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公开(公告)号：US07038013B2
公开(公告)日：2006-05-02
申请号：US10002775
申请日：2001-11-02
IPC分类号： C07K14/47 , C07K14/725 , C07K16/46 , A61K38/17 , A61K39/395
CPC分类号： A61K45/06 , A61K39/00 , A61K2039/55516 , C07K14/70503 , C07K14/70532 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2319/30
摘要： The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的B7-4多肽的分离的核酸分子，命名为B7-4核酸分子。 本发明还提供反义核酸分子，含有B7-4核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了B7-4基因的非人转基因动物。 本发明还进一步提供分离的B7-4蛋白，融合蛋白，抗原肽和抗B7-4抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US06936704B1
公开(公告)日：2005-08-30
申请号：US09644934
申请日：2000-08-23
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/06 , A61P35/00 , A61P37/02 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/15 , G01N33/53 , C07H21/04 , C12N15/63 , C12N15/87
CPC分类号： A61K45/06 , A61K39/00 , A61K2039/55516 , C07K14/70503 , C07K14/70532 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2319/30
摘要： The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的B7-4多肽的分离的核酸分子，命名为B7-4核酸分子。 本发明还提供反义核酸分子，含有B7-4核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了B7-4基因的非人转基因动物。 本发明还进一步提供分离的B7-4蛋白，融合蛋白，抗原肽和抗B7-4抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US20050095593A1
公开(公告)日：2005-05-05
申请号：US10663497
申请日：2003-09-15
IPC分类号： A61K20060101 , C07K14/705 , C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/70503 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： A genetic locus and corresponding family of proteins associated with regulation of immune development, function, and cell survival are provided. The locus comprising the TIM family is genetically associated with immune dysfunction, including atopy, autoimmunity, inflammatory bowel disease, dysplasia, and susceptibility to blood-bourne infectious diseases. Polymorphisms in the human TIM-1 gene and exposure to Hepatitis A Virus (HAV) are shown to be associated with protection from the development of atopy.
摘要翻译： 提供了与调节免疫发育，功能和细胞存活相关的遗传基因座和相应的蛋白质家族。 包括TIM家族的基因座在遗传上与免疫功能障碍有关，包括特应性，自身免疫，炎性肠病，发育异常和对血液传染性疾病的易感性。 人TIM-1基因的多态性和甲型肝炎病毒（HAV）的暴露显示与保护免受特应性的发展有关。
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