公开(公告)号：US20200255425A1

公开(公告)日：2020-08-13

申请号：US16858278

申请日：2020-04-24

Applicant: AbbVie Inc.

Inventor： Nathaniel Catron ,  Shuang Chen ,  Yuchuan Gong ,  Geoff G. Zhang

IPC: C07D471/04

Abstract: Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

公开(公告)号：US10730873B2

公开(公告)日：2020-08-04

申请号：US15806964

申请日：2017-11-08

Applicant: AbbVie Inc.

Inventor： Nathaniel Catron ,  Shuang Chen ,  Yuchuan Gong ,  Geoff G. Zhang

IPC: C07D471/04

Abstract: Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

公开(公告)号：US09359356B2

公开(公告)日：2016-06-07

申请号：US14622657

申请日：2015-02-13

Applicant: AbbVie Inc.

Inventor： Albert Wayne Kruger ,  Shuang Chen ,  Steven Cramer Cullen ,  James Joseph Napier

IPC: C07D221/22 ,  C07D471/18 ,  C07D285/12 ,  C07D285/135 ,  C07C249/02

CPC classification number: C07D471/18 ,  C07C249/02 ,  C07D285/12 ,  C07D285/135

Abstract: A compound, (4s)-1-azaadamantane-4yl formate ester, is described. In addition, a process is described for preparing (4s)-1-azaadamantane-4yl formate ester, aminothiadiazole-phenyl phosphate salt, bromothiadizole-phenyl or (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]-decane dihydrogen citrate. Furthermore, a process is described, comprising step of hydrolyzing (4s)-1-azaadamantane-4yl formate ester to form (4s)-1-azaadamantan-4-ol HBr salt.