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21.发明授权Process for preparing piroxicam/cyclodextrin complexes, the products obtained and their pharmaceutical compositions 失效制备吡罗昔康/环糊精复合物的方法，获得的产品及其药物组合物
公开(公告)号：US5164380A
公开(公告)日：1992-11-17
申请号：US676070
申请日：1991-03-27
申请人： Fabio Carli , Paolo Chiesi
发明人： Fabio Carli , Paolo Chiesi
IPC分类号： A61K9/20 , A61K9/14 , A61K9/18 , A61K31/54 , A61K31/5415 , A61K31/724 , A61K47/40 , A61K47/48 , A61P25/04 , A61P29/00
CPC分类号： B82Y5/00 , A61K31/54 , A61K47/48969 , Y10S514/964 , Y10S514/965
摘要： A process for preparing complexes of piroxicam with cyclodextrins in which the two components in the powder state are premixed and then co-ground in a high energy mill in the presence of steam.The products obtained have technological, physical and biopharmacological characteristics which are advantageous compared with those of liquid-state complexes obtained by traditional methods, and are suitable for preparing pharmaceutical compositions for oral, rectal and topical use.
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公开(公告)号：US5017607A
公开(公告)日：1991-05-21
申请号：US374273
申请日：1989-06-30
申请人： Paolo Chiesi
发明人： Paolo Chiesi
IPC分类号： A61K31/215 , A61K9/08 , A61K9/20 , A61K31/135 , A61K31/165 , A61K31/195 , A61K31/198 , A61P25/00
CPC分类号： A61K31/195
摘要： Pharmaceutical compositions for the treatment of Parkinson's disease and neurologic syndromes connected with it, containing as the active principle levodopa methyl ester optionally combined with other active principles selected from dopaminergic, anticholinergic, antidepressive drugs, carboxylase and monoaminoxidase inhibitors.
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23.发明授权1,4:3,6-dianhydrosorbitol 2-mononitrate and 5-mononitrate esters and pharmaceutical compositions therefrom 失效1,4：3,6-二氢山梨醇2-一硝酸酯和5-一硝酸酯及其药物组合物
公开(公告)号：US4956384A
公开(公告)日：1990-09-11
申请号：US189982
申请日：1988-05-04
申请人： Paolo Chiesi , Vittorino Servadio
发明人： Paolo Chiesi , Vittorino Servadio
IPC分类号： A61K31/34 , A61P9/00 , C07D493/04
CPC分类号： C07D493/04
摘要： Isosorbide 2- and 5-mononitrate esters with aliphatic, aryl, or cynnamic acids or diacids, or with alkylcarbonyloxy substituents optionally containing an isosorbide 2- or 5-mononitrate group, are useful in human therapy.
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公开(公告)号：US07132115B2
公开(公告)日：2006-11-07
申请号：US10628453
申请日：2003-07-29
申请人： Rossella Musa , Roberto Bilzi , Paolo Ventura , Paolo Chiesi
发明人： Rossella Musa , Roberto Bilzi , Paolo Ventura , Paolo Chiesi
CPC分类号： A61K9/0075 , A61K9/145
摘要： The invention relates to carrier particles for use in pharmaceutical compositions for the pulmonary administration of medicaments by means of dry powder inhalers. In particular, the invention relates to a novel technological process for obtaining a carrier modified so as to improve the efficiency of redispersion of active particles and hence increase the respirable fraction. After the treatment of the invention, the surface of said modified carrier particles can also be coated with a suitable additive so as to further improve the respirable fraction.
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公开(公告)号：US06953813B1
公开(公告)日：2005-10-11
申请号：US10030114
申请日：2000-07-26
申请人： Stefano Bongrani , Roberta Razzetti , Paolo Chiesi
发明人： Stefano Bongrani , Roberta Razzetti , Paolo Chiesi
IPC分类号： A61K31/222 , A61P27/06 , A01N37/06 , C07C69/00
CPC分类号： A61K31/222
摘要： The use of racemic or optically active compounds represented by formula (I) and the salts thereof wherein R is H or CH3 for the preparation of pharmaceutical compositions for the therapy of ophthalmic disorders.
