公开(公告)号：US20220133775A1

公开(公告)日：2022-05-05

申请号：US17530051

申请日：2021-11-18

Applicant: Bio-Path Holdings, Inc. ,  Thomas Jefferson University

Inventor： Ana Ashizawa ,  Douglas Craig Hooper ,  David W. Andrews

IPC: A61K31/7125 ,  A61K47/69 ,  C12N15/11 ,  C12N15/113 ,  A61P35/00 ,  A61K45/06 ,  A61K9/00

Abstract: Provided herein are methods of treating cancer or an autoimmune disease comprising administering a liposome that comprises neutral phospholipids and a P-ethoxy oligonucleotide that targets a IGF-1R-encoding polynucleotide.

公开(公告)号：US11311622B2

公开(公告)日：2022-04-26

申请号：US16460957

申请日：2019-07-02

Applicant: CITY OF HOPE ,  Thomas Jefferson University

Inventor： John C. Williams ,  Cindy Zer ,  Kendra N. Avery ,  Ulrich Rodeck ,  Joshua M. Donaldson ,  Csaba Kari

IPC: A61K47/55 ,  C07K16/28 ,  C07K16/30 ,  C07K16/22

Abstract: In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.

公开(公告)号：US11213225B2

公开(公告)日：2022-01-04

申请号：US17308084

申请日：2021-05-05

Applicant: Thomas Jefferson University ,  RTM Vital Signs LLC

Inventor： Jeffrey I Joseph ,  Noud Van Helmond ,  Marc C Torjman ,  Denise L Devine ,  Nance K Dicciani ,  Channy Loeum

IPC: A61B5/113 ,  A61B5/00 ,  A61B5/022 ,  A61B5/08 ,  A61B7/00 ,  A61B5/318

Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

公开(公告)号：US20210393960A1

公开(公告)日：2021-12-23

申请号：US17358851

申请日：2021-06-25

Applicant: The Trustees of the University of Pennsylvania ,  Thomas Jefferson University

Inventor： Daniel Kacy Cullen ,  James P. Harris ,  John A. Wolf ,  Han-Chiao Isaac Chen ,  Douglas H. Smith ,  Mijail Serruya

IPC: A61N1/36 ,  A61N1/05 ,  A61B5/00 ,  A61B5/24 ,  A61B5/291 ,  A61N5/06

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

公开(公告)号：US20210324486A1

公开(公告)日：2021-10-21

申请号：US17235348

申请日：2021-04-20

Applicant: Thomas Jefferson University

Inventor： Isidore Rigoutsos

IPC: C12Q1/70

Abstract: In various aspects and embodiments the invention provides a method of detecting SARS-CoV-2 in a sample obtained from a subject, the method comprising contacting the sample with a with a composition comprising a plurality of PCR primers targeting at least one sequence selected from the group consisting of SEQ ID NOS: 1-559, thereby forming a PCR mixture; conducting PCR amplification of the PCR mixture and detection of the at least one sequence selected from the group consisting of SEQ ID NOS: 1-559; wherein an elevated level of the at least one sequence selected from the group consisting of SEQ ID NOS: 1-559 indicates the presence of SARS-CoV-2 in the sample.

公开(公告)号：US20210261861A1

公开(公告)日：2021-08-26

申请号：US17252520

申请日：2019-06-17

Applicant: THOMAS JEFFERSON UNIVERSITY ,  CUKUROVA UNIVERSITY

Inventor： Zehra Yegingil ,  Enver Bulur ,  Volkan Altunal ,  Yan Yu ,  Veysi Guckan ,  Adam Dicker

IPC: C09K11/77 ,  G01T1/10 ,  C01F3/02

Abstract: The present invention relates generally in part to BeO-based compounds that are capable of storing at least part of the energy of incident ionizing radiation and releasing at least part of the stored energy upon optical stimulation and heating. BeO-based compounds dosimetry was also developed in instrumentation, application and fundamental investigations. The present disclosure further relates the to the investigation of a BeO-based optically stimulated luminescence (OSL) dosimeter together with an OSL reader, and discusses the design and operation of an OSL reader, suitable to measure OSL emission of BeO-based dosimeters, for example beryllium oxide doped with sodium, dysprosium and erbium. The present disclosure further relates to the use of BeO-based compounds comprising BeO and at least one dopant selected from the group consisting of sodium, dysprosium and erbium as a fiber-coupled OSL dosimeter.

