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26 条记录 (耗时 0.046 秒)

    VARIANTS OF HEPATITIS B VIRUS WITH RESISTANCE TO ANTI-VIRAL NUCLEOSIDE AGENTS AND APPLICATIONS THEREOF
    21.
    发明申请
    VARIANTS OF HEPATITIS B VIRUS WITH RESISTANCE TO ANTI-VIRAL NUCLEOSIDE AGENTS AND APPLICATIONS THEREOF 有权
    乙型肝炎病毒对抗病毒核苷酸药物的抗性变异及其应用

    公开(公告)号：US20090130651A1

    公开(公告)日：2009-05-21

    申请号：US11911097

    申请日：2006-04-04

    申请人： Angeline Ingrid Bartholomeusz ,  Stephen Locarmini ,  Anna Ayres ,  Margaret Littlejohn ,  Paul Desmond ,  Peter William Angus

    发明人： Angeline Ingrid Bartholomeusz ,  Stephen Locarmini ,  Anna Ayres ,  Margaret Littlejohn ,  Paul Desmond ,  Peter William Angus

    IPC分类号： C12Q1/70 ,  C12N7/00

    CPC分类号： C07K14/005 ,  A61K2039/525 ,  A61K2039/5258 ,  C12N7/00 ,  C12N2730/10122 ,  C12Q1/706 ,  C12Q2600/156

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.

    摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。

    Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof
    22.
    发明授权
    Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof 有权
    具有抗病毒核苷剂抗性的乙型肝炎病毒的变体及其应用

    公开(公告)号：US08367317B2

    公开(公告)日：2013-02-05

    申请号：US12978289

    申请日：2010-12-23

    申请人： Angeline Ingrid Bartholomeusz ,  Stephen Logarnini ,  Anna Ayres ,  Margaret Littlejohn ,  Paul Desmond ,  Peter William Angus

    发明人： Angeline Ingrid Bartholomeusz ,  Stephen Logarnini ,  Anna Ayres ,  Margaret Littlejohn ,  Paul Desmond ,  Peter William Angus

    IPC分类号： A61K39/29 ,  A61K39/38 ,  C12Q1/00

    CPC分类号： C12N15/86 ,  A61K2039/525 ,  C07K14/005 ,  C12N7/00 ,  C12N2730/10122 ,  C12Q1/706

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.

    摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。

    VARIANTS OF HEPATITIS B VIRUS WITH RESISTANCE TO ANTI-VIRAL NUCLEOSIDE AGENTS AND APPLICATIONS THEREOF
    23.
    发明申请
    VARIANTS OF HEPATITIS B VIRUS WITH RESISTANCE TO ANTI-VIRAL NUCLEOSIDE AGENTS AND APPLICATIONS THEREOF 有权
    乙型肝炎病毒对抗病毒核苷酸药物的抗性变异及其应用

    公开(公告)号：US20110236422A1

    公开(公告)日：2011-09-29

    申请号：US12978289

    申请日：2010-12-23

    申请人： Angeline Ingrid Bartholomeusz ,  Stephen Logarnini ,  Anna Ayres ,  Margaret Littlejohn ,  Paul Desmond ,  Peter William Angus

    发明人： Angeline Ingrid Bartholomeusz ,  Stephen Logarnini ,  Anna Ayres ,  Margaret Littlejohn ,  Paul Desmond ,  Peter William Angus

    IPC分类号： A61K39/29 ,  C12N7/00 ,  C12Q1/70 ,  A61P31/20 ,  A61P37/04

    CPC分类号： C12N15/86 ,  A61K2039/525 ,  C07K14/005 ,  C12N7/00 ,  C12N2730/10122 ,  C12Q1/706

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.

    摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。