公开(公告)号：US07455646B2

公开(公告)日：2008-11-25

申请号：US11768794

申请日：2007-06-26

Applicant: Mark T. Richardson ,  David M. Anderson ,  Emmanuel C. Biagtan ,  Lawrence E. Brennan ,  David H. Burkett ,  Wayne E. Cornish ,  Robert C. Esselstein ,  James Jacobs ,  Marc M. Jalisi ,  Daryush P. Mirzaee ,  Olin J. Palmer ,  John Schreiner ,  Kent C. Stalker

Inventor： Mark T. Richardson ,  David M. Anderson ,  Emmanuel C. Biagtan ,  Lawrence E. Brennan ,  David H. Burkett ,  Wayne E. Cornish ,  Robert C. Esselstein ,  James Jacobs ,  Marc M. Jalisi ,  Daryush P. Mirzaee ,  Olin J. Palmer ,  John Schreiner ,  Kent C. Stalker

IPC: A61B5/00 ,  A61M25/00

CPC classification number: A61M25/09 ,  A61L31/10 ,  A61L31/18 ,  A61M25/0045 ,  A61M25/0054 ,  A61M2025/09083 ,  A61M2025/09133 ,  A61M2025/09166

Abstract: A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.

Abstract translation: 具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。 该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。 一个实施例具有多个不透射线的元件，其可以是间歇的，连续的或以螺旋带的形式，用于在荧光成像下对体内结构进行缩放测量。 另一个实施方案在装置的远端上具有至少一层聚合物。

公开(公告)号：US06524301B1

公开(公告)日：2003-02-25

申请号：US09748294

申请日：2000-12-21

Applicant: W. Stan Wilson ,  Robert C. Esselstein ,  Wayne E. Cornish ,  Mark T. Richardson

Inventor： W. Stan Wilson ,  Robert C. Esselstein ,  Wayne E. Cornish ,  Mark T. Richardson

IPC: A61M2500

CPC classification number: A61M25/09 ,  A61M2025/09083 ,  A61M2025/09133

Abstract: The invention is directed to an guide wire for intraluminal deployment of a medical device within a patient, the guide wire having an elongate core member with an intermediate core section comprising a plurality of contiguous segments in alignment with the longitudinal axis of the core member with alternating flexible and rigid core segments, so that the articulated section bends in a discontinuous, discrete manner when advanced through a curved blood vessel or other body lumen within the patient. When an obstruction on a vessel wall causes the catheter or other coaxial device to be impeded, the guide wire and intermediate core section may alternately be advanced and retracted a short distance through the catheter distal tip causing a “nodding” motion of the catheter tip while the catheter is pushed through the vessel, so as to avoid and bypass the vessel obstruction.

Abstract translation: 本发明涉及一种用于在患者体内腔内部署医疗装置的导丝，所述导丝具有细长的芯部件，所述细长的芯部件具有中间的芯部分，所述中间纤芯部分包括与所述芯部件的纵向轴线对准的多个连续部分， 柔性和刚性的芯段，使得铰接部分在通过患者体内的弯曲血管或其他体腔前进时以不连续的离散方式弯曲。 当血管壁上的阻塞物导致导管或其它同轴装置被阻碍时，引导线和中间芯部分可以交替地前进并缩回穿过导管远端的短距离，导致导管末端的“点头”运动，同时 导管被推过血管，以避免和绕过血管阻塞。

公开(公告)号：US06352515B1

公开(公告)日：2002-03-05

申请号：US09459814

申请日：1999-12-13

Applicant: David M. Anderson ,  Wayne E. Cornish ,  Marc Mehrzad Jalisi ,  Nancy Nicotra ,  Mark T. Richardson

Inventor： David M. Anderson ,  Wayne E. Cornish ,  Marc Mehrzad Jalisi ,  Nancy Nicotra ,  Mark T. Richardson

IPC: A61B500

CPC classification number: A61M25/09 ,  A61M2025/09083 ,  A61M2025/09133 ,  A61M2025/09141

Abstract: The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the same. The device, has proximal and distal ends and includes an elongated high strength proximal portion having proximal and distal ends. The device further includes a distal portion having proximal and distal ends. The distal end of the proximal portion and the proximal end of the distal portion are connected by a connector. The distal portion is formed of a superelastic alloy composition. Preferably, the connector is also formed of the superelastic alloy composition. The superelastic alloy composition includes, in atomic percent, from about 28 to about 52% nickel, from about 48 to about 52% titanium, and up to about 20% of at least one alloying element selected from the group consisting of palladium, chromium, and hafnium.

