公开(公告)号：US08470848B2

公开(公告)日：2013-06-25

申请号：US12699686

申请日：2010-02-03

Applicant: Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham ,  Katharine Louise Turner ,  Simon James Watson ,  Lyndon Nigel Brown ,  Brian Cox

Inventor： Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham ,  Katharine Louise Turner ,  Simon James Watson ,  Lyndon Nigel Brown ,  Brian Cox

IPC: A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K45/06

Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.

Abstract translation: 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书 制备方法，以及作为药物的用途。

公开(公告)号：US07888383B2

公开(公告)日：2011-02-15

申请号：US12096332

申请日：2006-12-07

Applicant: David Andrew Sandham

Inventor： David Andrew Sandham

IPC: C07D413/12 ,  C07D403/12 ,  C07D209/22 ,  A61K31/5377 ,  A61K31/405

CPC classification number: C07D209/10

Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R4, R5, R6, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.

Abstract translation: 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 4，R 5，R 6，D，X，W，m和n如说明书中所述，其制备方法 ，以及作为药物的用途。

公开(公告)号：US20100204225A1

公开(公告)日：2010-08-12

申请号：US12699686

申请日：2010-02-03

Applicant: Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham ,  Katharine Louise Turner ,  Simon James Watson ,  Lyndon Nigel Brown ,  Brian Cox

Inventor： Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham ,  Katharine Louise Turner ,  Simon James Watson ,  Lyndon Nigel Brown ,  Brian Cox

IPC: A61K31/5377 ,  A61K31/437 ,  A61P29/00 ,  A61P11/08 ,  A61P11/14

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K45/06

Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.

Abstract translation: 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书 制备方法，以及作为药物的用途。

公开(公告)号：US07666878B2

公开(公告)日：2010-02-23

申请号：US11597781

申请日：2005-06-16

Applicant: Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham ,  Katharine Louise Turner ,  Simon James Watson ,  Lyndon Nigel Brown ,  Brian Cox

Inventor： Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham ,  Katharine Louise Turner ,  Simon James Watson ,  Lyndon Nigel Brown ,  Brian Cox

IPC: C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K45/06

Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R 4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.

Abstract translation: 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如 规格，制备方法及其作为药物的用途。

公开(公告)号：US20080312322A1

公开(公告)日：2008-12-18

申请号：US11915091

申请日：2006-05-22

Applicant: Urs Baettig ,  Brian Cox ,  Katharine Louise Turner ,  Simon James Watson ,  Diana Janus ,  Catherine Leblanc ,  David Andrew Sandham

Inventor： Urs Baettig ,  Brian Cox ,  Katharine Louise Turner ,  Simon James Watson ,  Diana Janus ,  Catherine Leblanc ,  David Andrew Sandham

IPC: A61K31/216 ,  C07C59/40 ,  A61K31/19 ,  A61P37/00 ,  A61P29/00 ,  C07C69/76

CPC classification number: C07C317/22 ,  C07C59/70 ,  C07C69/712 ,  C07C205/37 ,  C07C235/22 ,  C07C323/20 ,  C07C2601/02

Abstract: A compound of formula (I); in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.

Abstract translation: 式（I）化合物; 其中R 1，R 2，R 3，R 4，R 5，m，n，w，X，Y和Q具有如说明书中所示的含义，可用于治疗CRTh2受体介导的病症， 特别是炎性或阻塞性气道疾病。

公开(公告)号：US20080200466A1

公开(公告)日：2008-08-21

申请号：US11915168

申请日：2006-05-22

Applicant: Jake Axford ,  Urs Baettig ,  Brian Cox ,  Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham

Inventor： Jake Axford ,  Urs Baettig ,  Brian Cox ,  Kamlesh Jagdis Bala ,  Catherine Leblanc ,  David Andrew Sandham

IPC: A61K31/5375 ,  C07D207/16 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07D241/04 ,  C07D211/06 ,  C07D265/30

CPC classification number: C07D295/185

Abstract: Compounds of formula (I) in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, R6, R7, m, n, w, X, and Y have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.

Abstract translation: 游离或药学上可接受的盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，m，n，w，X和Y具有如上所述的含义 在本说明书中，可用于治疗由CRTH2受体介导的病症，特别是炎性或阻塞性气道疾病。