公开(公告)号：US20240199575A1

公开(公告)日：2024-06-20

申请号：US18549398

申请日：2022-03-08

Applicant: ABIONYX PHARMA SA

Inventor： Jean-Louis Henri Dasseux

IPC: C07D401/04 ,  A61K31/095 ,  A61K31/4192 ,  A61K31/426 ,  A61K31/4439 ,  A61P3/10 ,  C07C323/20 ,  C07D249/06 ,  C07D277/24

CPC classification number: C07D401/04 ,  A61K31/095 ,  A61K31/4192 ,  A61K31/426 ,  A61K31/4439 ,  A61P3/10 ,  C07C323/20 ,  C07D249/06 ,  C07D277/24

Abstract: This invention provides compounds, for example, of Formulae (A)-(H) and (J)-(AA) and pharmaceutically acceptable salts, solvates, esters, amides, and prodrugs thereof. The invention further provides pharmaceutical compositions comprising a compound of the invention, and a pharmaceutically acceptable carrier or vehicle. The compounds and compositions disclosed herein are useful for treating or preventing various diseases and conditions, for example liver disease such as liver fibrosis, fatty liver disease, non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH), and kidney diseases such as acute kidney injury (AKI).

公开(公告)号：US20190233382A1

公开(公告)日：2019-08-01

申请号：US16342280

申请日：2017-10-16

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Daniel GALLENKAMP ,  Mark James FORD

IPC: C07D257/06 ,  C07C323/09 ,  C07C323/62

CPC classification number: C07D257/06 ,  C07C319/14 ,  C07C323/09 ,  C07C323/20 ,  C07C323/62

Abstract: The invention relates to a method for producing 3-alkylsulfanyl-2-chloro-N-(1-alkyl-1H-tetrazol-5-yl)-4-trifluoromethyl-benzamides of formula (I). In said formula, the substituents R1 and R2 represent residues such as alkyl and substituted phenyl.

公开(公告)号：US09904167B2

公开(公告)日：2018-02-27

申请号：US14982759

申请日：2015-12-29

Applicant: FUJIFILM Corporation

Inventor： Tomotaka Tsuchimura

IPC: G03F7/004 ,  H01L21/027 ,  C07D327/08 ,  C07C309/15 ,  C07D333/76 ,  C07C311/16 ,  C07C327/24 ,  C07C381/12 ,  C07D209/48 ,  C07D333/46 ,  C07D335/16 ,  C07D339/08 ,  C07C311/14 ,  C07D347/00 ,  C07C311/48 ,  C07C311/51 ,  C07C327/22 ,  C07C327/26 ,  C07D493/08 ,  C07C25/18 ,  C07J31/00 ,  C07J41/00 ,  C07C309/19 ,  C07C321/28 ,  C07C323/09 ,  C07C323/20 ,  H01L29/16 ,  G03F7/038 ,  G03F7/039

CPC classification number: G03F7/0045 ,  C07C25/18 ,  C07C309/15 ,  C07C309/19 ,  C07C311/14 ,  C07C311/16 ,  C07C311/48 ,  C07C311/51 ,  C07C321/28 ,  C07C323/09 ,  C07C323/20 ,  C07C327/22 ,  C07C327/24 ,  C07C327/26 ,  C07C381/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/18 ,  C07C2603/24 ,  C07C2603/74 ,  C07D209/48 ,  C07D327/08 ,  C07D333/46 ,  C07D333/76 ,  C07D335/16 ,  C07D339/08 ,  C07D347/00 ,  C07D493/08 ,  C07J31/006 ,  C07J41/0055 ,  C07J41/0061 ,  G03F1/76 ,  G03F7/038 ,  G03F7/0382 ,  G03F7/0392 ,  G03F7/0397 ,  H01L21/0271 ,  H01L21/0276 ,  H01L29/16

Abstract: Provided is an active light sensitive or radiation sensitive resin composition which contains a compound (A) represented by General Formula (I) or (II): in the formulae, each of Y1 and Y2 represents a monovalent organic group; each of M1+ and M2+ represents an organic onium ion; each of X1 and X2 represents a group that is represented by —S—, —NH—, or —NR1—; R1 represents a monovalent organic group; each of n1 and n2 represents an integer of 1 or more; and R1 and Y1 or Y2 may bond with each other to form a ring.