Abstract translation: 本发明涉及一种体内装置，优选导丝及其制造方法。 该装置具有近端和远端并且包括具有近端和远端的细长的高强度近端部分。 该装置还包括具有近端和远端的远侧部分。 近端部分的远端和远端部分的近端通过连接器连接。 远端部分由超弹性合金组成形成。 优选地，连接器也由超弹性合金组合物形成。 超弹性合金组成包括原子百分比为约28至约52％的镍，约48至约52％的钛，以及至多一种选自钯，铬， 和铪。

公开(公告)号：US08308660B2

公开(公告)日：2012-11-13

申请号：US13150973

申请日：2011-06-01

Applicant: Wayne E. Cornish ,  John F. Schreiner ,  James M. Jacobs ,  Marc M. Jalisi ,  Mark T. Richardson ,  Kent C. B. Stalker ,  Olin J. Palmer

Inventor： Wayne E. Cornish ,  John F. Schreiner ,  James M. Jacobs ,  Marc M. Jalisi ,  Mark T. Richardson ,  Kent C. B. Stalker ,  Olin J. Palmer

IPC: A61B5/00

CPC classification number: A61B5/6851 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09175

Abstract: The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device.

Abstract translation: 本发明涉及一种具有多个具有至少两个相邻的远端锥形芯段的多个远端锥形芯部段的远端部分，其中最远端锥形芯部段优选地具有比近端相邻的锥形芯部分更大的锥度。 本发明还涉及一种细长的体内装置，优选的导丝或其一部分，其具有芯构件或类似物，多个相邻的锥形段具有锥形角，该锥形角构造成在纵向截面上产生刚度线性变化 的设备。 该装置还可以具有连续变化的锥角的芯部分，以产生曲线轮廓，该曲线轮廓优选地被配置为在装置的纵向部分上产生芯的刚度的线性变化。

公开(公告)号：US07972283B2

公开(公告)日：2011-07-05

申请号：US12047008

申请日：2008-03-12

Applicant: Wayne E. Cornish ,  John F. Schreiner ,  James M. Jacobs ,  Marc M. Jalisi ,  Mark T. Richardson ,  Kent C. B. Stalker ,  Olin J. Palmer

Inventor： Wayne E. Cornish ,  John F. Schreiner ,  James M. Jacobs ,  Marc M. Jalisi ,  Mark T. Richardson ,  Kent C. B. Stalker ,  Olin J. Palmer

IPC: A61B5/00

CPC classification number: A61B5/6851 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09175

Abstract: The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device.

Abstract translation: 本发明涉及一种具有多个具有至少两个相邻的远端锥形芯段的多个远端锥形芯部段的远端部分，其中最远端锥形芯部段优选地具有比近端相邻的锥形芯部分更大的锥度。 本发明还涉及一种细长的体内装置，优选的导丝或其一部分，其具有芯构件或类似物，多个相邻的锥形段具有锥形角，该锥形角构造成在纵向截面上产生刚度线性变化 的设备。 该装置还可以具有连续变化的锥角的芯部分，以产生曲线轮廓，该轮廓优选被配置成在装置的纵向部分上产生芯的刚度的线性变化。

公开(公告)号：US20100004562A1

公开(公告)日：2010-01-07

申请号：US12554178

申请日：2009-09-04

Applicant: Marc M. Jalisi ,  David M. Anderson ,  Wayne E. Cornish ,  Nancy A. Nicotra ,  Mark T. Richardson

Inventor： Marc M. Jalisi ,  David M. Anderson ,  Wayne E. Cornish ,  Nancy A. Nicotra ,  Mark T. Richardson

IPC: A61M25/09

CPC classification number: A61M25/09 ,  A61M2025/09175

Abstract: The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the device. The guidewire of the present invention is formed, at least in part, of a composite elongate core formed, at least in part, of precipitation hardened material. The elongate core members of the present invention will have an ultimate tensile strength and modulus of elasticity greater than the same for an identically dimensioned elongate member formed from superelastic NITINOL alone.

Abstract translation: 本发明涉及体内装置，优选导丝，以及制造该装置的方法。 本发明的导丝至少部分地形成有至少部分由沉淀硬化材料形成的复合细长芯。 对于由超弹性NITINOL单独形成的相同尺寸的细长构件，本发明的细长芯构件将具有大于相同尺寸的极限拉伸强度和弹性模量。