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公开(公告)号:US5716972A
公开(公告)日:1998-02-10
申请号:US256499
申请日:1994-11-22
IPC分类号: C07D401/04 , A61K31/44
CPC分类号: C07D401/04
摘要: The novel compounds of Formula (I) have been found to be useful cytokine suppressive agents and therefore useful in the treatment and prophylaxis of disease states mediated thereby.
摘要翻译: PCT No.PCT / US93 / 00675 Sec。 371日期:1994年11月22日 102(e)1994年11月22日PCT PCT 1993年1月13日提交已发现式(I)的新化合物是有用的细胞因子抑制剂,因此可用于治疗和预防由此介导的疾病状态。
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公开(公告)号:US20220272111A1
公开(公告)日:2022-08-25
申请号:US17527466
申请日:2021-11-16
申请人: SUPREETH HOSUR NAGESH RAO , NAVINDRA YADAV , RAVI SANKURATRI , ALOK LALIT WADHWA , ARIA RAHADIAN , BHARATHWAJ SANKARA VISWANATHAN , BRADY SCHULMAN , MATTHEW FINN , PAUL JOHN LESIAK , RAVI SHANKER PRASAD , VASIL DOCHKOV YORDANOV , YIWEI WANG , ZHIWEN ZHANG , UDAYAN JOSHI , SOUMYADEEP CHOUDHURY , MUHAMMADA FURQAN , MANISH ARIGALA
发明人: SUPREETH HOSUR NAGESH RAO , NAVINDRA YADAV , RAVI SANKURATRI , ALOK LALIT WADHWA , ARIA RAHADIAN , BHARATHWAJ SANKARA VISWANATHAN , BRADY SCHULMAN , MATTHEW FINN , PAUL JOHN LESIAK , RAVI SHANKER PRASAD , VASIL DOCHKOV YORDANOV , YIWEI WANG , ZHIWEN ZHANG , UDAYAN JOSHI , SOUMYADEEP CHOUDHURY , MUHAMMADA FURQAN , MANISH ARIGALA
IPC分类号: H04L9/40
摘要: In one aspect, a method for implementing a cloud-platform push for one or more known data breaches includes the step of, for each data breach of the one or more known data breaches, providing a functionality that maps one or more kill chains or Tactics, Techniques, and Procedures (TTPs) for a specified set of security dimensions. A step includes generating a security rule for each mapped kill chain or TTP based on the functionality that maps the one or more kill chains or Tactics, Techniques, and Procedures (TTPs) for a specified set of security dimensions. A step includes pushing the security rule to an enterprise so that the enterprise is aware of a vulnerability in the data breach. A step includes generating a customized posture for a Virtual private cloud (VPC) in the enterprise's cloud-based network. A step includes determining that the data breach can occur within the enterprise's cloud-based network.
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公开(公告)号:US11339108B2
公开(公告)日:2022-05-24
申请号:US17351520
申请日:2021-06-18
摘要: Methods and systems for preparing acetone from cumene hydroperoxide (CHP) are disclosed. The disclosed methods involve cleaving CHP to form a cleavage product stream. In some embodiments, the cleavage product stream is separated into an overhead stream and a bottoms stream. The bottoms stream is neutralized, washed and then treated in a crude acetone column to provide a crude acetone stream. The overhead stream of the cleavage product is flashed forward in the process, bypassing the neutralization, washing, and crude acetone column and is then combined with the crude acetone stream. The combined acetone streams are provided to an acetone product column. According to some embodiments, the acetone product column comprises a side draw for obtaining a recycle acetone stream, which is recycled to the cleavage reactor(s). The recycle acetone side draw may be located lower on the acetone product column than the point from which product acetone is obtained. The disclosed methods increase the efficiency of the process.
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公开(公告)号:US20210395180A1
公开(公告)日:2021-12-23
申请号:US17351520
申请日:2021-06-18
IPC分类号: C07C45/85
摘要: Methods and systems for preparing acetone from cumene hydroperoxide (CHP) are disclosed. The disclosed methods involve cleaving CHP to form a cleavage product stream. In some embodiments, the cleavage product stream is separated into an overhead stream and a bottoms stream. The bottoms stream is neutralized, washed and then treated in a crude acetone column to provide a crude acetone stream. The overhead stream of the cleavage product is flashed forward in the process, bypassing the neutralization, washing, and crude acetone column and is then combined with the crude acetone stream. The combined acetone streams are provided to an acetone product column. According to some embodiments, the acetone product column comprises a side draw for obtaining a recycle acetone stream, which is recycled to the cleavage reactor(s). The recycle acetone side draw may be located lower on the acetone product column than the point from which product acetone is obtained. The disclosed methods increase the efficiency of the process.
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公开(公告)号:US07638982B2
公开(公告)日:2009-12-29
申请号:US11520491
申请日:2006-09-13
申请人: Kong-Yin Leong , Ravi Shanker
发明人: Kong-Yin Leong , Ravi Shanker
IPC分类号: H02J7/00
CPC分类号: H02M3/07
摘要: A switched capacitor regulator in accordance with the present invention comprises a DC voltage source, a plurality of switches, a pumping capacitor, and a load capacitor. The plurality of switches may comprise semiconductor switches implemented in an integrated circuit (IC). The plurality of switches is configured to operate the switched capacitor regulator to place the regulator into a first charging stage and, alternately, a second charging stage. The switching between the first stage and the second stage results in the pumping capacitor being charged in opposing directions, while the load capacitor is always being charged in the same direction. The load capacitor is thus being charged in both the first charging stage and the second charging stage.
