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21.发明申请siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2) 审中-公开靶向核糖核苷酸还原酶M2多肽（RRM2或RNR-R2）公开(公告)号：US20100248990A1
公开(公告)日：2010-09-30
申请号：US12462776
申请日：2009-08-07
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC分类号： C12N15/111 , A61K31/713 , C07H21/00 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/11 , C12N2330/30 , C12Y304/21047 , G16B20/00
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to RRM2.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对RRM2的那些。
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公开(公告)号：US20100240554A1
公开(公告)日：2010-09-23
申请号：US12798906
申请日：2010-04-13
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G06F19/18
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for GCGR.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对GCGR的核苷酸序列的那些。
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公开(公告)号：US20100234582A1
公开(公告)日：2010-09-16
申请号：US12798603
申请日：2010-04-07
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G06F19/18
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to CKSF1B1.
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公开(公告)号：US20100197023A1
公开(公告)日：2010-08-05
申请号：US12626011
申请日：2009-11-25
申请人： Devin Leake , Angela Reynolds , Anastasia Khvorova , William Marshall , Yuriy Fedorov , Kimberly Nichols
发明人： Devin Leake , Angela Reynolds , Anastasia Khvorova , William Marshall , Yuriy Fedorov , Kimberly Nichols
CPC分类号： C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2320/11 , C12N2330/30 , C12Y207/11024 , C12Y301/03001 , C12N2310/3521
摘要： Methods and compositions for performing RNA interference comprising a wide variety of stabilized siRNAs suitable for use in serum-containing media and for in vivo applications, such as therapeutic applications, are provided. These siRNAs permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of one or more modifications including orthoesters, terminal conjugates, modified linkages and 2′ modified nucleotides. Uniquely modified siRNAs have been developed that reduces off-target effects incurred in gene-silencing. The modifications include phosphorylation of the first 5′ terminal antisense nucleotide; 2′ carbon modifications of the first and second or first, second, and third 5′ terminal antisense nucleotides; and optionally 2′ carbon modifications of the first and second or first, second, and third 5′ terminal sense nucleotide. Control and exaequo molecules are also provided. siRNA molecules and related control, trackability and exaequo agents with specific stability modifications were developed.
摘要翻译： 提供了用于进行RNA干扰的方法和组合物，其包含适用于含血清培养基和体内应用（例如治疗应用）的多种稳定的siRNA。 这些siRNA允许通过使用一种或多种修饰，包括原酸酯，末端缀合物，经修饰的连接和2'修饰的核苷酸，有效和有效地应用RNA干扰到诸如诊断和治疗之类的应用。 已经开发了独特修饰的siRNA，其减少在基因沉默中引起的脱靶效应。 修饰包括前5'末端反义核苷酸的磷酸化; 第二个或第二个，第二个和第三个5'末端反义核苷酸的2'碳修饰; 和任选的第二个或第二个，第二个，第二个和第三个5'末端有义核苷酸的2'碳修饰。 还提供对照和exaequo分子。 开发了具有特异性稳定性修饰的siRNA分子和相关对照，可追踪性和exaequo剂。
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公开(公告)号：US20100113761A1
公开(公告)日：2010-05-06
申请号：US12653402
申请日：2009-12-11
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G06F19/18
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for BACE.
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公开(公告)号：US20100113760A1
公开(公告)日：2010-05-06
申请号：US12653120
申请日：2009-12-08
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G06F19/18
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for MYD88.
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公开(公告)号：US20100113307A1
公开(公告)日：2010-05-06
申请号：US12653530
申请日：2009-12-15
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC分类号： C12N15/111 , C12N15/113 , C12N15/1135 , C12N2310/14 , C12N2320/11 , G16B20/00
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to VEGF.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对VEGF的那些。
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公开(公告)号：US20100113306A1
公开(公告)日：2010-05-06
申请号：US12655107
申请日：2009-12-23
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G06F19/18
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to CTGF.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对CTGF的那些。
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公开(公告)号：US20100087335A1
公开(公告)日：2010-04-08
申请号：US12592335
申请日：2009-11-23
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Stephen Scaringe , Steven Read
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Stephen Scaringe , Steven Read
CPC分类号： C12Y113/12007 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y502/01008 , G06F19/18
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过基本设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。
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30.发明申请siRNA targeting TATA box binding protein (TBP)-associated factor (TAF1) 有权针对TATA盒结合蛋白（TBP）相关因子（TAF1）的siRNA公开(公告)号：US20100075869A1
公开(公告)日：2010-03-25
申请号：US12590707
申请日：2009-11-12
申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC分类号： C12Y113/12007 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y502/01008 , G06F19/18
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TAF1
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对TAF1的核苷酸序列的那些
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