公开(公告)号：US20110065711A1

公开(公告)日：2011-03-17

申请号：US12820570

申请日：2010-06-22

申请人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu

发明人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu

IPC分类号： A61K31/5025 ,  C07D487/04 ,  A61P25/00 ,  A61P29/00 ,  A61P19/02

CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K45/06

摘要： This invention relates to novel substituted triazolo-pyridazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an α1-GABAA receptor antagonist or an α2- and/or an α3-GABAA receptor partial agonist.

摘要翻译： 本发明涉及新的取代三唑并 - 哒嗪及其药学上可接受的盐。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过施用α1-GABA A受体拮抗剂或α2-和/或α3-GABA A受体部分激动剂有益治疗的疾病和病症的方法中的用途 。

公开(公告)号：US20110059995A1

公开(公告)日：2011-03-10

申请号：US12874049

申请日：2010-09-01

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  C07D473/04 ,  A61P3/10 ,  A61P1/16 ,  A61P13/12 ,  A61P27/02 ,  A61P31/18

CPC分类号： C07D473/04 ,  C07D473/06

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

公开(公告)号：US20100221221A1

公开(公告)日：2010-09-02

申请号：US12539091

申请日：2009-08-11

申请人： Scott L. Harbeson ,  Julie F. Liu ,  Roger Tung

发明人： Scott L. Harbeson ,  Julie F. Liu ,  Roger Tung

IPC分类号： A61K38/21 ,  C07D401/14 ,  A61K31/506 ,  A61P35/02 ,  A61P35/00 ,  A61P33/06 ,  A61P35/04 ,  A61P27/14 ,  A61P19/02 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P3/10 ,  A61P9/10 ,  A61P17/10 ,  A61P31/12 ,  A61P13/06 ,  A61P31/18 ,  A61K39/395 ,  C12N5/02 ,  A61K31/55 ,  A61K38/50 ,  A61K31/661 ,  A61K31/7068 ,  A61K35/12 ,  A61K33/24

CPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07D401/04 ,  C07F9/65583

摘要： This disclosure relates to novel N-phenyl-2-pyrimidineamines and pharmaceutically acceptable salts thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering protein-tyrosine kinase inhibitors.

摘要翻译： 本公开涉及新的N-苯基-2-嘧啶胺及其药学上可接受的盐。 本公开还提供了包含本公开的化合物的组合物以及这些组合物在治疗通过施用蛋白质 - 酪氨酸激酶抑制剂有益治疗的疾病和病症的方法中的用途。

公开(公告)号：US20090270336A1

公开(公告)日：2009-10-29

申请号：US12386492

申请日：2009-04-17

申请人： Julie F. Liu ,  Rose Persichetti

发明人： Julie F. Liu ,  Rose Persichetti

IPC分类号： A61K31/505 ,  C07D401/14 ,  A61K31/497 ,  C12N5/02

CPC分类号： C07D401/14

摘要： This invention relates to novel compounds that are piperazine derivatives, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel piperazine compounds that are derivatives of the chemokine CCR5 receptor antagonist, vicriviroc. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering chemokine CCR5 receptor antagonists, such as vicriviroc. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving vicriviroc.

摘要翻译： 本发明涉及作为哌嗪衍生物的新化合物及其药学上可接受的盐。 更具体地，本发明涉及作为趋化因子CCR5受体拮抗剂vicriviroc的衍生物的新型哌嗪化合物。 本发明还提供了不含热原的组合物，其包含一种或多种本发明化合物和载体，以及所公开的化合物和组合物在治疗通过施用趋化因子CCR5受体拮抗剂例如维利维罗治疗的疾病和病症的方法中的用途。 本发明还涉及一种或多种所公开的化合物在涉及vicriviroc的分析研究中作为试剂的用途。

公开(公告)号：US07608737B2

公开(公告)日：2009-10-27

申请号：US12112722

申请日：2008-04-30

申请人： Julie F. Liu ,  Roger Tung

发明人： Julie F. Liu ,  Roger Tung

IPC分类号： C07C233/05 ,  A61K31/16

CPC分类号： C07C233/18 ,  C07B2200/05 ,  C07C233/22

摘要： This disclosure relates to novel melatonin analogues or naphthyl(ethyl)acetamides, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a dual melatoninergic agonist and serotoninergic antagonist.

