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    Cyclodextrin nanotechnology for ophthalmic drug delivery
    5.
    发明授权
    Cyclodextrin nanotechnology for ophthalmic drug delivery 有权
    环糊精纳米技术用于眼科药物递送

    公开(公告)号：US08633172B2

    公开(公告)日：2014-01-21

    申请号：US13758955

    申请日：2013-02-04

    申请人： Thorsteinn Loftsson ,  Einar Stefansson

    发明人： Thorsteinn Loftsson ,  Einar Stefansson

    IPC分类号： A61K31/724 ,  A61K31/715

    CPC分类号： A61K47/48969 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/10 ,  A61K31/404 ,  A61K31/42 ,  A61K31/5377 ,  A61K31/5513 ,  A61K31/565 ,  A61K31/573 ,  A61K31/58 ,  A61K38/13 ,  A61K47/6905 ,  A61K47/6951 ,  B82Y5/00 ,  Y10S514/914

    摘要： The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about 90% (w/v) of the drug in solution, as dissolved free drug and as dissolved drug/cyclodextrin complex(es), and a solid phase of from about 10% (w/v) to about 99.9% (w/v) of the drug as solid drug/cyclodextrin particles, suspended in the aqueous phase; the size of the solid particles being from about 10 nm to about 1 mm, the drug/cyclodextrin particles being capable of dissolving in aqueous tear fluid within 24 hours of application to the eye surface. The aqueous eye suspension can be in the form of eye drops, eye gel or eye mist. Further, the invention provides a method for treating a condition of the posterior segment and/or anterior segment of the eye comprising applying to the eye surface, in an amount which delivers to said segment or segments a therapeutically effective amount of a drug suitable for treating said condition, an ophthalmic composition which is as defined above. Nasal compositions and methods and ophthalmic and nasal compositions in powder form are also provided.

    摘要翻译： 本发明提供了一种眼用组合物，其为包含药物，环糊精和水的水性悬浮液，所述组合物的水相为溶液中约0.1％（w / v）至约90％（w / v） 溶解的药物和溶解的药物/环糊精复合物，以及作为固体药物/环糊精颗粒的约10％（w / v）至约99.9％（w / v）的药物的固相，悬浮于 水相; 固体颗粒的尺寸为约10nm至约1mm，药物/环糊精颗粒能够在施用于眼表面后24小时内溶解于水性泪液中。 水性眼睛悬浮液可以是滴眼液，眼凝胶或眼睛雾沫的形式。 此外，本发明提供了一种用于治疗眼部后段和/或前段的病症的方法，包括向眼表面施用一定量的量，其量递送至所述片段或分段治疗有效量的适于治疗的药物 所述病症，如上所述的眼用组合物。 还提供鼻组合物和方法以及粉末形式的眼和鼻组合物。