公开(公告)号：US07959781B2

公开(公告)日：2011-06-14

申请号：US11648033

申请日：2006-12-29

Applicant: Younghee Lee ,  Hakyu Choi ,  Seongchu Lim

Inventor： Younghee Lee ,  Hakyu Choi ,  Seongchu Lim

IPC: B01D57/02

CPC classification number: C25D1/12

Abstract: The present invention provides an apparatus for manufacturing a carbon nano-tube tip comprising an AC/DC voltage supply, a metallic or semiconductor tip, an amperemeter, and a metallic vessel connected to the tip and the amperemter, wherein the metallic vessel is used as the electrode and define a groove therein filled with a carbon nano-tube solution. The present invention also provides a method for manufacturing a carbon nano-tube tip wherein carbon nano-tubes dispersed in a solvent are attached by electrophoresis to the end of a metal tip or semiconductor tip by using as an electrode a metallic vessel having a groove therein.

Abstract translation: 本发明提供了一种用于制造碳纳米管尖端的装置，其包括AC / DC电压源，金属或半导体尖端，安培计和连接到尖端和安培器的金属容器，其中金属容器用作 电极并且限定其中填充有碳纳米管溶液的槽。 本发明还提供一种碳纳米管尖端的制造方法，其中通过电极将分散在溶剂中的碳纳米管通过电极附着到金属尖端或半导体尖端的端部，该电极具有在其中具有凹槽的金属容器 。

公开(公告)号：US20080280891A1

公开(公告)日：2008-11-13

申请号：US11819494

申请日：2007-06-27

Applicant: Martha Kelly ,  Younghee Lee ,  Bin Liu ,  Ted Fujimoto ,  Joel Freundlich ,  Bruce D. Dorsey ,  Gary A. Flynn ,  Arifa Husain ,  William R. Moore, Jr.

Inventor： Martha Kelly ,  Younghee Lee ,  Bin Liu ,  Ted Fujimoto ,  Joel Freundlich ,  Bruce D. Dorsey ,  Gary A. Flynn ,  Arifa Husain ,  William R. Moore, Jr.

IPC: A61K31/541 ,  A61K31/404 ,  C07D209/42 ,  C07D401/02 ,  C07D417/14 ,  A61K31/44 ,  A61P35/00 ,  A61K31/4439 ,  A61K31/5377 ,  C07D413/14

CPC classification number: A61K31/404 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/541 ,  C07D213/74 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D413/12 ,  C07D498/04

Abstract: The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, prostate, non-small cell lung and colon. They are additionally useful in the treatment of proliferative retinopathies such as diabetic neuropathy and macular degeneration.

Abstract translation: 本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。 化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A 1是N或CR 1; N 3或N 3是N或CR 3; A <5>为N或CR 5; 在说明书中定义了R 1，R 3，R 6和L 6; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环 其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。 它们对广泛的癌症尤其是白血病，前列腺，非小细胞肺和结肠有效。 它们还可用于治疗增殖性视网膜病变，例如糖尿病性神经病变和黄斑变性。

公开(公告)号：US20080000773A1

公开(公告)日：2008-01-03

申请号：US11648033

申请日：2006-12-29

Applicant: Younghee Lee ,  Hakyu Choi ,  Seong Chu Lim

Inventor： Younghee Lee ,  Hakyu Choi ,  Seong Chu Lim

IPC: C25B7/00 ,  C25D1/12

CPC classification number: C25D1/12

Abstract: The present invention provides an apparatus for manufacturing a carbon nano-tube tip comprising an AC/DC voltage supply, a metallic or semiconductor tip, an amperemeter, and a metallic vessel connected to the tip and the amperemter, wherein the metallic vessel is used as the electrode and define a groove therein filled with a carbon nano-tube solution. The present invention also provides a method for manufacturing a carbon nano-tube tip wherein carbon nano-tubes dispersed in a solvent are attached by electrophoresis to the end of a metal tip or semiconductor tip by using as an electrode a metallic vessel having a groove therein.

Abstract translation: 本发明提供了一种用于制造碳纳米管尖端的装置，其包括AC / DC电压源，金属或半导体尖端，安培计和连接到尖端和安培器的金属容器，其中金属容器用作 电极并且限定其中填充有碳纳米管溶液的槽。 本发明还提供一种碳纳米管尖端的制造方法，其中通过电极将分散在溶剂中的碳纳米管通过电极附着到金属尖端或半导体尖端的端部，该电极具有在其中具有凹槽的金属容器 。