摘要翻译： 使用由式（I）表示的外消旋或光学活性化合物及其盐，其中R是用于制备用于治疗眼科疾病的药物组合物的H或CH 3。
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公开(公告)号：US06667056B2
公开(公告)日：2003-12-23
申请号：US09932097
申请日：2001-08-20
IPC分类号： A61K946
CPC分类号： A61K9/0007
摘要： A pharmaceutical formulation in the form of a fast dissolving tablet comprising an active ingredient, sodium glycine carbonate and an acid capable of reacting rapidly with sodium glycine carbonate to release carbon dioxide.
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公开(公告)号：US06284272B1
公开(公告)日：2001-09-04
申请号：US09463224
申请日：2000-03-21
IPC分类号： A61K946
CPC分类号： A61K9/0007
摘要： A pharmaceutical composition in the form of effervescent tablets comprising an active ingredient and an effervescent blend, wherein the effervescent blend comprises an acidic component and sodium glycine carbonate as alkaline components. Preferred acid components are fumaric acid, maleic acid, and their salts. Tablets are prepared in normal thermo-hygrometric conditions and with standard tabletting equipment.
摘要翻译： 泡腾片剂形式的药物组合物，其包含活性成分和泡腾混合物，其中所述泡腾混合物包含作为碱性组分的酸性组分和甘氨酸钠。 优选的酸组分是富马酸，马来酸及其盐。 在正常的热湿度条件和标准压片设备中制备片剂。
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公开(公告)号：US6103760A
公开(公告)日：2000-08-15
申请号：US328434
申请日：1999-06-09
IPC分类号： A61K31/135 , A61K31/136 , A61K31/221 , A61K31/222 , A61K38/55 , A61P9/00 , A61P9/04 , A61P9/10 , A61K31/21
CPC分类号： A61K31/222 , A61K31/135 , A61K31/136 , A61K31/221 , A61K38/556
摘要： Left ventricular dysfunction is treated by a process, comprising:administering to a subject suffering from left ventricular remodeling a therapeutically effective amount of 5,6-dihydroxy-2-methylaminotetralin, or 5,6-diisobutyroyl-oxy-2-methyl-aminotetralin, or a pharmaceutically acceptable salt thereof in combination with an angiotensin-converting enzyme inhibitor.
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29.发明授权
公开(公告)号：US5504105A
公开(公告)日：1996-04-02
申请号：US177798
申请日：1994-01-06
申请人： Paolo Chiesi , Luciana Pavesi
发明人： Paolo Chiesi , Luciana Pavesi
CPC分类号： A61K9/4858 , A61K31/35 , A61K47/44
摘要： Oral pharmaceutical compositions containing Ipriflavone comprising oily vehicles that promote absorption of the drug enabling the dosage to be simplified.
摘要翻译： 含有伊曲黄酮的口服药物组合物，其包含促进药物吸收的油性载体，使得能够简化剂量。
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公开(公告)号：US20120017896A1
公开(公告)日：2012-01-26
申请号：US13252532
申请日：2011-10-04
申请人： Egbert HERTING , Wolfgang Gopel , Paolo Chiesi
发明人： Egbert HERTING , Wolfgang Gopel , Paolo Chiesi
CPC分类号： A61K9/0082 , A61K38/395
摘要： The present invention concerns a method for treating a respiratory distress in a infant in need of such treatment, the method comprising intratracheal administration of a pulmonary surfactant by a thin tube.The invention also concerns a kit for performing said method.
摘要翻译： 本发明涉及一种治疗需要这种治疗的婴儿的呼吸窘迫的方法，该方法包括通过细管气管内给予肺表面活性剂。 本发明还涉及用于执行所述方法的套件。
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