公开(公告)号：US20100294133A1

公开(公告)日：2010-11-25

申请号：US12846015

申请日：2010-07-29

Applicant: Sang Kook Lee ,  Justin David Bukowski ,  Carolyn Taylor Zelson ,  Mark Ephraim Levine

Inventor： Sang Kook Lee ,  Justin David Bukowski ,  Carolyn Taylor Zelson ,  Mark Ephraim Levine

IPC: B01D53/047

CPC classification number: B01D53/047 ,  B01D53/0446 ,  B01D2253/108 ,  B01D2256/12 ,  B01D2259/40007 ,  B01D2259/40073 ,  B01D2259/40075 ,  B01D2259/402 ,  B01D2259/404 ,  B01D2259/4533 ,  B01D2259/4541

Abstract: Pressure swing adsorption process for the separation of a feed gas mixture comprising (a) providing a pressure swing adsorption system comprising one or more composite beds, each composite bed comprising adsorbent material disposed in two or more vessels in parallel flow configuration, each vessel having a feed end and a product end; (b) performing cyclic sequential steps comprising adsorption/make product, withdrawing gas at decreasing pressure from the composite bed, purging the composite bed, and introducing gas into the composite bed at increasing pressure; and (c) for any of the sequential steps, setting a flow rate or flow rates of one or more gases selected from the group consisting of gas introduced into or withdrawn from the feed end or ends of any of the two or more vessels and gas introduced into or withdrawn from the product end or ends of any of the two or more vessels.

Abstract translation: 用于分离进料气体混合物的变压吸附方法，包括（a）提供包含一个或多个复合床的变压吸附系统，每个复合床包含以两个或多个平行流动构型设置在两个或更多个容器中的吸附材料，每个容器具有 进料端和产品端; （b）进行循环顺序步骤，包括吸附/制造产品，在复合床中以降低的压力抽出气体，清洗复合床，并在增加的压力下将气体引入复合床; 和（c）对于任何顺序步骤，设定一种或多种气体的流量或流速，所述气体选自引入或从两个或更多个容器和气体中的任何一个的进料端或末端引入的气体 引入或从产品的两个或更多个容器中的任何一个的末端引出。

公开(公告)号：US07572923B2

公开(公告)日：2009-08-11

申请号：US10586780

申请日：2005-01-26

Applicant: Yong-Chul Kim ,  Si Wouk Kim ,  Tae Sung Kim ,  Sang Kook Lee ,  Jae Il Kim ,  Jung-Hoon Yoon ,  Sang-Gun Ahn ,  Myoung Ju Moon

Inventor： Yong-Chul Kim ,  Si Wouk Kim ,  Tae Sung Kim ,  Sang Kook Lee ,  Jae Il Kim ,  Jung-Hoon Yoon ,  Sang-Gun Ahn ,  Myoung Ju Moon

IPC: C07D209/34 ,  A61K31/4015

CPC classification number: A61K31/403 ,  C07D209/36 ,  C07D209/40

Abstract: The present invention relates to an indirubin derivative having anticancer property by inhibiting cell proliferation as to human cancer cell line. More particularly, this invention provides the synthesis of indirubin derivative known as CDK(Cyclin-dependent kinase) inhibitor. Further, inhibition activity of proliferation as to human cancer cell line and apoptosis against induced-differentiation of said indirubin derivative are researched to develop a novel indirubin derivative having efficacious anticancer properties as to various human cell lines.

Abstract translation: 本发明涉及通过抑制人癌细胞系的细胞增殖而具有抗癌性的靛玉红衍生物。 更具体地，本发明提供称为CDK（细胞周期蛋白依赖性激酶）抑制剂的靛玉红衍生物的合成。 此外，研究了对人癌细胞系增殖的抑制活性和对所述靛玉红衍生物的诱导分化的凋亡，以开发出对各种人细胞系具有有效抗癌特性的新的靛玉红衍生物。

公开(公告)号：US07160884B2

公开(公告)日：2007-01-09

申请号：US11330073

申请日：2006-01-12

Applicant: Hea Young Park Choo ,  Jin Sung Kim ,  Hee Kyung Rhee ,  Hyun Joo Park ,  Sang Kook Lee ,  Chong Ock Lee

Inventor： Hea Young Park Choo ,  Jin Sung Kim ,  Hee Kyung Rhee ,  Hyun Joo Park ,  Sang Kook Lee ,  Chong Ock Lee

IPC: C07D487/04 ,  A61K31/5025

CPC classification number: C07D487/04

Abstract: The present invention relates to 1-/2-substituted-1H/-2H-[1,2,3]triazolo[4,5-g]phthalazine-4,9-dione compounds and their pharmaceutically acceptable salts, a process for preparing the compounds and a pharmaceutical composition comprising the compounds. The compounds are shown to effectively inhibit cell proliferation and are thus expected to be used for treatment or prevention or treatment of various cancers or as an ancillary(auxiliary) means of the same.

Abstract translation: 本发明涉及1- / 2-取代的1H / -2H- [1,2,3]三唑并[4,5-g]酞嗪-4,9-二酮化合物及其药学上可接受的盐，其制备方法 所述化合物和包含所述化合物的药物组合物。 这些化合物被证明有效地抑制细胞增殖，因此预期其用于治疗或预防或治疗各种癌症或作为其辅助（辅助）手段。

公开(公告)号：US20050261162A1

公开(公告)日：2005-11-24

申请号：US10472780

申请日：2002-03-22

Applicant: Kwang-Kyun Park ,  Jae-Kwan Hwang ,  Sang-Kook Lee ,  Won-Yoon Chung

Inventor： Kwang-Kyun Park ,  Jae-Kwan Hwang ,  Sang-Kook Lee ,  Won-Yoon Chung

IPC: A61K36/18 ,  A61K31/045 ,  A61K31/05 ,  A61P29/00 ,  A61P35/00 ,  A61K31/00

CPC classification number: A61K31/045

Abstract: The present invention relates to a pharmaceutical composition preventing cancer and treating cancer and inflammation, which is characterized in that including xanthorrhizol as an active principle. Xanthorrhizol not only inhibits mutagenesis and tumor formation, and enhances the activity of detoxification enzyme of carcinogen, induces apoptosis of cancer cell, and suppresses the activity of COX-2 and iNOS which are related to tumor promotion and inflammatory reaction. Thus, a pharmaceutical composition including xanthorrhizol can be utilized for prevention of cancer and treatment of cancer and inflammation.

Abstract translation: 本发明涉及一种预防癌症和治疗癌症和炎症的药物组合物，其特征在于包括作为活性成分的黄嘌呤。 Xanthorrhizol不仅抑制诱变和肿瘤形成，增强致癌物解毒酶的活性，诱导癌细胞凋亡，抑制与肿瘤促进和炎症反应相关的COX-2和iNOS的活性。 因此，包含黄原酸的药物组合物可以用于预防癌症和治疗癌症和炎症。