公开(公告)号：US09321764B2

公开(公告)日：2016-04-26

申请号：US14206028

申请日：2014-03-12

Applicant: AbbVie Inc.

Inventor： Le Wang ,  John Pratt ,  Lisa A. Hasvold ,  Dachun Liu ,  Yujia Dai ,  Steven D. Fidanze ,  James H. Holms ,  Robert A. Mantei ,  Keith F. McDaniel ,  George S. Sheppard ,  William J. McClellan

IPC: C07D401/04 ,  A61K31/4353 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, and R5 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4和R 5具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症的试剂 ，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：US09315488B2

公开(公告)日：2016-04-19

申请号：US14726337

申请日：2015-05-29

Applicant: AbbVie Inc.

Inventor： Hong Ding ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura A. Hexamer ,  Aaron R. Kunzer ,  William J. McClellan ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Michael D. Wendt

IPC: C07D295/155 ,  C07D209/08 ,  C07D211/58 ,  C07D401/12 ,  C07D309/04

CPC classification number: C07D401/12 ,  A61K31/407 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D209/32 ,  C07D211/58 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D241/04 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D295/155 ,  C07D309/04 ,  C07D309/14 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20140088106A1

公开(公告)日：2014-03-27

申请号：US14053544

申请日：2013-10-14

Applicant: AbbVie Inc.

Inventor： Milan Bruncko ,  Yujia Dai ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura A. Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Todd M. Hansen

IPC: C07D213/76 ,  A61K31/495 ,  A61K31/496 ,  C07D309/32 ,  C07D211/06 ,  C07D295/14 ,  C07D405/12 ,  C07D417/12 ,  A61K45/06 ,  C07D405/14 ,  A61K31/5377 ,  C07D403/12

CPC classification number: C07D213/76 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D211/06 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/14 ,  C07D295/30 ,  C07D309/04 ,  C07D309/32 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

公开(公告)号：US20140066621A1

公开(公告)日：2014-03-06

申请号：US13952278

申请日：2013-07-26

Applicant: The Walter and Eliza Hall Institute of Medical Research ,  AbbVie Inc.

Inventor： Milan Bruncko ,  Yujia Dai ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiahong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Peter Edward Czabotar ,  Guillaume Laurent Lessene ,  Peter Malcolm Colman ,  William J. McClellan

IPC: C07D401/12 ,  C07D211/58 ,  C07D309/08

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.