公开(公告)号：US20220017511A1

公开(公告)日：2022-01-20

申请号：US17183832

申请日：2021-02-24

Applicant: AbbVie Inc.

Inventor： Steven D. Fidanze ,  Lisa A. Hasvold ,  Dachun Liu ,  Keith F. McDaniel ,  John Pratt ,  Michael Schrimpf ,  George Sheppard ,  Le Wang ,  Bing Li

IPC: C07D471/04

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20210047304A1

公开(公告)日：2021-02-18

申请号：US16883713

申请日：2020-05-26

Applicant: AbbVie Inc.

Inventor： Marlon Cowart ,  Steven Fidanze ,  Lisa Hasvold ,  Dachun Liu ,  Keith McDaniel ,  John Pratt ,  George Sheppard ,  Le Wang

IPC: C07D405/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D487/10

Abstract: The present invention provides for compounds of formula (I) wherein R1, Y, L1, G1, X1, X2, L2, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US09050346B2

公开(公告)日：2015-06-09

申请号：US14203641

申请日：2014-03-11

Applicant: AbbVie Inc.

Inventor： Lisa A. Hasvold ,  Dachun Liu ,  Keith F. McDaniel ,  John Pratt ,  George S. Sheppard ,  Carol K Wada ,  Kevin R. Woller

IPC: C07D401/02 ,  C07D401/10 ,  A61K31/437 ,  A61K31/4353 ,  A61K31/5377 ,  C07D471/04 ,  A61K31/496 ,  A61K31/497 ,  C07D487/04 ,  A61K31/501 ,  A61K31/519

CPC classification number: A61K31/5377 ,  A61K31/437 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/463

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中R1，R2，A1，A2，A3，A4，X和Y具有说明书中定义的任何值及其药学上可接受的盐，其可用作 治疗疾病和病症，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：US20210253551A1

公开(公告)日：2021-08-19

申请号：US17100045

申请日：2020-11-20

Applicant: AbbVie Inc.

Inventor： Andrew Bogdan ,  Steven Fidanze ,  Keith McDaniel ,  John Pratt ,  Le Wang

IPC: C07D401/12 ,  C07D213/64 ,  C07D401/04

Abstract: The present invention provides for compounds of formula (I) wherein R1, Y, X1, X2, R2, R3, R4, R5, R6, and m have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20180298003A1

公开(公告)日：2018-10-18

申请号：US16018357

申请日：2018-06-26

Applicant: AbbVie Inc.

Inventor： Steven D. Fidanze ,  Dachun Liu ,  Robert A. Mantei ,  Keith F. McDaniel ,  John Pratt ,  George S. Sheppard ,  Le Wang ,  Andrew Bogdan ,  James H. Holms ,  Justin D. Dietrich ,  Jasmina Marjanovic ,  Lisa A. Hasvold ,  Yujia Dai

IPC: C07D471/22 ,  C07D471/16

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

公开(公告)号：US20160237084A1

公开(公告)日：2016-08-18

申请号：US15137502

申请日：2016-04-25

Applicant: AbbVie Inc.

Inventor： Le Wang ,  John Pratt ,  Lisa A. Hasvold ,  Dachun Liu ,  Yujia Dai ,  Steven D. Fidanze ,  James H. Holms ,  Robert A. Mantei ,  Keith F. McDaniel ,  George S. Sheppard ,  William J. McClellan

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, and R5 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4和R 5具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症的试剂 ，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：US20240360124A1

公开(公告)日：2024-10-31

申请号：US18516230

申请日：2023-11-21

Applicant: AbbVie Inc.

Inventor： Steven D. Fidanze ,  Lisa A. Hasvold ,  Dachun Liu ,  Keith F. McDaniel ,  John Pratt ,  Michael Schrimpf ,  George Sheppard ,  Le Wang ,  Bing Li

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides for compounds of formula (I)




wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20210070756A1

公开(公告)日：2021-03-11

申请号：US17099133

申请日：2020-11-16

Applicant: AbbVie Inc.

Inventor： Steven D. Fidanze ,  Dachun Liu ,  Robert A. Mantei ,  Keith F. McDaniel ,  John Pratt ,  George S. Sheppard ,  Le Wang ,  Andrew Bogdan ,  James H. Holms ,  Justin D. Dietrich ,  Jasmina Marjanovic ,  Lisa A. Hasvold ,  Yujia Dai

IPC: C07D471/22 ,  A61P15/16 ,  A61P31/18 ,  A61P13/12 ,  A61P35/00 ,  C07D471/16

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

公开(公告)号：US20200255426A1

公开(公告)日：2020-08-13

申请号：US16858930

申请日：2020-04-27

Applicant: AbbVie Inc.

Inventor： Steven D. Fidanze ,  Lisa A. Hasvold ,  Dachun Liu ,  Keith F. McDaniel ,  John Pratt ,  Michael Schrimpf ,  George Sheppard ,  Le Wang ,  Bing Li

IPC: C07D471/04

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20190389861A1

公开(公告)日：2019-12-26

申请号：US16254124

申请日：2019-01-22

Applicant: AbbVie Inc.

Inventor： Steven D. Fidanze ,  Dachun Liu ,  Robert A. Mantei ,  Keith F. McDaniel ,  John Pratt ,  George S. Sheppard ,  Le Wang ,  Andrew Bogdan ,  James H. Holms ,  Justin D. Dietrich ,  Jasmina Marjanovic ,  Lisa A. Hasvold ,  Yujia Dai

IPC: C07D471/22 ,  C07D471/16

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).