公开(公告)号：US20230038754A1

公开(公告)日：2023-02-09

申请号：US17876268

申请日：2022-07-28

申请人： The Quaker Oats Company

发明人： El Hadji M. Dioum ,  YiFang Chu

IPC分类号： A61K31/716 ,  A61K31/192 ,  A61P29/00 ,  A61K9/00

摘要： A method of reducing systemic chronic inflammation in a subject by administering a composition capable of reducing the expression level of inflammatory biomarkers.

公开(公告)号：US20220387541A1

公开(公告)日：2022-12-08

申请号：US17834215

申请日：2022-06-07

申请人： GLOBAL PREVENTIVE MEDICINE BIOTECH COMPANY LIMITED

发明人： MEI-NAN TUAN ,  HIEN LY DOAN ,  ZI-YI HUANG ,  CHIA-YIN LEE ,  THUC ANH NGUYEN

IPC分类号： A61K36/82 ,  A61K36/87 ,  A61K36/185 ,  A61K36/63 ,  A61K36/28 ,  A61K31/716 ,  A61K36/48 ,  A61K31/353 ,  A61K31/7048 ,  A61K31/352 ,  A61K31/05 ,  A61P31/14

摘要： Coronavirus Disease 2019 (COVID-19) remains a threat with the emergence of new variants, especially Delta and Omicron, without specific effective therapeutic drugs. The present invention provides a method and a composition for preventing and treating COVID-19 (SARS-CoV-2) coronavirus infection which includes administering to a subject in need thereof one or more therapeutically effective doses of Virofree which comprises a pharmaceutically acceptable combination of grape seed extract, acerola cherry extract, olive leaf extract, marigold extract, green tea extract, pomegranate extract, yeast beta-glucan and soya bean extract for a treatment period.

公开(公告)号：US20220331352A1

公开(公告)日：2022-10-20

申请号：US17618311

申请日：2020-06-15

申请人： CP Pharmaceutical Qingdao Co., Ltd. ,  Marine Biomedical Research Institute of Qingdao Co., Ltd.

发明人： Jinbo YANG ,  Guangli YU ,  Qiaoling SONG ,  Lijuan WU ,  Jun ZHAO ,  Youjing LV ,  Chenyang ZHAO ,  Huashi GUAN

IPC分类号： A61K31/716 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04 ,  A61P7/00

摘要： An application of a glucan in the preparation of a drug. A β-1,3/1,6-glucan is used for preparing a pharmaceutical composition or formulation. The pharmaceutical composition or formulation can enhance the antitumor effect of immunotherapy, radiotherapy, or chemotherapy, and is used for treating leukopenia and/or thrombocytopenia.

公开(公告)号：US20220279828A1

公开(公告)日：2022-09-08

申请号：US17753150

申请日：2020-08-21

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： ALIREZA ABBASPOURRAD ,  JAVAD AMANI ,  MICHAEL JEDWAB ,  NANCY STEVENSON

IPC分类号： A23L29/269 ,  A23L29/262 ,  A23L29/238 ,  A23L29/256 ,  A23L29/244 ,  A23L2/52 ,  A23L33/10 ,  A23L33/00 ,  A61K31/716 ,  A61P1/00

摘要： A thickener is disclosed, as well as a nutritional product including the thickener, uses thereof, methods for the manufacture thereof, methods for improving the cohesiveness of a nutritional product, and related systems. The nutritional products have improved cohesiveness for promoting safer and more efficient swallowing of food boluses for individuals having swallowing difficulties such as dysphagia. In a preferred embodiment, the nutritional product includes a thickener comprising a beta-glucan and an additive. Preferably, the nutritional product has a relaxation time, determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment, of from 10 ms to 2000 ms at a temperature of 20° C.

公开(公告)号：US20220233577A1

公开(公告)日：2022-07-28

申请号：US16761107

申请日：2018-11-03

申请人： KALEIDO BIOSCIENCES, INC.

发明人： Molly Krisann Gibson ,  Nathan Wilson Stebbins ,  Ruth Thieroff-Ekerdt ,  Geoffrey A. von Maltzahn

IPC分类号： A61K31/716 ,  A61K47/10 ,  A61K35/741 ,  A61P3/12

摘要： Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.

公开(公告)号：US20220226358A1

公开(公告)日：2022-07-21

申请号：US17714240

申请日：2022-04-06

申请人： Showa Denko K.K.