公开(公告)号：US20170320898A1

公开(公告)日：2017-11-09

申请号：US15607826

申请日：2017-05-30

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Neil Hukriede ,  Billy W. Day ,  Lee A. McDermott

IPC: C07F9/48 ,  C07C323/62 ,  C07C323/60 ,  C07C323/52 ,  C07C323/47 ,  C07C323/20 ,  C07C323/16 ,  C07C321/28 ,  C07C317/44 ,  C07D213/75 ,  C07C317/22

CPC classification number: C07F9/4841 ,  C07C317/22 ,  C07C317/44 ,  C07C321/28 ,  C07C323/16 ,  C07C323/20 ,  C07C323/47 ,  C07C323/52 ,  C07C323/60 ,  C07C323/62 ,  C07D213/75 ,  C07F9/3229 ,  C07F9/5325

Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.

公开(公告)号：US09802906B1

公开(公告)日：2017-10-31

申请号：US15480565

申请日：2017-04-06

Applicant: ERREGIERRE S.p.A.

Inventor： Massimo Ferrari ,  Daniele De Zani ,  Matteo Bonaldi

IPC: C07D251/30 ,  C07C275/60 ,  C07C271/66

CPC classification number: C07D251/30 ,  C07C271/66 ,  C07C275/60 ,  C07C319/20 ,  C07C323/20

Abstract: Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N′-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III) wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.

公开(公告)号：US20170224682A1

公开(公告)日：2017-08-10

申请号：US15370973

申请日：2016-12-06

Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.

Inventor： Lloyd F. MACKENZIE ,  Thomas B. MACRURY ,  Curtis HARWIG ,  David BOGUCKI ,  Jeffery R. RAYMOND ,  Jeremy D. PETTIGREW ,  Vladimir KHLEBNIKOV ,  Rudong SHAN

IPC: A61K31/4965 ,  A61K31/122 ,  A61K31/135 ,  A61K31/085 ,  A61K31/05 ,  A61K31/192 ,  A61K31/09 ,  A61K31/167 ,  A61K31/165 ,  A61K31/277 ,  A61K31/095 ,  A61K31/166 ,  A61K31/4402 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/495 ,  A61K31/155 ,  A61K31/4406 ,  A61K31/4465 ,  A61K31/10 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/12

CPC classification number: A61K31/4965 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/095 ,  A61K31/10 ,  A61K31/12 ,  A61K31/122 ,  A61K31/135 ,  A61K31/155 ,  A61K31/165 ,  A61K31/166 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/496 ,  C07B2200/07 ,  C07C39/17 ,  C07C43/21 ,  C07C43/215 ,  C07C43/23 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07C62/32 ,  C07C62/34 ,  C07C217/84 ,  C07C225/20 ,  C07C233/26 ,  C07C233/28 ,  C07C233/31 ,  C07C233/32 ,  C07C233/60 ,  C07C233/76 ,  C07C235/82 ,  C07C237/08 ,  C07C255/47 ,  C07C275/26 ,  C07C275/64 ,  C07C279/16 ,  C07C311/07 ,  C07C311/17 ,  C07C311/18 ,  C07C317/22 ,  C07C323/20 ,  C07C2602/28 ,  C07D211/66 ,  C07D213/38 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D233/64 ,  C07D241/24 ,  C07D249/08 ,  C07D295/112 ,  C07D295/215 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

公开(公告)号：US20170050926A1

公开(公告)日：2017-02-23

申请号：US15187163

申请日：2016-06-20

Applicant: Northwestern University ,  The General Hospital Corporation

Inventor： Richard B. Silverman ,  Hua Wang ,  Mohammad Khanfar ,  Aleksey G. Kazantsev

