公开(公告)号：US4362737A

公开(公告)日：1982-12-07

申请号：US253876

申请日：1981-04-13

申请人： Rolf Schafer ,  Werner Schafer ,  Doris Schafer

发明人： Rolf Schafer ,  Werner Schafer ,  Doris Schafer

IPC分类号： C07D233/18 ,  C07F9/09 ,  C07F9/6506 ,  A61K31/415

CPC分类号： C07F9/65061 ,  C07D233/18 ,  C07F9/091

摘要： Amphoteric dissociating complexes which have a cationic group having the structure ##STR1## wherein: R.sub.1 is an aliphatic alkyl group having 6 to 22 carbons,R.sub.2 is a member of the group consisting of --R.sub.4 --(CH.sub.2 CH.sub.2)--COOH, --R.sub.4 --(CH.dbd.CH)COOH and --OPO.sub.3 H.sub.2, wherein R.sub.4 is --NH--, --NH--CO--, or --O--CO--, andR.sub.3 is hydrogen, --CH.sub.2 --COOH or --CH.sub.2 --CH.sub.2 --COOH; and an anionic group which is either a carboxylate having the formula.sup.- OOC--CH.sub.2 --(O--CH.sub.2 --CH.sub.2).sub.x --OC.sub.n H.sub.2n+1 or a phosphate having the formula.sup.= O.sub.3 PO--CH.sub.2 --CH.sub.2 --(OCH.sub.2 --CH.sub.2).sub.x --OC.sub.n H.sub.2n+1 wherein:n is 8 to 22 and x is 1 to 10; and z is 1 when the anionic radical is a carboxylate and z is 2 when the anionic radical is a phosphate are disclosed.The compositions are effective carriers for active pharmaceutical or cosmetic ingredients. The active ingredients may be ionically complexed with the cationic or anionic group of the amphoteric complex or may be covalently bonded to one of the groups of the complex. Alternatively, the active substances may be transported in the carriers as micellar inclusions.

摘要翻译： 具有结构为“IMAGE”或“IMAGE”的阳离子基团的两性离解络合物其中：R 1为具有6至22个碳的脂族烷基，R 2为-R 4 - （CH 2 CH 2）-COOH， -R4-（CH = CH）COOH和-OPO3H2，其中R4是-NH-，-NH-CO-或-O-CO-，R3是氢，-CH2-COOH或-CH2-CH2-COOH; 和具有式-OOC-CH2-（O-CH2-CH2）x-OCnH2n + 1的羧酸盐或具有式= O3PO-CH2-CH2-（OCH2-CH2）x-OCnH2n（OCH2-CH2）x-OCnH2n +1，其中n为8至22，x为1至10; 当阴离子基团为羧酸盐时，z为1，当阴离子基团为磷酸盐时，z为2。 组合物是活性药物或化妆品成分的有效载体。 活性成分可以与两性配合物的阳离子或阴离子基团离子地络合，或者可以共价键合到复合物的一个组中。 或者，活性物质可以作为胶束夹杂物在载体中运输。

公开(公告)号：US4329561A

公开(公告)日：1982-05-11

申请号：US011975

申请日：1979-02-14

申请人： Rolf Schafer ,  Sumanjit Singh

发明人： Rolf Schafer ,  Sumanjit Singh

IPC分类号： B23K11/24 ,  B23K11/25 ,  B23K11/34

CPC分类号： B23K11/34 ,  B23K11/25

摘要： A method of improving the reproducibility of the welds in an electric spot welding machine comprises prior to the initiation of a welding operation passing a preheating current of lower magnitude than the welding current through the parts to be welded. When either the total electrical workpiece resistance of the parts to be welded has fallen below a given limit or when its rate of decrease is slower than a predetermined limit the changeover from preheating current to welding current is effected.

摘要翻译： 提高电点焊机中焊缝再现性的方法包括在焊接操作开始之前通过比通过待焊接部件的焊接电流低的量级的预热电流。 当待焊接部件的总电工件电阻值低于给定极限时，或者当其降低速率比预定限制慢时，可以实现从预热电流到焊接电流的切换。

公开(公告)号：US4303822A

公开(公告)日：1981-12-01

申请号：US78179

申请日：1979-09-24

申请人： Peter Hirsch ,  Bernhard Wubbels ,  Rolf Schafer

发明人： Peter Hirsch ,  Bernhard Wubbels ,  Rolf Schafer

IPC分类号： B23K25/00 ,  B23K9/18

CPC分类号： B23K25/00

摘要： In an apparatus for electroslag welding of steel sheets with the aid of at least one wire electrode pair, a welding gap defined between the electrodes of the electrode pair, current-carrying conduits for the electrode pair, and a supply tube for supplying metal in a powdered state, and welding flux into the welding gap, the improvement includes a shielding device creating a duct along the current-carrying conduits. The duct, owing to the shielding device, is substantially free of any magnetic field, and the supply tube is positioned in the duct.

