公开(公告)号：US20060148908A1

公开(公告)日：2006-07-06

申请号：US10562412

申请日：2004-06-24

申请人： Kwang-Kyun Park ,  Won-Yoon Chung ,  Gyoung-Ok Hong ,  Jac-Kwan Hwang

发明人： Kwang-Kyun Park ,  Won-Yoon Chung ,  Gyoung-Ok Hong ,  Jac-Kwan Hwang

IPC分类号： A61K31/05 ,  A61K31/28 ,  A61K33/24

CPC分类号： A61K31/045 ,  A61K31/05 ,  A61K31/28 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed are a suppressant of toxicity such as hepatotoxicity and nephrotoxicity, induced by cancer chemotherapeutic agent, and a composition of cancer chemotherapeutic agent containing the suppressant. The suppressant of toxicity induced by a cancer chemotherapeutic agent contains xanthorrhizol as an active ingredient. Xanthorrhizol shows an excellent ability in suppressing ill effects generated by dosage of cancer chemotherapeutic agent, such as hepatotoxicity and nephrotoxicity.

摘要翻译： 公开了由癌症化学治疗剂诱导的毒性抑制剂如肝毒性和肾毒性，以及含有抑制剂的癌症化学治疗剂的组合物。 癌症化学治疗剂诱导的毒性抑制剂含有作为活性成分的黄嘌呤。 Xanthorrhizol具有优异的抑制癌症化疗药物剂量引起的不良反应的能力，如肝毒性和肾毒性。

公开(公告)号：US20050261162A1

公开(公告)日：2005-11-24

申请号：US10472780

申请日：2002-03-22

申请人： Kwang-Kyun Park ,  Jae-Kwan Hwang ,  Sang-Kook Lee ,  Won-Yoon Chung

发明人： Kwang-Kyun Park ,  Jae-Kwan Hwang ,  Sang-Kook Lee ,  Won-Yoon Chung

IPC分类号： A61K36/18 ,  A61K31/045 ,  A61K31/05 ,  A61P29/00 ,  A61P35/00 ,  A61K31/00

CPC分类号： A61K31/045

摘要： The present invention relates to a pharmaceutical composition preventing cancer and treating cancer and inflammation, which is characterized in that including xanthorrhizol as an active principle. Xanthorrhizol not only inhibits mutagenesis and tumor formation, and enhances the activity of detoxification enzyme of carcinogen, induces apoptosis of cancer cell, and suppresses the activity of COX-2 and iNOS which are related to tumor promotion and inflammatory reaction. Thus, a pharmaceutical composition including xanthorrhizol can be utilized for prevention of cancer and treatment of cancer and inflammation.

摘要翻译： 本发明涉及一种预防癌症和治疗癌症和炎症的药物组合物，其特征在于包括作为活性成分的黄嘌呤。 Xanthorrhizol不仅抑制诱变和肿瘤形成，增强致癌物解毒酶的活性，诱导癌细胞凋亡，抑制与肿瘤促进和炎症反应相关的COX-2和iNOS的活性。 因此，包含黄原酸的药物组合物可以用于预防癌症和治疗癌症和炎症。

公开(公告)号：US20090156688A1

公开(公告)日：2009-06-18

申请号：US12338912

申请日：2008-12-18

申请人： Kwang-Kyun Park ,  Won-Yoon Chung ,  Gyoung-Ok Hong ,  Jae-Kwan Hwang

发明人： Kwang-Kyun Park ,  Won-Yoon Chung ,  Gyoung-Ok Hong ,  Jae-Kwan Hwang

IPC分类号： A61K31/05

CPC分类号： A61K31/045 ,  A61K31/05 ,  A61K31/28 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed are a suppressant of toxicity such as hepatotoxicity and nephrotoxicity, induced by cancer chemotherapeutic agent, and a composition of cancer chemotherapeutic agent containing the suppressant. The suppressant of toxicity induced by a cancer chemotherapeutic agent contains xanthorrhizol as an active ingredient. Xanthorrhizol shows an excellent ability in suppressing ill effects generated by dosage of cancer chemotherapeutic agent, such as hepatotoxicity and nephrotoxicity.

摘要翻译： 公开了由癌症化学治疗剂诱导的毒性抑制剂如肝毒性和肾毒性，以及含有抑制剂的癌症化学治疗剂的组合物。 癌症化学治疗剂诱导的毒性抑制剂含有作为活性成分的黄嘌呤。 Xanthorrhizol具有优异的抑制癌症化疗药物剂量引起的不良反应的能力，如肝毒性和肾毒性。