IPC: C07C311/21 ,  C07D237/20 ,  C07C311/29 ,  C07D277/46 ,  C07D271/113 ,  C07D239/42 ,  C07D213/80 ,  C07D213/82 ,  C07D261/14 ,  C07D213/76 ,  C07D223/04 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  C07C317/44 ,  C07C317/48 ,  C07D213/75

CPC classification number: C07C311/21 ,  C07B2200/07 ,  C07C235/60 ,  C07C255/60 ,  C07C257/18 ,  C07C311/16 ,  C07C311/29 ,  C07C311/46 ,  C07C311/47 ,  C07C317/22 ,  C07C317/34 ,  C07C317/40 ,  C07C317/44 ,  C07C317/48 ,  C07C323/20 ,  C07C323/42 ,  C07C323/49 ,  C07C323/62 ,  C07C2601/02 ,  C07D207/16 ,  C07D213/75 ,  C07D213/76 ,  C07D213/80 ,  C07D213/81 ,  C07D213/82 ,  C07D213/85 ,  C07D217/04 ,  C07D223/04 ,  C07D237/20 ,  C07D239/42 ,  C07D261/14 ,  C07D271/113 ,  C07D277/46 ,  C07D295/26 ,  C07D305/06 ,  C07D311/16 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.

Abstract translation: 苯甲酰胺化合物及其衍生物，可用于选择性抑制SIRT2酶和/或用于治疗亨廷顿病的治疗用途。

公开(公告)号：US20160272906A1

公开(公告)日：2016-09-22

申请号：US14806389

申请日：2015-07-22

Applicant: Authentix, Inc.

Inventor： Jeffrey L. CONROY ,  Philip B. FORSHEE ,  John-Christopher BOYER

IPC: C10L1/24 ,  C10L10/00 ,  G01N21/65 ,  G01N33/22 ,  G01N24/08 ,  C10L1/185 ,  G01N30/72

CPC classification number: C10L1/2406 ,  C07B2200/05 ,  C07C43/2055 ,  C07C43/21 ,  C07C43/263 ,  C07C43/275 ,  C07C321/30 ,  C07C323/20 ,  C07C2601/14 ,  C07C2601/16 ,  C10L1/003 ,  C10L1/1608 ,  C10L1/1852 ,  C10L1/2412 ,  C10L10/00 ,  C10L2200/0263 ,  C10L2200/0446 ,  C10L2230/16 ,  G01N21/65 ,  G01N24/08 ,  G01N30/7206 ,  G01N33/22 ,  G01N2030/025

Abstract: A method of forming a composition comprising contacting a fuel and at least one compound of Formula I: wherein X is carbon, oxygen, or sulfur; R1 and R2 each independently are hydrogen, a C1 to C20 alkyl, or a C6 to C10 aryl; R3 and R3′ each independently are hydrogen or a C1 to C4 alkyl; R4 and R4′ each independently are hydrogen, a C1 to C4 alkyl, a C4 to C10 cycloalkyl, or a C6 to C10 aryl; R5 and R5′ each independently are a C4 to C10 alkyl; R6 and R6′ each independently are hydrogen or a C1 to C6 alkyl; and R7 and R7′ each independently are hydrogen or C1 to C4 alkyl; and wherein the compound of Formula I when subjected to GC-MS using electron ionization at greater than 70 eV produces at least one ion having a mass-to-charge ratio of 300 to 600.

Abstract translation: 其中X是碳，氧或硫; R 1和R 2各自独立地为氢，C 1至C 20烷基或C 6至C 10芳基; R 3和R 3'各自独立地为氢或C 1至C 4烷基; R 4和R 4'各自独立地为氢，C 1至C 4烷基，C 4至C 10环烷基或C 6至C 10芳基; R5和R5'各自独立地为C4至C10烷基; R6和R6'各自独立地为氢或C1至C6烷基; 并且R 7和R 7'各自独立地为氢或C 1至C 4烷基; 并且其中当使用大于70eV的电子电离进行GC-MS的式I化合物产生至少一种质荷比为300-600的离子。

公开(公告)号：US20150336876A1

公开(公告)日：2015-11-26

申请号：US14761897

申请日：2014-01-21

Applicant: OSAKA UNIVERSITY ,  KNC LABORATORIES CO., LTD.