摘要翻译： 在用于借助于至少一个线电极对的钢板电渣焊接的装置中，限定在电极对的电极之间的焊接间隙，用于电极对的载流导管和用于在电极对中供应金属的供应管 粉末状态和将焊剂焊接到焊接间隙中，改进包括沿着载流导管形成管道的屏蔽装置。 由于屏蔽装置，管道基本上没有任何磁场，并且供应管被定位在管道中。

公开(公告)号：US4303482A

公开(公告)日：1981-12-01

申请号：US143661

申请日：1980-04-25

申请人： Joachim Buhne ,  Rolf Schafer ,  Axel Stoffel

发明人： Joachim Buhne ,  Rolf Schafer ,  Axel Stoffel

IPC分类号： C25F3/12 ,  C25F3/14 ,  H01L21/3063 ,  C25F7/00

CPC分类号： H01L21/3063 ,  C25F3/14 ,  H01L21/30635 ,  Y10S204/09

摘要： An apparatus and method for selectively electrochemically etching a surface is described. The use of the apparatus and the related method allows the establishment of etched planar surface which may be inclined with respect to the original surface.The apparatus has a cathode and multiple connectors which attach to the workpiece whose surface is to be etched. When the apparatus is operated the potential of the connectors are set so that the cathode is at least as negative as the lowest potential of the connectors.

摘要翻译： 描述了用于选择性地电化学蚀刻表面的设备和方法。 使用该装置和相关方法允许建立可相对于原始表面倾斜的蚀刻平面表面。 该装置具有阴极和多个连接器，其连接到要蚀刻其表面的工件。 当操作该装置时，设置连接器的电位使得阴极至少与连接器的最低电位一样负。

公开(公告)号：US5672575A

公开(公告)日：1997-09-30

申请号：US235778

申请日：1994-04-29

申请人： Rolf Schafer

发明人： Rolf Schafer

IPC分类号： C11D3/00 ,  C11D3/37 ,  C11D3/386

CPC分类号： C11D1/008 ,  C11D3/0078 ,  C11D3/3707

摘要： A contact lens cleaning solution containing an enzyme having proteolytic activity and a surfactant, and optionally also a chelating agent and urea, and a method of cleaning contact lenses utilizing this solution are described. The solution and method effectively remove deposits of proteinaceous material, mucins, lipids and calcium located either on or beneath the surface of the lens.

摘要翻译： 描述了含有具有蛋白水解活性的酶和表面活性剂以及任选地螯合剂和尿素的隐形眼镜清洁溶液以及使用该溶液来清洁隐形眼镜的方法。 该溶液和方法有效地去除位于透镜表面上或下方的蛋白质物质，粘蛋白，脂质和钙的沉积物。

公开(公告)号：US5627214A

公开(公告)日：1997-05-06

申请号：US389669

申请日：1995-02-16

申请人： Rolf Schafer ,  Ronald L. Schlitzer ,  Nissanke L. Dassanayake

发明人： Rolf Schafer ,  Ronald L. Schlitzer ,  Nissanke L. Dassanayake

IPC分类号： A61L12/14 ,  A61K31/14

CPC分类号： A61L12/14 ,  Y10S514/84 ,  Y10S514/912

摘要： Certain alkenyl diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.

摘要翻译： 描述了某些烯基二胺，其用于消毒和清洁隐形眼镜和保护眼用产品以及相关眼科组合物。

公开(公告)号：US5415837A

公开(公告)日：1995-05-16

申请号：US142624

申请日：1993-10-25

申请人： Rolf Schafer ,  Ronald L. Schlitzer ,  Nissanke L. Dassanayake

发明人： Rolf Schafer ,  Ronald L. Schlitzer ,  Nissanke L. Dassanayake

IPC分类号： A61L12/14 ,  A61L2/16

CPC分类号： A61L12/14 ,  Y10S514/84 ,  Y10S514/912

摘要： Certain alkenyl diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.

