公开(公告)号：US08969562B2

公开(公告)日：2015-03-03

申请号：US14204356

申请日：2014-03-11

Applicant: AbbVie Inc.

Inventor： Albert Wayne Kruger ,  Shuang Chen ,  Steven Cramer Cullen ,  James Joseph Napier

IPC: C07D285/135 ,  C07D285/12 ,  C07D471/18 ,  C07C249/02

CPC classification number: C07D471/18 ,  C07C249/02 ,  C07D285/12 ,  C07D285/135

Abstract: A compound, (4s)-1-azaadamantane-4yl formate ester, is described. In addition, a process is described for preparing (4s)-1-azaadamantane-4yl formate ester, aminothiadiazole-phenyl phosphate salt, bromothiadizole-phenyl or (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]-decane dihydrogen citrate. Furthermore, a process is described, comprising step of hydrolyzing (4s)-1-azaadamantane-4yl formate ester to form (4s)-1-azaadamantan-4-ol HBr salt.

Abstract translation: 描述了化合物（4s）-1-氮杂金刚烷-4-基甲酸酯。 此外，描述了制备（4s）-1-氮杂金刚烷-4-基甲酸酯，氨基噻二唑 - 苯基磷酸盐，溴噻嗪 - 苯基或（4s）-4-（5-苯基-1,3,4-噻二唑-2-基） 吡啶-2-基氧基）-1-氮杂三环[3.3.1.13.7] - 十二烷基二氢柠檬酸盐。 此外，描述了包括水解（4s）-1-氮杂金刚烷-4-基甲酸酯以形成（4s）-1-氮杂金刚烷-4-醇HBr盐的步骤。

公开(公告)号：US09359356B2

公开(公告)日：2016-06-07

申请号：US14622657

申请日：2015-02-13

Applicant: AbbVie Inc.

Inventor： Albert Wayne Kruger ,  Shuang Chen ,  Steven Cramer Cullen ,  James Joseph Napier

IPC: C07D221/22 ,  C07D471/18 ,  C07D285/12 ,  C07D285/135 ,  C07C249/02

CPC classification number: C07D471/18 ,  C07C249/02 ,  C07D285/12 ,  C07D285/135

Abstract: A compound, (4s)-1-azaadamantane-4yl formate ester, is described. In addition, a process is described for preparing (4s)-1-azaadamantane-4yl formate ester, aminothiadiazole-phenyl phosphate salt, bromothiadizole-phenyl or (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]-decane dihydrogen citrate. Furthermore, a process is described, comprising step of hydrolyzing (4s)-1-azaadamantane-4yl formate ester to form (4s)-1-azaadamantan-4-ol HBr salt.