN , Ignace LASTERS
IPC: C07K16/28 , C07K16/00 , A61K39/395 , A61K51/10 , A61K47/68
Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
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公开(公告)号：US20210107980A1
公开(公告)日：2021-04-15
申请号：US17053346
申请日：2019-05-07
Applicant: Genmab A/S
Inventor： Reshma Abdulla RANGWALA , Esther C.W. BREIJ , Sandra VERPLOEGEN , Oyewale O. ABIDOYE , Leonardo Viana NICACIO , Anthony CAO , Shyra GARDAI
Abstract: The invention provides an anti-PD-1 antibody in combination with an antibody-drug conjugate that binds to tissue factor (TF) (e.g., tisotumab vedotin) and their use in methods of treating cancer, such as breast cancer and cervical cancer. The invention also provides compositions and kits comprising the anti-PD-1 antibody and the antibody-drug conjugate that binds to TF (e.g., tisotumab vedotin) for use in treating cancer, such as breast cancer and cervical cancer.
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公开(公告)号：US10968280B2
公开(公告)日：2021-04-06
申请号：US16779011
申请日：2020-01-31
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil Altintas , David Satijn , Rik Rademaker , Paul Parren , Ugur Sahin , Friederike Gieseke , Alexander Muik , Christian Grunwitz
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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Patent Agency Ranking
公开(公告)号：US20210070877A1
公开(公告)日：2021-03-11
申请号：US17077376
申请日：2020-10-22
Applicant: GENMAB A/S
Inventor： David SATIJN , Esther C. W. BREIJ , Bart E. C. G. DE GOEIJ , Kristel KEMPER , Patrick ENGELBERTS , Edward N. VAN DEN BRINK , Rik RADEMAKER , Dennis VERZIJL , Sjeng HORBACH , Paul PARREN
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US20200332022A1
公开(公告)日：2020-10-22
申请号：US16783720
申请日：2020-02-06
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Joost J. NEIJSSEN , Edward Norbert VAN DEN BRINK , Janine SCHUURMAN , Paul PARREN
Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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公开(公告)号：US20200247899A1
公开(公告)日：2020-08-06
申请号：US16855703
申请日：2020-04-22
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US20200239579A1
公开(公告)日：2020-07-30
申请号：US16491464
申请日：2018-03-09
Applicant: GENMAB A/S
Inventor： Isil ALTINTAS , David SATIJN , Edward VAN DEN BRINK , Dennis VERZIJL , Rik RADEMAKER , Paul PARREN , Bart DE GOEIJ
IPC: C07K16/28 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/42
Abstract: The present invention relates to novel antibodies and their use in medicine. In particular, the invention relates to bispecific antibodies capable of binding human PD-L1 and capable of binding human CD3. Novel classes of antibodies capable of binding human PD-L1 are also provided. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20200171152A1
公开(公告)日：2020-06-04
申请号：US16673383
申请日：2019-11-04
Applicant: GENMAB A/S
Inventor： Esther BREIJ , David SATIJN , Edward Norbert VAN DEN BRINK , Dennis VERZIJL , Rob N. DE JONG , Paul PARREN , Riemke VAN DIJKHUIZEN RADERSMA
IPC: A61K39/395 , C07K16/28 , A61K47/68 , C07K16/30
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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