摘要翻译： 描述了某些烯基二胺，其用于消毒和清洁隐形眼镜和保护眼用产品以及相关眼科组合物。

公开(公告)号：US4908206A

公开(公告)日：1990-03-13

申请号：US95581

申请日：1987-09-10

申请人： Rolf Schafer ,  Hans Hitz

发明人： Rolf Schafer ,  Hans Hitz

IPC分类号： A61K35/54

CPC分类号： A61K35/54 ,  Y10S514/859 ,  Y10S514/878

摘要： From organs of embryonic mammalia a new extract of active ingredients is recovered which extract can be used for controlling a reduced blood flow through periperhic organs and through the brain and which extract can be also used for controlling acne vulgaris. The corresponding extracts are used as active ingredients of corresponding pharmaceutical preparations.The new pharmaceutically active extract is prepared according to a process in which polar substances having a molecular weight below 5000 are isolated from the embryonic mammalian organs avoiding any degradation of substances having a higher molecular weight. The finely divided embryonic mammalian organs are extracted with a mixture of water and a water soluble organic solvent which contains nor more than 30 vol.-% of water at an about neutral pH value for stirring and refluxing. The resulting solution is then submitted to a predetermined sequence of further drying steps, heating steps and cooling steps, and finally to a filtration with an ultramembrane filter in order to remove any substances having a molecular weight of about 5000. The extract is then finally concentrated under vacuum to yield a liquid concentrate or a dry residue.

摘要翻译： 从胚胎哺乳动物的器官中，回收了一种新的活性成分提取物，其提取物可用于控制通过perechic器官和通过脑的减少的血流，并且该提取物也可用于控制寻常痤疮。 相应的提取物用作相应药物制剂的活性成分。 根据其中从胚胎哺乳动物器官中分离分子量低于5000的极性物质避免任何具有较高分子量的物质降解的方法制备新的药物活性提取物。 细碎的胚胎哺乳动物器官用水和水溶性有机溶剂的混合物萃取，水溶性有机溶剂在约中性pH值下含有不超过30体积％的水，用于搅拌和回流。 然后将所得溶液进行预定的进一步干燥步骤，加热步骤和冷却步骤，最后用超滤膜过滤，以除去分子量为约5000的任何物质。然后将萃取物最终浓缩 在真空下产生液体浓缩物或干燥残余物。

公开(公告)号：US4151389A

公开(公告)日：1979-04-24

申请号：US762689

申请日：1977-01-26

申请人： Peter Hirsch ,  Bernhard Wubbels ,  Rolf Schafer

发明人： Peter Hirsch ,  Bernhard Wubbels ,  Rolf Schafer

IPC分类号： B23K25/00 ,  B23K9/18

CPC分类号： B23K25/00

摘要： A method of and apparatus for welding sheet steel panels by submerged arc welding is described. By providing one or, depending on the thickness of the sheet steel panels, more than one pair of closely spaced wire electrodes in the weld gap with the simultaneous introduction of additional filler metal carrying no current, preferably in the form of a metal powder, disadvantages associated with known methods may be avoided.

摘要翻译： 描述了通过埋弧焊焊接钢板的方法和装置。 通过提供一个或取决于钢板的厚度，在焊接间隙中多于一对紧密排列的线电极，同时引入不带电流的附加填充金属，优选为金属粉末的形式，缺点 可以避免与已知方法相关联。

公开(公告)号：US4046865A

公开(公告)日：1977-09-06

申请号：US744088

申请日：1976-11-22

申请人： Rolf Schafer

发明人： Rolf Schafer

IPC分类号： C01D3/06 ,  C01D3/14 ,  C01D3/16

CPC分类号： C01D3/16 ,  C01D3/06 ,  C01D3/14

摘要： Contacting rock salt containing at least one member of the group consisting of anhydrite and calcium sulfate as an impurity with an aqueous sodium chloride solution initially containing from about 200 to about 300 g/l of sodium chloride and having a calcium ion concentration of 0.01 to 0.5 g/l and a sulfate ion concentration of 0.1 to 15 g/l, the multiplication product of said calcium ion concentration and said sulfate ion concentration having a maximum value of 2, and discontinuing said contact after the sodium chloride brine has formed.

摘要翻译： 将含有至少一种由硬石膏和硫酸钙组成的组的岩盐与最初含有约200至约300g / l氯化钠并且钙离子浓度为0.01至0.5的氯化钠水溶液接触 g / l，硫酸根离子浓度为0.1〜15g / l，所述钙离子浓度与所述硫酸根离子浓度的乘积最大值为2，在形成氯化钠盐水后停止所述接触。