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    COMPOSITIONS AND METHODS FOR PURIFICATION AND DETECTION OF HDL AND APOAI
    1.
    发明申请
    COMPOSITIONS AND METHODS FOR PURIFICATION AND DETECTION OF HDL AND APOAI 有权

    公开(公告)号：US20250027960A1

    公开(公告)日：2025-01-23

    申请号：US18829111

    申请日：2024-09-09

    Applicant: CLEVELAND HEARTLAB, INC.

    Inventor： Timothy Collier ,  Cory Bystrom ,  Angela Higgins

    IPC: G01N33/92 ,  C07K14/775 ,  G01N1/34

    Abstract: The present invention provides methods, kits, and compositions for purifying HDL molecules from a sample (e.g., blood sample) using HDL tagging molecules comprising an HDL lipophilic core binding peptide (e.g., portion of ApoA1) and an affinity tag. The present invention also provides methods, kits, and compositions for detecting non-fragmented ApoA1 with mass spectrometry. The present invention further provides methods, kits, and compositions for tagging HDL molecules in a sample with detectably labeled ApoA1 molecules such that the ratio of detectably labeled ApoA1 molecules to native ApoA1 proteins may be determined.

    HDL-ASSOCIATED PROTEIN EXTRACTION AND DETECTION
    3.
    发明公开
    HDL-ASSOCIATED PROTEIN EXTRACTION AND DETECTION 审中-公开

    公开(公告)号：US20240310391A1

    公开(公告)日：2024-09-19

    申请号：US18615987

    申请日：2024-03-25

    Applicant: CLEVELAND HEARTLAB, INC.

    Inventor： Cory Bystrom ,  Timothy COLLIER

    IPC: G01N33/92

    CPC classification number: G01N33/92 ,  G01N2333/775

    Abstract: Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.

    HDL-associated protein extraction and detection
    5.
    发明授权
    HDL-associated protein extraction and detection 有权

    公开(公告)号：US11940452B2

    公开(公告)日：2024-03-26

    申请号：US16667016

    申请日：2019-10-29

    Applicant: CLEVELAND HEARTLAB, INC.

    Inventor： Cory Bystrom ,  Timothy Collier

    IPC: G01N33/92

    CPC classification number: G01N33/92 ,  G01N2333/775

    Abstract: Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.

    COMPOSITIONS AND METHODS FOR PURIFICATION AND DETECTION OF HDL AND APOAI
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR PURIFICATION AND DETECTION OF HDL AND APOAI 有权

    公开(公告)号：US20210373038A1

    公开(公告)日：2021-12-02

    申请号：US17367049

    申请日：2021-07-02

    Applicant: CLEVELAND HEARTLAB, INC.

    Inventor： Timothy Collier ,  Cory Bystrom ,  Angela Higgins

    IPC: G01N33/92 ,  G01N1/34

    Abstract: The present invention provides methods, kits, and compositions for purifying HDL molecules from a sample (e.g., blood sample) using HDL tagging molecules comprising an HDL lipophilic core binding peptide (e.g., portion of ApoA1) and an affinity tag. The present invention also provides methods, kits, and compositions for detecting non-fragmented ApoA1 with mass spectrometry. The present invention further provides methods, kits, and compositions for tagging HDL molecules in a sample with detectably labeled ApoA1 molecules such that the ratio of detectably labeled ApoA1 molecules to native ApoA1 proteins may be determined.

    Method for identifying patients who will require multiple invasive cardiovascular procedures
    7.
    发明申请
    Method for identifying patients who will require multiple invasive cardiovascular procedures 审中-公开
    确定需要多次侵入性心血管手术的患者的方法

    公开(公告)号：US20040043496A1

    公开(公告)日：2004-03-04

    申请号：US10463664

    申请日：2003-06-16

    Applicant: Berkeley HeartLab, Inc.

    Inventor： H. Robert Superko

    IPC: G01N033/92

    CPC classification number: G01N33/92 ,  G01N2800/52

    Abstract: The invention provides a method for identifying patients who will require multiple invasive cardiac procedures comprising measuring elevated LDL IVb levels in patients who have had or will have invasive heart surgery.

    Abstract translation: 本发明提供了一种用于鉴定需要多次侵入性心脏手术的患者的方法，包括测量已经或将要进行侵入性心脏手术的患者的升高的LDL IVb水平。

    Device for calculating respiratory waveform information and medical instrument using respiratory waveform information
    9.
    发明授权
    Device for calculating respiratory waveform information and medical instrument using respiratory waveform information 有权

    公开(公告)号：US11571533B2

    公开(公告)日：2023-02-07

    申请号：US16134369

    申请日：2018-09-18

    Applicant: Hidetsugu Asanoi ,  HEARTLAB, INC.

    Inventor： Hidetsugu Asanoi

    IPC: A61B5/087 ,  A61M16/00 ,  G16Z99/00 ,  A61B5/08 ,  A61B5/00 ,  A61M16/10

    Abstract: Provided is a configuration capable of executing a detection test for a comfort level including the quality of sleep, which is measurable at home without requiring the measurement of brain waves or electrocardiogram. The respiratory waveform of a subject during sleep is continuously measured and recorded from the respiratory gas flow, etc., and is window-Fourier transformed at each measurement time to generate a frequency spectrum, and a bandwidth including a respiratory frequency is extracted. The index indicating the regularity of the respiratory period of the subject is also calculated at each time point during the sleep, and the time-dependency of this index during the sleep is represented as a graph. A medical device includes a sleep evaluation system equipped with a control means for performing control so that a sleep cycle repeated at a cycle of about 90 minutes is clearly observed if the comfort level including the quality of sleep of the subject is favorable.

    Lp-PLA2 ASSAYS AND COMPOSITION WITH DETERGENT
    10.
    发明申请
    Lp-PLA2 ASSAYS AND COMPOSITION WITH DETERGENT 有权

    公开(公告)号：US20220155302A1

    公开(公告)日：2022-05-19

    申请号：US17588925

    申请日：2022-01-31

    Applicant: CLEVELAND HEARTLAB, INC.

    Inventor： Celalettin Topbas ,  Cory Bystrom

    IPC: G01N33/573 ,  G01N1/28

    Abstract: Provided herein are methods, systems, and compositions for Lp-PLA2 detection assays that employ amounts of detergent to liberate all or nearly all of the Lp-PLA2 molecules from associated lipoprotein particles. In this regard, the true Lp-PLA2 concentration can be detected in a sample, which correlates better with known Lp-PLA2 activity assays.

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