公开(公告)号：US09810702B2

公开(公告)日：2017-11-07

申请号：US14858111

申请日：2015-09-18

Applicant: Cleveland HeartLab, Inc.

Inventor： Cory Bystrom ,  Timothy Collier

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2333/775

Abstract: Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.

公开(公告)号：US07647234B1

公开(公告)日：2010-01-12

申请号：US09534946

申请日：2000-03-24

Applicant: Frank R. Ruderman ,  David T. Shewmake

Inventor： Frank R. Ruderman ,  David T. Shewmake

IPC: G06Q50/00

CPC classification number: G06F19/3456 ,  G06F19/00 ,  G06F19/325 ,  G06F19/326 ,  G06F19/3418 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  Y10S706/924

Abstract: The disclosure relates to an interactive, web based cardiovascular healthcare management system which has an infomediary site with databases having information relating to cardiovascular disease risk factors such as age, blood pressure, LDL, HDL and subfractions thereof and cardiovascular disease management such as diet, exercise, drugs and cardiovascular education materials. The physician can communicate electronically with the infomediary site to obtain patient test results and formulate a patient treatment plan from the diet, exercise and drug data. The physician can electronically communicate treatment plans to the patient through a record in the infomediary site. The patient can electronically communicate compliance information to the physician through the patient record. The infomediary site may also provide a case manager to provide initial draft treatment plans to the physician, gather patient history data and/or patient treatment plan compliance data.

Abstract translation: 本公开涉及一种基于互联网的心血管健康管理系统，其具有信息站点，其具有数据库，其具有与心血管疾病危险因素有关的信息，例如年龄，血压，LDL，HDL及其分数，以及心血管疾病管理，例如饮食，运动 药物和心血管教育材料。 医师可以与信息网站进行电子通信，以获得患者测试结果，并从饮食，运动和药物数据中制定患者治疗计划。 医生可以通过信息网站的记录将治疗计划电子化地传达给病人。 患者可以通过患者记录将合规信息以电子方式传达给医师。 信息网站还可以提供病例管理者向医师提供初始治疗计划草案，收集患者病史数据和/或患者治疗计划合规性数据。

公开(公告)号：US20080021740A1

公开(公告)日：2008-01-24

申请号：US11774143

申请日：2007-07-06

Applicant: John Beane ,  Larry Heminger ,  Robert Stone

Inventor： John Beane ,  Larry Heminger ,  Robert Stone

IPC: G06F19/00

CPC classification number: G06F19/321 ,  G06F19/3418 ,  G06Q50/24

Abstract: As patient video images are captured in a lab, they are converted into an uncompressed data set and stored locally on a hospital site server, where they are immediately viewable by diagnosticians in the hospital. The hospital site server generates a plurality of compressed data sets for use by the Internet Data Center. Additionally, the uncompressed data set and a plurality of compressed data sets are stored permanently on a centralized Internet Data Center, from which they can be searched out and displayed by any client device running web-browser software. A client is provided with immediate access to the uncompressed images when pausing and requesting the images of interest from the server. The patient video images are automatically delivered to any authorized Clinical Research Organizations, they are delivered back to the treating hospital when the patient returns for subsequent visits, and are viewable through in-hospital viewing stations over a private high-speed network.

Abstract translation: 由于患者的视频图像在实验室中被捕获，所以将它们转换为未压缩的数据集，并将其存储在医院现场服务器上，并立即由医院诊断人员查看。 医院站点服务器生成多个压缩数据集供互联网数据中心使用。 此外，未压缩数据集和多个压缩数据集被永久地存储在集中式互联网数据中心上，由运行网络浏览器软件的任何客户端设备可从中搜索出并显示。 当客户端暂停并请求服务器感兴趣的图像时，可以立即访问未压缩映像。 患者视频图像自动传送到任何授权的临床研究组织，当患者返回后续访问时，他们被送回治疗医院，并可通过私人高速网络通过医院内观察站查看。

公开(公告)号：US07277903B2

公开(公告)日：2007-10-02

申请号：US09920973

申请日：2001-08-02

Applicant: Robert R. Petrocelli

Inventor： Robert R. Petrocelli

IPC: G06F17/30 ,  G06F17/00

CPC classification number: G06F19/321 ,  G06F19/00 ,  Y10S707/99945 ,  Y10S707/99955

Abstract: An archive system is provided for long term storage of large amounts of data that is particularly suited for multi-year storage of medical data such as cardiac images, patient demographics and reports. One or more digital versatile disks (DVDs) may be employed as the storage media. In the archival process, all of the data for a particular patient, procedure or study is stored and uniquely identified within one DVD. Each DVD may have an executable program stored thereon for independently accessing the archived data from the selected DVD. Before the DVD is recorded, the data to be archived is segmented into a plurality of information groups where each group is based on data for the particular patient, procedure or study. Then, the DVD is reviewed to determine whether a sufficient amount of storage space is present to ensure that the information group will be entirely stored within one DVD.