Inventor： Yoshikatsu KANAI ,  Shushi NAGAMORI ,  Yoshihiko KITAURA ,  Masahiro NEYA ,  Naohiro MATSUSHITA

IPC: C07C217/48 ,  C07D333/20 ,  C07D277/28 ,  C07C217/72 ,  C07D215/233 ,  C07D213/68 ,  C07C255/54 ,  C07C255/37 ,  C07D215/26 ,  C07D209/48 ,  C07D401/12 ,  C07D409/06 ,  C07D405/06 ,  C07D417/06 ,  C07D413/06 ,  C07C271/16

CPC classification number: C07C217/48 ,  C07C211/09 ,  C07C217/04 ,  C07C217/72 ,  C07C255/37 ,  C07C255/54 ,  C07C271/16 ,  C07C271/20 ,  C07C317/22 ,  C07C317/28 ,  C07C323/20 ,  C07C323/25 ,  C07D209/48 ,  C07D213/68 ,  C07D215/22 ,  C07D215/233 ,  C07D215/26 ,  C07D263/32 ,  C07D277/28 ,  C07D295/08 ,  C07D307/52 ,  C07D333/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06

Abstract: The invention provides a compound having a selective inhibitory activity against highly-expressed LAT-1 in tumor cell. The compound is represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, and a LAT-1 inhibitor comprising the same.

Abstract translation: 本发明提供对肿瘤细胞中高表达LAT-1具有选择性抑制活性的化合物。 化合物由式（I）表示：其中每个符号如说明书中所定义，或其盐，和含有该化合物的LAT-1抑制剂。

公开(公告)号：US20150099883A1

公开(公告)日：2015-04-09

申请号：US14390849

申请日：2013-04-08

Applicant: NIPPON SODA CO., LTD.

Inventor： Hironori Furukawa ,  Daisuke Hanai ,  Tetsuo Tamai ,  Jun Kanazawa ,  Katsunori Tanaka ,  Asaho Nagagata

IPC: A01N47/28 ,  C07D417/12 ,  C07D213/70 ,  C07C275/64 ,  C07D277/64 ,  C07D417/14 ,  C07D239/38 ,  C07D239/42 ,  C07D513/04 ,  C07D413/12

CPC classification number: A01N47/28 ,  A01N47/34 ,  A61K9/107 ,  C07C275/64 ,  C07C317/20 ,  C07C317/32 ,  C07C321/28 ,  C07C323/20 ,  C07D213/70 ,  C07D239/38 ,  C07D239/42 ,  C07D277/62 ,  C07D277/64 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention provides an aryloxyurea compound or salt thereof, and a pest control agent including the aryloxyurea compound or salt thereof as an active ingredient. The aryloxyurea compound has a superior acaricidal and/or insecticidal activity, superior safety, and can be synthesized advantageously and industrially. The compound of the present invention includes aryloxyurea compounds represented by the following formula or salts thereof: in the formula, Cy represents an unsubstituted or X-substituted phenyl group or the like, X represents a halogen atom or the like, R1 represents an ethyl group or the like, R2 represents a hydrogen atom or the like, R3 and R4 represents a methyl group or the like, X1 represents a methylthio group or the like, m1 represents an integer of 1 to 4, X2 represents a methyl group or the like, m2 is an integer of 0 to 3.

Abstract translation: 本发明提供一种芳氧基脲化合物或其盐，和含有该芳氧基脲化合物或其盐作为有效成分的害虫防治剂。 芳氧基脲化合物具有优异的杀螨和/或杀虫活性，优异的安全性，并且可以有利地和工业上合成。 本发明的化合物包括由下式表示的芳氧基脲化合物或其盐：式中，Cy表示未取代或X取代的苯基等，X表示卤素原子等，R 1表示乙基 等等，R 2表示氢原子等，R 3和R 4表示甲基等，X 1表示甲硫基等，m 1表示1〜4的整数，X 2表示甲基等 ，m2为0〜3的整数。