发明人： Ichiro FUJITA ,  Shinji YAMAKI ,  Yuko NAKAGAMI

IPC分类号： A61K31/7034 ,  A61K8/60 ,  A61K8/73 ,  A61K31/716 ,  A61Q19/00

摘要： A mixture of inositol derivatives in which a sugar is bonded to inositol includes an inositol derivative (A10) in which total sugars bonded to one inositol molecule is 10 or more in terms of monosaccharide units. In addition, a mixture of inositol derivatives in which a sugar is bonded to inositol includes 5% by mass or more of an inositol derivative (A7), in which total sugars bonded to one inositol molecule is 7 or more in terms of monosaccharide units, with respect to a total amount of inositol derivatives (100% by mass).

公开(公告)号：US20220211732A1

公开(公告)日：2022-07-07

申请号：US17613220

申请日：2020-05-18

申请人： Evonik Operations GmbH

发明人： Bodo SPECKMANN ,  Christopher STUDTE

IPC分类号： A61K31/7004 ,  A61K31/202 ,  A61K31/732 ,  A61K31/716 ,  A61K31/719 ,  A61K31/702 ,  A61K31/736 ,  A61K9/48 ,  A61P1/14

摘要： The invention discloses preparations comprising L-rhamnose, and the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the form of either free fatty acids, fatty acid salts having an organic counter ion selected from lysine, arginine, ornithine, choline and mixtures of the same, or mixtures of free fatty acids and omega-3 fatty acid salts having an organic counter ion selected from lysine, arginine, ornithine, choline and use of a preparation as a feed or food supplement or in pharmaceutical compositions.

公开(公告)号：US20210353583A1

公开(公告)日：2021-11-18

申请号：US17319496

申请日：2021-05-13

申请人： Probioticsmart, LLC

发明人： Daniel J. DuBourdieu ,  Rajiv Lall

IPC分类号： A61K31/315 ,  C07F3/06 ,  A61K31/353 ,  A61K31/192 ,  A61K31/198 ,  A61K35/748 ,  A61K33/04 ,  A61K31/385 ,  A61K31/716 ,  A61K31/7008 ,  A61P37/06 ,  A61P39/06 ,  A61P3/02 ,  A23L33/00 ,  A23L33/105 ,  A23L33/16 ,  A23K20/111 ,  A23K10/16 ,  A23K20/20 ,  A23K50/75

摘要： The invention is directed to tetrahydrocurcuminoid-metal complexes. The complexes can be included in compositions that further include additional nutraceutical antimicrobials, antioxidants, and immune boosters. The tetrahydrocurcuminoid-metal complexes can be administered to animals to increase animal health, reduce stress, reduce oxidative stress, maintain health, improve health, improve immunity, improve vaccination efficacy, increase feed conversion rate, decrease pro-inflammatory cytokine levels, or any combination thereof in an animal. The tetrahydrocurcuminoid-metal complexes of the invention exhibit enhanced bioavailability relative to the individual, non-complexed components.

公开(公告)号：US20210338675A1

公开(公告)日：2021-11-04

申请号：US16967538

申请日：2019-02-07

申请人： L.E.A.F. HOLDINGS GROUP LLC

发明人： Clet NIYIKIZA ,  Victor Mandla MOYO

IPC分类号： A61K31/519 ,  A61K9/127 ,  A61K47/64 ,  A61K47/69 ,  A61K47/60 ,  A61K47/68 ,  A61K31/202 ,  A61K31/716 ,  A61K31/7032 ,  A61K31/683 ,  A61P35/00

摘要： The disclosure relates generally to alpha polyglutamated lometrexol, formulations containing liposomes filled with alpha polyglutamated lometrexol, methods of making the alpha polyglutamated lometrexol and liposome containing formulations, and methods of using polyglutamated alpha polyglutamated lometrexol and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).

公开(公告)号：US11147851B2

公开(公告)日：2021-10-19

申请号：US16478326

申请日：2018-01-05

申请人： SAFRAN

发明人： Rabih Khazaka ,  Stéphane Azzopardi ,  Donatien Henri Edouard Martineau

IPC分类号： H01L23/495 ,  A61K38/01 ,  A61K31/202 ,  A61K35/741 ,  A61K31/716 ,  A61K31/702 ,  A23L33/18 ,  A23L33/125 ,  A23L33/19 ,  A23L33/12 ,  A61K45/06

摘要： A method of fabricating an electronic power module by additive manufacturing, the electronic module including a substrate having an electrically insulating plate presenting opposite first and second faces, with a first metal layer arranged directly on the first face of the insulating plate, and a second metal layer arranged directly on the second face of the insulating plate. At least one of the metal layers is made by a step of depositing a thin layer of copper and a step of annealing the metal layer, and the method further includes a step of forming at least one thermomechanical transition layer on at least one of the first and second metal layers, the at least one thermomechanical transition layer including a material presenting a coefficient of thermal expansion that is less than that of the metal of the metal layer.