公开(公告)号：US11077133B2

公开(公告)日：2021-08-03

申请号：US16711470

申请日：2019-12-12

Applicant: Thomas Jefferson University

Inventor： David W. Andrews ,  Douglas C. Hooper

IPC: C07H21/04 ,  A61K31/713 ,  A61K31/7125 ,  C12N15/113 ,  A61K45/06

Abstract: The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the selective reduction of M2 cells by targeting expression of IGF-1R in these cells. The present disclosure further provides methods for treating cancer and enhancing therapeutic by targeting expression of IGF-1R in M2 cells in patients. The pharmaceutical composition of the present invention is effective when administered systemically to subjects in need thereof. The ease of administration of the pharmaceutical composition facilitates treatment and enhances patient compliance.

公开(公告)号：US20210172091A1

公开(公告)日：2021-06-10

申请号：US17248491

申请日：2021-01-27

Applicant: Thomas Jefferson University ,  Ecofibre USA Inc.

Inventor： Mark Sunderland ,  Jeffrey William Bruner ,  Lee Benjamin Williams

IPC: D01F8/02 ,  A41D13/11 ,  C08K5/053 ,  C08K5/01 ,  C08K5/1545 ,  D01F8/06 ,  D01F8/12 ,  D01F8/14 ,  D01F8/18 ,  C08J5/04 ,  D01F1/10

Abstract: A process of forming a fiber comprised of a plurality of bio-char particles, comprising: combining a portion of a polymer with a hemp derivative, said hemp derivative selected form a hemp carbon made by pyrolyzing a quantity of hemp stalk at between 1100-1500° C. to create a char; adding the char to a milling vessel and milling the char for a period of between 1 to 16 hours, and a full spectrum hemp extract, or combinations thereof, wherein the polymer and hemp derivative are extruded to form a fiber.

公开(公告)号：US11000191B2

公开(公告)日：2021-05-11

申请号：US16937691

申请日：2020-07-24

Applicant: Thomas Jefferson University ,  RTM Vital Signs LLC

Inventor： Jeffrey I Joseph ,  Marc C Torjman ,  Denise L Devine ,  Nance K Dicciani ,  Channy Loeum

IPC: A61B5/0205 ,  A61B5/145 ,  A61B5/00 ,  A61B5/024 ,  A61B5/08 ,  A61B5/091

Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

公开(公告)号：US20210052875A1

公开(公告)日：2021-02-25

申请号：US16964693

申请日：2019-01-24

Applicant: Brendan LAURENZI ,  THOMAS JEFFERSON UNIVERSITY ,  IMVAX, INC.

Inventor： Brendan LAURENZI ,  David ANDREWS ,  William HITCHINGS ,  Dominic VENTURA ,  Kara PIGOTT ,  Douglas Craig Hooper

IPC: A61M39/02 ,  C12N15/113 ,  A61K35/13 ,  A61K31/7125 ,  A61K9/00

Abstract: A biodiffusion chamber for performing autologous cell vaccination is provided. The biodiffusion chamber is adapted for insertion into and removal from a subject. In some embodiments, the biodiffusion chamber comprises (i) a chamber body defining a hollow cavity and including a first surface and a second surface, (ii) a first semi-permeable membrane coupled to the first surface, (iii) a second semi-permeable membrane coupled to the second surface, and (iv) an element and/or feature adapted for removing the biodiffusion chamber from the subject. The first semi-permeable membrane and the second semi-permeable membrane are permeable to fluids and soluble factors but are not permeable to cells. In some embodiments, composition comprising a therapeutically effective amount of an antisense oligodeoxynucleotide is inserted into the biodiffusion chamber and allowed to diffuse out of the biodiffusion chamber and into the subject via at least one of the first semi-permeable membrane or the second semi-permeable membrane.