Abstract translation: 提供存档系统用于长期存储大量数据，特别适用于诸如心脏图像，患者人口统计和报告的医疗数据的多年存储。 可以使用一个或多个数字通用盘（DVD）作为存储介质。 在归档过程中，特定患者，程序或研究的所有数据在一张DVD内存储和唯一标识。 每个DVD可以具有存储在其上的可执行程序，用于独立地从所选择的DVD访问归档数据。 在记录DVD之前，要归档的数据被分割成多个信息组，其中每个组基于特定患者，程序或研究的数据。 然后，检查DVD以确定是否存在足够的存储空间以确保信息组将完全存储在一个DVD内。

公开(公告)号：US20070071643A1

公开(公告)日：2007-03-29

申请号：US11522589

申请日：2006-09-18

Applicant: Christopher Hall ,  Vance Lanier ,  David Shewmake ,  Frank Ruderman ,  Matthew Banet ,  Randon Schultz ,  Marshal Dhillon ,  Adam Fleming ,  Henk Visser

Inventor： Christopher Hall ,  Vance Lanier ,  David Shewmake ,  Frank Ruderman ,  Matthew Banet ,  Randon Schultz ,  Marshal Dhillon ,  Adam Fleming ,  Henk Visser

IPC: G01N33/00

CPC classification number: G06F19/3418 ,  G06F19/3456 ,  G06F19/3475 ,  G16H10/60 ,  G16H15/00 ,  G16H40/63 ,  G16H50/20

Abstract: The invention provides a system for monitoring a patient that includes: 1) a first database that stores the patient's blood test information; 2) a monitoring device that collects the patient's cardiovascular and exercise information; 3) a second database that receives cardiovascular and exercise information from the monitoring device; and 4) an Internet-based system that displays the blood test, cardiovascular, and exercise information.

Abstract translation: 本发明提供了一种用于监测患者的系统，包括：1）存储患者血液测试信息的第一数据库; 2）收集患者心血管和运动信息的监测装置; 3）从监测装置接收心血管和运动信息的第二数据库; 以及4）基于互联网的系统，显示血液测试，心血管和运动信息。

公开(公告)号：US20060161067A1

公开(公告)日：2006-07-20

申请号：US11335870

申请日：2006-01-18

Applicant: Jonathan Elion

Inventor： Jonathan Elion

IPC: A61B5/04

CPC classification number: A61B5/044 ,  A61B5/0452 ,  A61B5/7435 ,  A61B5/7445

Abstract: A system allows for the prioritization of ECGs. This can be performed by the ECG management system and/or at the instruction of the cardiologist or other reader. In a current implementation, the system will allow for the sorting of the ECGs so that the more complex interpretations are presented first, when the cardiologist or other reader is not suffering from fatigue, saving the simpler readings for later in the session as fatigue might begins to become a factor.

Abstract translation: 系统允许对ECG进行优先排序。 这可以由ECG管理系统和/或在心脏病专家或其他读者的指导下执行。 在目前的实施中，系统将允许对ECG进行分类，以便当心脏病专家或其他读者没有遭受疲劳时首先呈现更复杂的解释，从而在疲劳可能开始时节省更短的读数 成为一个因素。

公开(公告)号：US20050009193A1

公开(公告)日：2005-01-13

申请号：US10854402

申请日：2004-05-26

Applicant: Amy Roberts ,  David Shewmake

Inventor： Amy Roberts ,  David Shewmake

IPC: G01N33/92 ,  G06Q10/00 ,  G06F17/60

CPC classification number: G06Q10/10 ,  G01N33/92 ,  G01N2800/044 ,  G06F19/00 ,  G06Q50/24

Abstract: The invention provides novel methods for selecting an optimal diet and exercise regimen for a patient based on the consideration of several factors, including low density lipoprotein (LDL) and high density lipoprotein (HDL) subclass levels. Furthermore, the invention provides novel methods for treating a patient, comprising selecting an optimal diet and exercise regimen and monitoring the patient. Patients appropriate for the methods of the invention include, for example, those with cardiovascular disease (CVD) or at risk of developing CVD. In contrast to prior methods, the methods of the invention are based on the measurement of risk factors, including LDL and HDL subclass levels, that have not previously been used to select a diet and exercise regimen.

