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公开(公告)号：US20120031403A1
公开(公告)日：2012-02-09
申请号：US13195885
申请日：2011-08-02
Applicant: Daniela COCCONI , Francesca Schiaretti , Roberto Bilzi
Inventor： Daniela COCCONI , Francesca Schiaretti , Roberto Bilzi
CPC classification number: A61K31/44 , A61K9/0075 , A61K9/145
Abstract: Pharmaceutical formulations in the form of inhalable dry powder comprising particles of a phosphodiesterase-4 inhibitor as active ingredient are useful for the prevention and/or treatment of respiratory diseases, such as asthma and COPD.
Abstract translation: 以含有磷酸二酯酶-4抑制剂颗粒的可吸入干粉形式的药物制剂作为活性成分可用于预防和/或治疗呼吸系统疾病如哮喘和COPD。
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Patent Agency Ranking
公开(公告)号：US09132121B2
公开(公告)日：2015-09-15
申请号：US13195885
申请日：2011-08-02
Applicant: Daniela Cocconi , Francesca Schiaretti , Roberto Bilzi
Inventor： Daniela Cocconi , Francesca Schiaretti , Roberto Bilzi
CPC classification number: A61K31/44 , A61K9/0075 , A61K9/145
Abstract: Pharmaceutical formulations in the form of inhalable dry powder comprising particles of a phosphodiesterase-4 inhibitor as active ingredient are useful for the prevention and/or treatment of respiratory diseases, such as asthma and COPD.
Abstract translation: 以含有磷酸二酯酶-4抑制剂颗粒的可吸入干粉形式的药物制剂作为活性成分可用于预防和/或治疗呼吸系统疾病如哮喘和COPD。
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公开(公告)号：US07132115B2
公开(公告)日：2006-11-07
申请号：US10628453
申请日：2003-07-29
Applicant: Rossella Musa , Roberto Bilzi , Paolo Ventura , Paolo Chiesi
Inventor： Rossella Musa , Roberto Bilzi , Paolo Ventura , Paolo Chiesi
CPC classification number: A61K9/0075 , A61K9/145
Abstract: The invention relates to carrier particles for use in pharmaceutical compositions for the pulmonary administration of medicaments by means of dry powder inhalers. In particular, the invention relates to a novel technological process for obtaining a carrier modified so as to improve the efficiency of redispersion of active particles and hence increase the respirable fraction. After the treatment of the invention, the surface of said modified carrier particles can also be coated with a suitable additive so as to further improve the respirable fraction.
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公开(公告)号：US06641844B1
公开(公告)日：2003-11-04
申请号：US09926105
申请日：2001-09-27
Applicant: Rossella Musa , Roberto Bilzi , Paolo Ventura , Paolo Chiesi
Inventor： Rossella Musa , Roberto Bilzi , Paolo Ventura , Paolo Chiesi
IPC: A61K900
CPC classification number: A61K9/0075 , A61K9/145
Abstract: The invention relates to carrier particles for use in pharmaceutical compositions for the pulmonary administration of medicaments by means of dry powder inhalers. In particular, the invention relates to a novel technological process for obtaining a carrier modified so as to improve the efficiency of redispersion of active particles and hence increase the respirable fraction. After the treatment of the invention, the surface of said modified carrier particles can also be coated with a suitable additive so as to further improve the respirable fraction.
Abstract translation: 本发明涉及用于通过干粉吸入器肺部给予药物的药物组合物中的载体颗粒。 特别地，本发明涉及一种获得改性的载体以提高活性颗粒再分散效率并从而增加可呼吸分数的新技术方法。 在本发明的处理之后，所述改性载体颗粒的表面也可以涂覆合适的添加剂，以进一步改善可呼吸部分。
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5.发明授权Pharmaceutical formulations for dry powder inhalers comprising a low-dosage strength active ingredient 有权用于干粉吸入器的药物制剂，其包含低剂量强度的活性成分公开(公告)号：US08153104B2
公开(公告)日：2012-04-10
申请号：US10592701
申请日：2005-03-16
Applicant: Roberto Bilzi , Angela Armanni , Roberto Rastelli , Daniela Cocconi , Rosella Musa
Inventor： Roberto Bilzi , Angela Armanni , Roberto Rastelli , Daniela Cocconi , Rosella Musa
CPC classification number: A61K9/0075 , A61K9/5015 , A61K9/5084 , A61K31/4704
Abstract: The invention provides a formulation to be administered as dry powder for inhalation suitable for efficacious delivery of low-dosage strength active ingredients to the low respiratory tract of patient. In particular, the invention provides a formulation comprising microparticles constituted of microparticles of a low-dosage strength active ingredient and microparticles of an excipient wherein the MMD of the microparticles is comprised between 2 and 15 micron, at least 10% of the microparticles has a mass diameter (MD) higher than 0.5 micron, and the process of preparation thereof.
Abstract translation: 本发明提供了作为吸入干燥粉末施用的制剂，其适合于向患者的低呼吸道有效递送低剂量强度的活性成分。 特别地，本发明提供了一种制剂，其包含由低剂量强度活性成分的微粒和赋形剂微粒构成的微粒，其中微粒的MMD为2至15微米，至少10％的微粒具有质量 直径（MD）高于0.5微米，及其制备方法。
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6.发明申请Pharmaceutical Formulations For Dry Powder Inhalers Comprising A Low-Dosage Strength Active Ingredient 有权用于含有低剂量强度活性成分的干粉吸入器的药物制剂公开(公告)号：US20070202053A1
公开(公告)日：2007-08-30
申请号：US10592701
申请日：2005-03-16
Applicant: Roberto Bilzi , Angela Armanni , Roberto Rastelli , Daniela Cocconi , Rosella Musa
Inventor： Roberto Bilzi , Angela Armanni , Roberto Rastelli , Daniela Cocconi , Rosella Musa
IPC: A61K31/58 , A61K31/4745 , A61K9/14
CPC classification number: A61K9/0075 , A61K9/5015 , A61K9/5084 , A61K31/4704
Abstract: The invention provides a formulation to be administered as dry powder for inhalation suitable for efficacious delivery of low-dosage strength active ingredients to the low respiratory tract of patient. In particular, the invention provides a formulation comprising microparticles constituted of microparticles of a low-dosage strength active ingredient and microparticles of an excipient wherein the MMD of the microparticles is comprised between 2 and 15 micron, at least 10% of the microparticles has a mass diameter (MD) higher than 0.5 micron, and the process of preparation thereof.
Abstract translation: 本发明提供了作为吸入干燥粉末施用的制剂，其适合于向患者的低呼吸道有效递送低剂量强度的活性成分。 特别地，本发明提供了一种制剂，其包含由低剂量强度活性成分的微粒和赋形剂微粒构成的微粒，其中微粒的MMD为2至15微米，至少10％的微粒具有质量 直径（MD）高于0.5微米，及其制备方法。
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