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21.Method for synthesis of perindopril and its pharmaceutically acceptable salts 有权
标题翻译: 培哚普利及其药学上可接受的盐的合成方法公开(公告)号:US06835843B2
公开(公告)日:2004-12-28
申请号:US10239129
申请日:2002-09-19
申请人: Pascal Langlois , Hugues Turbe
发明人: Pascal Langlois , Hugues Turbe
IPC分类号: C07D20942
CPC分类号: C07K5/06026 , A61K38/00 , C07D209/42
摘要: The invention concerns a method for synthesis of perindopril of formula (I) and its pharmaceutically acceptable salts
摘要翻译: 本发明涉及式(I)培哚普利及其药学上可接受的盐的合成方法
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22.
公开(公告)号:US07358372B2
公开(公告)日:2008-04-15
申请号:US10566562
申请日:2004-07-29
申请人: Claude Fugier , Thierry Dubuffet , Pascal Langlois
发明人: Claude Fugier , Thierry Dubuffet , Pascal Langlois
IPC分类号: C07D209/02
CPC分类号: C07K5/06026 , A61K38/00 , C07D209/42
摘要: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
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23.Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates 有权
标题翻译: 5-氨基-3-羧甲基-4-氰基-2-噻吩羧酸的甲基二酯的工业合成方法,应用于雷奈酸二价盐及其水合物的合成公开(公告)号:US07238815B2
公开(公告)日:2007-07-03
申请号:US11358496
申请日:2006-02-21
IPC分类号: C07D333/42
CPC分类号: C07C255/23 , C07D333/38
摘要: Process for the industrial synthesis of the compound of formula (I): Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.
摘要翻译: 用于工业合成式(I)化合物的方法:用于合成雷奈酸二价盐,更特别是雷奈酸锶及其水合物。
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24.Method for synthesising perindopril and the pharmaceutically acceptable salt thereof 有权
标题翻译: 合成培哚普利及其药学上可接受的盐的方法公开(公告)号:US07166633B2
公开(公告)日:2007-01-23
申请号:US10547131
申请日:2004-02-27
申请人: Thierry Dubuffet , Pascal Langlois
发明人: Thierry Dubuffet , Pascal Langlois
IPC分类号: A61K31/403 , C07D209/12
CPC分类号: C07K5/0222 , C07D209/42 , C07K5/06026 , C07K5/06139 , Y02P20/55
摘要: Process for the synthesis of perindopril of formula (I): and pharmaceutically acceptable salts thereof.
摘要翻译: 用于合成式(I)培哚普利的方法及其药学上可接受的盐。
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25.Method for synthesizing derivatives of (2S,3AS,7AS)-1-[(S)-alanyl]-octahydro,-1H-indole-2-carboxylic acid and the use thereof for perindopril synthesis 有权
标题翻译: 合成(2S,3AS,7AS)-1 - [(S) - 丙氨酰] - 八氢-1H-吲哚-2-羧酸的衍生物的方法及其用于培哚普利合成公开(公告)号:US07157485B2
公开(公告)日:2007-01-02
申请号:US10547132
申请日:2004-02-27
申请人: Thierry Dubuffet , Pascal Langlois
发明人: Thierry Dubuffet , Pascal Langlois
IPC分类号: A61K31/403 , C07D209/12
CPC分类号: C07K5/0222 , C07D209/42 , C07K5/06026 , Y02P20/55
摘要: Process for the synthesis of compounds of formula (I): wherein R1 represents hydrogen, alkyl or benzyl and R2 represents a protecting group for the amine function. Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.
摘要翻译: 用于合成式(I)化合物的方法:其中R 1表示氢,烷基或苄基,R 2代表胺官能团的保护基。 在培哚普利及其药学上可接受的盐的合成中的应用。
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26.Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof 有权
标题翻译: 用于合成培哚普利的新方法及其药学上可接受的盐公开(公告)号:US20060183920A1
公开(公告)日:2006-08-17
申请号:US10566562
申请日:2004-07-29
申请人: Claude Fugier , Thierry Dubuffet , Pascal Langlois
发明人: Claude Fugier , Thierry Dubuffet , Pascal Langlois
IPC分类号: C07D209/42
CPC分类号: C07K5/06026 , A61K38/00 , C07D209/42
摘要: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
摘要翻译: 用于合成式(I)的培哚普利的方法及其药学上可接受的盐。
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27.Process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates 有权
标题翻译: 工业上合成5- [双(羧甲基)氨基] -3-羧甲基-4-氰基-2-噻吩羧酸的四酯的方法,用于合成雷奈酸及其水合物的二价盐公开(公告)号:US07091364B2
公开(公告)日:2006-08-15
申请号:US10669302
申请日:2003-09-24
IPC分类号: C07D333/38
CPC分类号: C07D333/38
摘要: The process for the industrial synthesis of compounds of formula (I): wherein R and R′, which are the same or different, each represent linear or branched (C1–C6)alkyl. Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.
摘要翻译: 用于工业合成式(I)化合物的方法:其中R和R'相同或不同,各自表示直链或支链(C 1 -C 6 - 烷基。 应用于雷奈酸二价盐的合成,特别是雷奈酸锶及其水合物。
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