Abstract translation: 本发明提供了基于对低密度脂蛋白（LDL）和高密度脂蛋白（HDL）亚类水平的几个因素的考虑，为患者选择最佳饮食和运动方案的新方法。 此外，本发明提供了治疗患者的新方法，包括选择最佳饮食和运动方案并监测患者。 适用于本发明方法的患者包括例如具有心血管疾病（CVD）或有发展CVD风险的患者。 与现有方法相反，本发明的方法是基于以前未用于选择饮食和运动方案的危险因素（包括LDL和HDL亚类水平）的测量。

公开(公告)号：US20030194812A1

公开(公告)日：2003-10-16

申请号：US10122081

申请日：2002-04-12

Applicant: Berkeley HeartLab, Inc.

Inventor： David Shewmake ,  Frank Ruderman ,  Christopher Boggess

IPC: G01N033/92

CPC classification number: G01N33/92 ,  G01N2800/32 ,  G01N2800/52

Abstract: The invention provides a method for identifying patients with normal NCEP lipid levels who are in need of treatment for cardiovascular disease comprising measuring one or more LDL or HDL particle subclass levels and identifying abnormal LDL or HDL subclass levels. LDL III anullb and HDL 2b are preferred subclasses.

Abstract translation: 本发明提供了一种用于鉴定需要治疗心血管疾病的正常NCEP脂质水平的患者的方法，包括测量一种或多种LDL或HDL颗粒亚类水平并鉴定异常的LDL或HDL亚类水平。 LDL III a + b和HDL 2b是优选的亚类。

公开(公告)号：US20020046215A1

公开(公告)日：2002-04-18

申请号：US09920973

申请日：2001-08-02

Applicant: HEARTLAB, INC.

Inventor： Robert R. Petrocelli

IPC: G06F012/00

CPC classification number: G06F19/321 ,  G06F19/00 ,  Y10S707/99945 ,  Y10S707/99955

Abstract: An archive system is provided for long term storage of large amounts of data that is particularly suited for multi-year storage of medical data such as cardiac images, patient demographics and reports. One or more digital versatile disks (DVDs) may be employed as the storage media. In the archival process, all of the data for a particular patient, procedure or study is stored and uniquely identified within one DVD. Each DVD may have an executable program stored thereon for independently accessing the archived data from the selected DVD. Before the DVD is recorded, the data to be archived is segmented into a plurality of information groups where each group is based on data for the particular patient, procedure or study. Then, the DVD is reviewed to determine whether a sufficient amount of storage space is present to ensure that the information group will be entirely stored within one DVD.

Abstract translation: 提供存档系统用于长期存储大量数据，特别适用于诸如心脏图像，患者人口统计和报告的医疗数据的多年存储。 可以使用一个或多个数字通用盘（DVD）作为存储介质。 在归档过程中，特定患者，程序或研究的所有数据在一张DVD内存储和唯一标识。 每个DVD可以具有存储在其上的可执行程序，用于独立地从所选择的DVD访问归档数据。 在记录DVD之前，要归档的数据被分割成多个信息组，其中每个组基于特定患者，程序或研究的数据。 然后，检查DVD以确定是否存在足够的存储空间以确保信息组将完全存储在一个DVD内。

公开(公告)号：US20250107771A1

公开(公告)日：2025-04-03

申请号：US18834815

申请日：2022-11-24

Applicant: Hidetsugu ASANOI ,  HEARTLAB, INC.

Inventor： Hidetsugu ASANOI

IPC: A61B7/04 ,  A61B5/00

Abstract: A heart sound analysis device 3 that analyzes a heart sound signal acquired from a subject comprises an amplitude variation waveform generation unit 33a that generates an amplitude variation waveform of the heart sound signal; a peak detection unit 33b that detects maximum peaks in the amplitude variation waveform; a time interval calculation unit 33c that calculates time intervals between the maximum peaks; and a prediction support unit 33d that supports the prediction of the state of the subject based on the time intervals.