摘要翻译: 根据本发明的开关电容调节器包括直流电压源,多个开关,泵浦电容器和负载电容器。 多个开关可以包括在集成电路(IC)中实现的半导体开关。 多个开关被配置为操作开关电容器调节器以将调节器置于第一充电阶段中,并且可选地,将第二充电阶段放置。 第一级和第二级之间的切换导致泵送电容器沿相反的方向充电,而负载电容器总是沿相同的方向充电。 因此,负载电容器在第一充电阶段和第二充电阶段都被充电。
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公开(公告)号:US20070282009A1
公开(公告)日:2007-12-06
申请号:US11799447
申请日:2007-04-30
申请人: Marshall Crew , William Curatolo , Dwayne Friesen , Michael Gumkowski , Douglas Lorenz , James Nightlingale , Roger Ruggeri , Ravi Shanker
发明人: Marshall Crew , William Curatolo , Dwayne Friesen , Michael Gumkowski , Douglas Lorenz , James Nightlingale , Roger Ruggeri , Ravi Shanker
IPC分类号: A61K31/135
CPC分类号: A61K9/1652 , A61K9/146 , A61K9/1635 , A61K31/4196 , A61K31/47
摘要: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
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公开(公告)号:US20070210781A1
公开(公告)日:2007-09-13
申请号:US11520491
申请日:2006-09-13
申请人: Kong-Yin Leong , Ravi Shanker
发明人: Kong-Yin Leong , Ravi Shanker
IPC分类号: G05F1/00
CPC分类号: H02M3/07
摘要: A switched capacitor regulator in accordance with the present invention comprises a DC voltage source, a plurality of switches, a pumping capacitor, and a load capacitor. The plurality of switches may comprise semiconductor switches implemented in an integrated circuit (IC). The plurality of switches is configured to operate the switched capacitor regulator to place the regulator into a first charging stage and, alternately, a second charging stage. The switching between the first stage and the second stage results in the pumping capacitor being charged in opposing directions, while the load capacitor is always being charged in the same direction. The load capacitor is thus being charged in both the first charging stage and the second charging stage.
摘要翻译: 根据本发明的开关电容调节器包括直流电压源,多个开关,泵浦电容器和负载电容器。 多个开关可以包括在集成电路(IC)中实现的半导体开关。 多个开关被配置为操作开关电容器调节器以将调节器置于第一充电阶段中,并且可选地,将第二充电阶段放置。 第一级和第二级之间的切换导致泵送电容器沿相反的方向充电,而负载电容器总是沿相同的方向充电。 因此,负载电容器在第一充电阶段和第二充电阶段都被充电。
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公开(公告)号:US20060003011A1
公开(公告)日:2006-01-05
申请号:US11213118
申请日:2005-08-26
申请人: Marshall Crew , Dwayne Friesen , Rodney Ketner , Ravi Shanker , James West
发明人: Marshall Crew , Dwayne Friesen , Rodney Ketner , Ravi Shanker , James West
IPC分类号: A61K31/716 , A61K9/00 , A61K9/14
CPC分类号: A61K9/1611 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1652 , A61K31/00 , A61K31/404 , A61K31/405 , A61K31/4439 , A61K31/4706 , A61K31/4745 , A61K31/496 , A61K31/498 , A61K31/7024 , A61K31/717 , A61K2300/00
摘要: Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed.
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公开(公告)号:US06306883B1
公开(公告)日:2001-10-23
申请号:US09456019
申请日:1999-12-03
IPC分类号: C07D40104
CPC分类号: C07D401/04 , C07D403/04
摘要: This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cytokines by a compound of formula (I) and the treatment of cytokines mediated diseases, in mammals, by administration of said compound.
摘要翻译: 本发明涉及式(I)的新型吡唑化合物和包含式(I)化合物和药学上可接受的稀释剂或载体的药物组合物。本发明还涉及通过式(I)化合物抑制细胞因子的方法 )和通过施用所述化合物在哺乳动物中治疗细胞因子介导的疾病。
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公开(公告)号:US5998425A
公开(公告)日:1999-12-07
申请号:US454170
申请日:1996-11-15
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/505 , A61P11/00 , A61P29/00 , A61P43/00 , C07D401/04 , C07D403/04 , A61K31/405
CPC分类号: C07D401/04 , C07D403/04
摘要: This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier.This invention also relates to a method of inhibiting cytokines by a compound of Formula (I) and the treatment of cytokine mediated diseases, in mammals, by administration of said compound.
摘要翻译: PCT No.PCT / US95 / 06287 Sec。 371日期1996年11月15日 102(e)日期1996年11月15日PCT提交1995年5月16日PCT公布。 公开号WO95 / 31451 1995年11月23日,日本本发明涉及式(I)的新型吡唑化合物和包含式(I)化合物和药学上可接受的稀释剂或载体的药物组合物。 本发明还涉及通过施用所述化合物在哺乳动物中抑制式(I)化合物和细胞因子介导的疾病的治疗的方法。
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