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49 条记录 (耗时 0.041 秒)

    METHODS AND COMPOSITIONS FOR TREATING KIDNEY DISEASES
    1.
    发明公开
    METHODS AND COMPOSITIONS FOR TREATING KIDNEY DISEASES 审中-公开

    公开(公告)号：US20240000930A1

    公开(公告)日：2024-01-04

    申请号：US18265205

    申请日：2021-12-09

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： A61K39/395 ,  A61K39/00 ,  A61P13/12

    CPC分类号： A61K39/3955 ,  A61K39/0005 ,  A61P13/12

    摘要： A method of treating or preventing the onset of kidney disease comprises administering to a subject a composition comprising an anti-AGE antibody. The anti-AGE antibody binds an AGE antigen comprising at least one protein or peptide that exhibits AGE modifications selected from the group consisting of FFI, pyrraline, AFGP, ALI, carboxymethyllysine, carboxyethyllysine and pentosidine. A method of treating or preventing the onset of kidney disease comprises administering to a subject a vaccine comprising an AGE antigen.

    METHODS AND COMPOSITIONS FOR TREATING DISEASE-RELATED CACHEXIA
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING DISEASE-RELATED CACHEXIA 有权

    公开(公告)号：US20210253737A1

    公开(公告)日：2021-08-19

    申请号：US17209554

    申请日：2021-03-23

    申请人： SIWA Corporation

    发明人： Lewis S. Gruber

    IPC分类号： C07K16/44 ,  A61K39/395 ,  A61K39/00 ,  A61K47/64

    摘要： A method of treating disease-related cachexia comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating disease-related cachexia comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of disease-related cachexia comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

    Methods and compositions for treating pain associated with inflammation
    4.
    发明授权
    Methods and compositions for treating pain associated with inflammation 有权

    公开(公告)号：US10961321B1

    公开(公告)日：2021-03-30

    申请号：US15863828

    申请日：2018-01-05

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： A61P19/02 ,  A61K39/00 ,  A61K39/395 ,  C07K16/44 ,  A61K47/64

    摘要： A method of treating pain associated with inflammation comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating pain associated with inflammation comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of pain associated with inflammation comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

    PRODUCT AND METHOD FOR TREATING SARCOPENIA
    7.
    发明申请
    PRODUCT AND METHOD FOR TREATING SARCOPENIA 审中-公开
    用于治疗恐怖症的产品和方法

    公开(公告)号：US20160215043A1

    公开(公告)日：2016-07-28

    申请号：US14974561

    申请日：2015-12-18

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： C07K16/18 ,  A61K39/395

    CPC分类号： C07K16/44 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/92

    摘要： A method of treating sarcopenia comprises administering to a subject a composition comprising an anti-AGE antibody. The method may also be used for preventing or delaying the onset of cataracts, preventing or delaying the onset of loss of adipose tissue, increasing health span, and preventing or delaying the onset of lordokyphosis.

    摘要翻译： 治疗肌肉减少症的方法包括向受试者施用包含抗AGE抗体的组合物。 该方法还可用于预防或延迟白内障的发作，预防或延迟脂肪组织损失的发生，增加健康范围，以及防止或延缓头晕毒素的发作。

    METHODS, COMPOSITIONS AND APPARATUSES FOR FACILITATING REGENERATION
    8.
    发明申请
    METHODS, COMPOSITIONS AND APPARATUSES FOR FACILITATING REGENERATION 审中-公开
    方法，组合物和装置，以促进再生

    公开(公告)号：US20160152697A1

    公开(公告)日：2016-06-02

    申请号：US14932200

    申请日：2015-11-04

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： C07K16/18 ,  A61K47/48

    CPC分类号： C07K16/18 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/20 ,  A61B2018/0047 ,  A61K39/395 ,  A61K47/6803 ,  A61K47/6843 ,  A61N5/10 ,  A61N7/00 ,  A61N7/02 ,  C07K2317/21 ,  C07K2317/73 ,  G01N33/5091

    摘要： A polypeptide having at least 70% homology, in particular 80%, 90% or 95% homology to the polypeptide of SEQ ID No 2 representing the wild-type of the protein insect metalloproteinase inhibitor IMPIa and having at least one mutation at position 35, 36 and/or 39 of the amino acid sequence of IMPIa and the polypeptide having an IC50 value to thermolysine of less than the IC50 value of IMPIa wherein—the nonpolar amino acid isoleucine at position 35 of IMPIα is replaced either by a nonpolar amino acid selected from the group consisting of leucine, methionine and phenylalanine or by polar amino acid selected from the group consisting of cysteine, asparagine, glutamine, histidine, lysine and arginine; and/or—the nonpolar amino acid isoleucine at position 36 of IMPIa is replaced either by a nonpolar amino acid selected from the group consisting of valine, phenylalanine and tryptophan or by polar amino acid selected from the group consisting of tyrosine, serine, threonine, asparagine, glutamine, histidine, lysine and arginine; and/or—the polar amino acid position 39 of IMPIa is replaced either by the nonpolar amino acid valine or by the polar amino acids histidine or lysine.

    摘要翻译： 与代表野生型蛋白质昆虫金属蛋白酶抑制剂IMPIa的SEQ ID No 2的多肽具有至少70％同源性，特别是80％，90％或95％同源性的多肽，并且在35位具有至少一个突变， IMPIa的氨基酸序列的36和/或39以及具有低于IMPIa的IC50值的ICOH值的多肽，其中IMPIα的第35位的非极性氨基酸异亮氨酸被选择的非极性氨基酸取代 来自由亮氨酸，甲硫氨酸和苯丙氨酸组成的组，或选自半胱氨酸，天冬酰胺，谷氨酰胺，组氨酸，赖氨酸和精氨酸的极性氨基酸; 和/或 - IMPIa位置36处的非极性氨基酸异亮氨酸被选自缬氨酸，苯丙氨酸和色氨酸的非极性氨基酸或选自下组的极性氨基酸取代：酪氨酸，丝氨酸，苏氨酸， 天冬酰胺，谷氨酰胺，组氨酸，赖氨酸和精氨酸; 和/或 - IMPIa的极性氨基酸位置39被非极性氨基酸缬氨酸或极性氨基酸组氨酸或赖氨酸取代。

    Methods and compositions for treating diabetes and diabetic complications
    9.
    发明授权
    Methods and compositions for treating diabetes and diabetic complications 有权

    公开(公告)号：US11518801B1

    公开(公告)日：2022-12-06

    申请号：US16228293

    申请日：2018-12-20

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： A61P3/10 ,  A61K39/00 ,  A61K39/395 ,  C07K16/18 ,  A61K9/00

    摘要： A method of treating or preventing the onset of diabetes or diabetic complications comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating or preventing the onset of diabetes or diabetic complications comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of diabetes or diabetic complications comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

    Methods and compositions for treating disease-related cachexia
    10.
    发明授权
    Methods and compositions for treating disease-related cachexia 有权

    公开(公告)号：US10995151B1

    公开(公告)日：2021-05-04

    申请号：US15863784

    申请日：2018-01-05

    申请人： Siwa Corporation

    发明人： Lewis S. Gruber

    IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/44 ,  A61K47/64

    摘要： A method of treating disease-related cachexia comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating disease-related cachexia comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of disease-related cachexia comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.