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49 条记录 (耗时 0.029 秒)

    METHODS AND COMPOSITIONS FOR TREATING PAIN ASSOCIATED WITH INFLAMMATION
    21.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING PAIN ASSOCIATED WITH INFLAMMATION 有权

    公开(公告)号：US20210087297A1

    公开(公告)日：2021-03-25

    申请号：US15863828

    申请日：2018-01-05

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： C07K16/44 ,  A61P19/02 ,  A61K39/00 ,  A61K47/64

    摘要： A method of treating pain associated with inflammation comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating pain associated with inflammation comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of pain associated with inflammation comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

    Humanized monoclonal advanced glycation end-product antibody
    22.
    发明授权
    Humanized monoclonal advanced glycation end-product antibody 有权

    公开(公告)号：US10919957B2

    公开(公告)日：2021-02-16

    申请号：US15953244

    申请日：2018-04-13

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： C07K16/44 ,  A61K39/00 ,  C07K16/18 ,  A61K47/68 ,  A61K47/69

    摘要： A humanized monoclonal antibody that binds to an advanced glycation end-product-modified protein or peptide on a cell comprises a heavy chain and a light chain. The antibody binds a carboxymethyllysine-modified protein or peptide. A composition comprises a humanized monoclonal antibody that binds to an advanced glycation end-product-modified protein or peptide on a cell and a pharmaceutically acceptable carrier.

    Anti-age antibodies and methods of use thereof
    23.
    发明授权
    Anti-age antibodies and methods of use thereof 有权

    公开(公告)号：US10889634B2

    公开(公告)日：2021-01-12

    申请号：US15768425

    申请日：2016-05-27

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： C07K16/18 ,  C07K16/46 ,  A61K47/68 ,  A61P21/00 ,  A61K39/00

    摘要： An anti-AGE antibody comprises a protein or peptide that comprises at least one amino acid sequence having at least 90% sequence identity, preferably at least 95% sequence identity, more preferably at least 98% sequence identity, with specific amino acid sequences. The anti-AGE antibody binds to a protein or peptide that exhibits a carboxymethyllysine modification. The anti-AGE antibody may be used for killing senescent cells, killing partially-functional or non-functional cells, treating sarcopenia, promoting tissue or organ regeneration, promoting regenerative processes or overcoming aging effects, treating atherosclerosis, preventing or delaying the onset of cataracts, preventing or delaying the onset of loss of adipose tissue, increasing health span, preventing or delaying the onset of lordokyphosis, treating inflammation or autoimmune disorders, treating neurodegenerative disorders or treating cancer.

    METHODS AND COMPOSITIONS FOR TREATING CHRONIC EFFECTS OF RADIATION AND CHEMICAL EXPOSURE
    29.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING CHRONIC EFFECTS OF RADIATION AND CHEMICAL EXPOSURE 有权

    公开(公告)号：US20220175916A1

    公开(公告)日：2022-06-09

    申请号：US17262684

    申请日：2019-07-23

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： A61K39/395 ,  A61P35/04 ,  C07K16/44

    摘要： A method of treating a chronic effect of radiation or chemical exposure comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating a chronic effect of radiation or chemical exposure comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of a chronic effect of radiation or chemical exposure comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.