摘要翻译： 本公开涉及新颖的褪黑素类似物或萘基（乙基）乙酰胺，其衍生物，药学上可接受的盐，溶剂化物和其水合物。 本公开还提供了包含本公开的化合物和这种组合物在治疗通过施用双褪黑素激动剂和5-羟色胺能拮抗剂有益治疗的疾病和病症的方法中的用途的组合物。

公开(公告)号：US20090239886A1

公开(公告)日：2009-09-24

申请号：US12380579

申请日：2009-02-27

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  C07D473/04 ,  A61P13/12

CPC分类号： C07D473/10 ,  C07B2200/05 ,  C07B2200/07 ,  C07D473/04

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

摘要翻译： 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如，本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。

公开(公告)号：US20090143363A1

公开(公告)日：2009-06-04

申请号：US12288013

申请日：2008-10-15

申请人： Julie F. Liu

发明人： Julie F. Liu

IPC分类号： A61K31/55 ,  C07D223/16 ,  A61P25/00

CPC分类号： C07D223/16

摘要： This invention relates to novel compounds that are 3-benzazepine derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel 3-benzazepine derivatives that are derivatives of lorcaserin. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering a 5-HT2C agonist, such as lorcaserin.

摘要翻译： 本发明涉及作为3-苯并氮杂衍生物的新化合物及其药学上可接受的盐。 更具体地，本发明涉及作为氯卡色林的衍生物的新的3-苯并氮杂衍生物。 本发明还提供包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗通过施用5-HT 2C激动剂如氯卡色林有益治疗的疾病和病症的方法中的用途。

公开(公告)号：US08410082B2

公开(公告)日：2013-04-02

申请号：US13320646

申请日：2010-05-20

申请人： Julie F. Liu ,  Roger D. Tung ,  Scott L. Harbeson

发明人： Julie F. Liu ,  Roger D. Tung ,  Scott L. Harbeson

IPC分类号： A61K31/56 ,  A61K31/44 ,  A61K38/21 ,  A61K39/00 ,  A61K33/24 ,  C07D213/78

CPC分类号： C07D213/81 ,  C07B59/002

摘要： This invention relates to novel diaryl urea compounds, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of multiple kinases.

摘要翻译： 本发明涉及新的二芳基脲化合物，其衍生物及其药学上可接受的盐。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过施用多种激酶抑制剂有益治疗的疾病和病症的方法中的用途。

公开(公告)号：US08357674B2

公开(公告)日：2013-01-22

申请号：US13538952

申请日：2012-06-29

申请人： Julie F. Liu ,  Rose A. Persichetti

发明人： Julie F. Liu ,  Rose A. Persichetti

IPC分类号： A61K31/4709 ,  A61K31/616 ,  A61P3/10 ,  A61P9/00 ,  A61P3/04 ,  A61P7/02 ,  A61P1/04 ,  A61P11/06 ,  A61P15/00 ,  A61P9/10 ,  C07D401/12

CPC分类号： C07D401/12

摘要： This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of an phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.

公开(公告)号：US20120264721A1

公开(公告)日：2012-10-18

申请号：US13538952

申请日：2012-06-29

申请人： Julie F. Liu ,  Rose A. Persichetti

发明人： Julie F. Liu ,  Rose A. Persichetti

IPC分类号： A61K31/4709 ,  A61K31/616 ,  A61P3/10 ,  A61P9/00 ,  A61P3/04 ,  A61P7/02 ,  A61P1/04 ,  A61P11/06 ,  A61P15/00 ,  C07D401/12 ,  A61P9/10

CPC分类号： C07D401/12

摘要： This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of an phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.

摘要翻译： 本发明涉及作为磷酸二酯酶抑制剂西洛他唑及其药学上可接受的盐的衍生物的新化合物。 本发明还提供了包含一种或多种本发明化合物的无热原组合物，以及所公开的化合物和组合物在治疗通过施用磷酸二酯酶抑制剂如西洛他唑治疗的疾病和病症的方法中的用途。 本发明还涉及所公开的化合物和组合物在涉及西洛他唑的分析研究中作为试剂的用途。