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34 条记录 (耗时 0.016 秒)

    Methods for treating or ameliorating a melanoma and killing melanoma cells
    27.
    发明授权
    Methods for treating or ameliorating a melanoma and killing melanoma cells 有权
    用于治疗或改善黑素瘤并杀死黑素瘤细胞的方法

    公开(公告)号：US09045401B2

    公开(公告)日：2015-06-02

    申请号：US12600930

    申请日：2008-05-21

    申请人： William Gerwick ,  Wolfgang Wrasidlo ,  Dennis Carson ,  Dwayne Stupack ,  Takashi Suyama

    发明人： William Gerwick ,  Wolfgang Wrasidlo ,  Dennis Carson ,  Dwayne Stupack ,  Takashi Suyama

    IPC分类号： A61K9/127 ,  C07C323/60 ,  C07C233/47

    CPC分类号： C07C323/60 ,  C07C233/47

    摘要： The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.

    摘要翻译： 本发明提供了新颖的组合物 - 脂肽和类似物，包括胞质酰胺A和胞囊酰胺A变体和类似物，以及包含它们的药物组合物，脂质体和纳米颗粒，以及制备和使用它们的方法。 在一个实施方案中，这些脂肽和类似物用于诱导细胞凋亡，细胞可以是正常细胞，功能障碍细胞和/或癌症（肿瘤）细胞。 在替代实施方案中，本发明的组合物，包括本发明的脂肽和类似物以及包含它们的药物组合物用于治疗或改善（包括减缓正常，功能障碍（例如异常增殖）和/ 或肿瘤相关血管，包括内皮细胞和/或毛细胞生长; 包括与肿瘤相关的新血管生成（内部，提供血液供应）。

    Robot and robot hand
    28.
    发明授权
    Robot and robot hand 有权
    机器人和机器人手

    公开(公告)号：US08857875B2

    公开(公告)日：2014-10-14

    申请号：US13487262

    申请日：2012-06-04

    申请人： Takashi Suyama ,  Makoto Umeno

    发明人： Takashi Suyama ,  Makoto Umeno

    IPC分类号： B66C1/42 ,  B25J15/00

    CPC分类号： B25J15/0052 ,  Y10S901/31

    摘要： A robot includes a robot arm. A robot hand is disposed at a distal end of the robot arm and grips an object. The robot hand includes an air chuck device including a pair of pistons and an air cylinder. The air cylinder opens and closes the pistons in parallel to one another. A pair of first gripping members are disposed at a first side of the pistons and move close to and apart from one another within a first movable range on a movable plane. A pair of second gripping members are disposed at a second side of the pistons and move close to and apart from one another within a second movable range different from the first movable range on the movable plane. The robot hand pivots relative to the distal end of the robot arm about a pivot axis approximately perpendicular to the movable plane.

    摘要翻译： 机器人包括机器人臂。 机器人手设置在机器人手臂的远端并夹持物体。 机器人手包括包括一对活塞和气缸的空气卡盘装置。 气缸彼此平行地打开和关闭活塞。 一对第一夹持构件设置在活塞的第一侧并且在可移动平面上的第一可移动范围内彼此靠近和分开地移动。 一对第二夹持构件设置在活塞的第二侧，并且在与可移动平面上的第一可移动范围不同的第二可移动范围内彼此靠近和分开地移动。 机械手相对于机器人臂的远端围绕大致垂直于可移动平面的枢转轴线枢转。

    PROCESSING SYSTEM, ROBOT, AND PRODUCT MANUFACTURING METHOD
    29.
    发明申请
    PROCESSING SYSTEM, ROBOT, AND PRODUCT MANUFACTURING METHOD 有权
    加工系统，机器人及产品制造方法

    公开(公告)号：US20120083920A1

    公开(公告)日：2012-04-05

    申请号：US13252353

    申请日：2011-10-04

    申请人： Takashi Suyama ,  Junichi Imatome ,  Toru Kajiwara ,  Yoshiaki Yamamoto

    发明人： Takashi Suyama ,  Junichi Imatome ,  Toru Kajiwara ,  Yoshiaki Yamamoto

    IPC分类号： B25J9/16 ,  B65G49/00 ,  B65B5/00 ,  B25J18/00 ,  B25J15/06

    CPC分类号： B65B5/105 ,  B25J9/0084 ,  B25J9/0087 ,  B25J9/0093 ,  B65B5/08 ,  B65B35/18 ,  B65B43/46 ,  B65B55/20

    摘要： A processing system according to embodiments has an article supplier which supplies an article; a first conveyor which conveys an object to be processed; a workbench which is provided on the downstream side of the first conveyor and places thereon the object to be processed, conveyed by the first conveyor; a robot which takes out the article from the article supplier and subjects the object to be processed, placed on the workbench, to an operation using the article according to a previously instructed operation movement; and a second conveyor which is provided on the downstream side of the workbench and conveys the object to be processed, which has been subjected to the operation by the robot.

    摘要翻译： 根据实施例的处理系统具有供应物品的物品供应商; 传送待加工物体的第一输送机; 工作台，其设置在第一输送机的下游侧，并在其上放置由第一输送机输送的待处理物体; 机器人，其从文章供应商取出物品，并将放置在工作台上的待处理物体根据先前指示的操作运动进行使用该物品的操作; 以及设置在工作台的下游侧并输送被机器人进行了操作的待处理物体的第二输送机。

    Electric connector
    30.
    发明申请
    Electric connector 审中-公开

    公开(公告)号：US20060128204A1

    公开(公告)日：2006-06-15

    申请号：US11353144

    申请日：2006-02-14

    申请人： Masayuki Hiramoto ,  Takashi Suyama ,  Terumi Nakashima

    发明人： Masayuki Hiramoto ,  Takashi Suyama ,  Terumi Nakashima

    IPC分类号： H01R11/20

    CPC分类号： H01R4/2466 ,  H01R12/79 ,  Y10S439/942

    摘要： An electric connector having a housing in which there are disposed, side by side, a plurality of wire holding portions for holding the insulations of insulated wires. Each wire holding portion has: a pair of wire holding pieces disposed as facing each other to form a wire holding groove; and wire hold-down pieces not only for guiding, in the vertical direction, the insertion of the insulated wire into the wire holding groove, but also for preventing the insulated wire from coming off from the wire holding groove. The plurality of wire holding portions has: a first wire holding portion having wire hold-down pieces at a first wire hold-down position; and a second wire holding portion disposed adjacent to the first wire holding portion, and having wire hold-down pieces at a second wire hold-down position different from the first wire hold-down position.