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    Methods and systems for in situ tissue marking and orientation stabilization
    21.
    发明授权
    Methods and systems for in situ tissue marking and orientation stabilization 失效
    用于原位组织标记和取向稳定的方法和系统

    公开(公告)号：US07553310B2

    公开(公告)日：2009-06-30

    申请号：US10871790

    申请日：2004-06-17

    申请人： Roberta Lee ,  James W. Vetter ,  Ary S. Chernomorsky

    发明人： Roberta Lee ,  James W. Vetter ,  Ary S. Chernomorsky

    IPC分类号： A61B18/18

    CPC分类号： A61B10/0266 ,  A61B18/148 ,  A61B2018/00333 ,  A61B2018/00601 ,  A61B2018/141 ,  A61B2018/1475 ,  A61B2090/3908 ,  A61B2090/3937 ,  A61B2090/395

    摘要： A method of marking an orientation of a cut specimen of tissue prior to excision thereof from a body includes steps of disposing a tissue-marking probe in the body adjacent the cut specimen, the tissue-marking probe including a tissue-marking tool configured to selectively mark the cut specimen. A surface of the cut specimen is then marked with the tissue-marking tool such that the orientation of the cut specimen within the body is discernable after the cut specimen is excised from the body. The tissue-marking tool may be configured to selectively bow out of and back into a window defined near a distal tip of the probe and the marking step may include a step of selectively bowing the tissue-marking tool out of the window and following the surface of the cut specimen while rotating the probe. The tissue-marking tool may include an RF cutting tool and the marking step may include a step of coagulating or cauterizing a selected portion of the surface of the cut specimen with the RF cutting tool. Alternatively, the marking step may include a step of delivering dye onto selected portions of the surface of the cut specimen.

    摘要翻译： 在从身体切除之前标记组织切割样本的取向的方法包括以下步骤：将组织标记探针设置在与切割的样本相邻的身体中，组织标记探针包括组织标记工具，其被配置为选择性地 标记切割标本。 然后用组织标记工具标记切割的样品的表面，使得在切割的样品从身体切除之后，切割的样品在体内的取向是可辨别的。 组织标记工具可以被配置为选择性地弯曲到限定在探针的远侧末端附近的窗口中，并且标记步骤可以包括将组织标记工具选择性地弯曲出窗户并且跟随表面的步骤 同时旋转探头。 组织标记工具可以包括RF切割工具，并且标记步骤可以包括用RF切割工具凝固或烧灼切割样品表面的选定部分的步骤。 或者，标记步骤可以包括将染料递送到切割样品的表面的选定部分上的步骤。

    Methods and systems for in situ tissue marking and orientation stabilization
    24.
    发明授权
    Methods and systems for in situ tissue marking and orientation stabilization 失效
    用于原位组织标记和取向稳定的方法和系统

    公开(公告)号：US06780179B2

    公开(公告)日：2004-08-24

    申请号：US10155570

    申请日：2002-05-22

    申请人： Roberta Lee ,  James W. Vetter ,  Ary S. Chernomorsky

    发明人： Roberta Lee ,  James W. Vetter ,  Ary S. Chernomorsky

    IPC分类号： A61B1818

    CPC分类号： A61B10/0266 ,  A61B18/148 ,  A61B2018/00333 ,  A61B2018/00601 ,  A61B2018/141 ,  A61B2018/1475 ,  A61B2090/3908 ,  A61B2090/3937 ,  A61B2090/395

    摘要： A method of marking an orientation of a cut specimen of tissue prior to excision thereof from a body includes steps of disposing a tissue-marking probe in the body adjacent the cut specimen, the tissue-marking probe including a tissue-marking tool configured to selectively mark the cut specimen. A surface of the cut specimen is then marked with the tissue-marking tool such that the orientation of the cut specimen within the body is discernable after the cut specimen is excised from the body. The tissue-marking tool may be configured to selectively bow out of and back into a window defined near a distal tip of the probe and the marking step may include a step of selectively bowing the tissue-marking tool out of the window and following the surface of the cut specimen while rotating the probe. The tissue-marking tool may include an RF cutting tool and the marking step may include a step of coagulating or cauterizing a selected portion of the surface of the cut specimen with the RF cutting tool. Alternatively, the marking step may include a step of delivering dye onto selected portions of the surface of the cut specimen.

    摘要翻译： 在从身体切除之前标记组织切割样本的取向的方法包括以下步骤：将组织标记探针设置在与切割的样本相邻的身体中，组织标记探针包括组织标记工具，其被配置为选择性地 标记切割标本。 然后用组织标记工具标记切割的样品的表面，使得在切割的样品从身体切除之后，切割的样品在体内的取向是可辨别的。 组织标记工具可以被配置为选择性地弯曲到限定在探针的远侧末端附近的窗口中，并且标记步骤可以包括将组织标记工具选择性地弯曲出窗户并且跟随表面的步骤 同时旋转探头。 组织标记工具可以包括RF切割工具，并且标记步骤可以包括用RF切割工具凝固或烧灼切割样品表面的选定部分的步骤。 或者，标记步骤可以包括将染料递送到切割样品的表面的选定部分上的步骤。

    Methods and systems for marking post biopsy cavity sites
    25.
    发明授权
    Methods and systems for marking post biopsy cavity sites 失效
    用于标记活检后腔位点的方法和系统

    公开(公告)号：US07744852B2

    公开(公告)日：2010-06-29

    申请号：US11673510

    申请日：2007-02-09

    申请人： Ary S. Chernomorsky ,  Sean Chris Daniel ,  James W. Vetter

    发明人： Ary S. Chernomorsky ,  Sean Chris Daniel ,  James W. Vetter

    IPC分类号： A61K51/00 ,  A61K49/00 ,  A61K9/28 ,  A61K33/00

    CPC分类号： A61B90/39 ,  A61B2090/3908 ,  A61B2090/3925

    摘要： A method of marking a cavity in a breast for subsequent visualization may include steps of providing a device having a delivery opening, a first marker and a second marker, the first and second markers being movable through the delivery opening, the first marker being configured to be visualized by ultrasound and the second marker configured to be radiopaque, the first and second markers being free to move relative to one another; introducing the device into a breast so that the delivery opening is positioned in a cavity formed in the breast; and moving the first marker and the second marker through the delivery opening and into the cavity in the breast, the first and second markers being free to move relative to one another when delivered into the cavity so that the first and second markers may take a number of different positions relative to one another when positioned within the cavity.

    摘要翻译： 一种在乳房中标记腔体以便随后可视化的方法可以包括提供具有输送开口，第一标记和第二标记的装置的步骤，第一和第二标记可移动穿过输送开口，第一标记被配置为 通过超声可视化，第二标记被配置为不透射线，第一和第二标记物可相对于彼此自由移动; 将装置引入乳房，使得输送口位于形成在乳房中的空腔中; 以及通过所述输送开口移动所述第一标记和所述第二标记并进入所述乳房中的空腔中，所述第一标记和所述第二标记在递送到所述空腔中时相对于彼此自由移动，使得所述第一标记和所述第二标记可以取数 当位于空腔内时相对于彼此的不同位置。

    METHODS AND DEVICES FOR CUTTING AND COLLECTING SOFT TISSUE
    26.
    发明申请
    METHODS AND DEVICES FOR CUTTING AND COLLECTING SOFT TISSUE 审中-公开
    用于切割和收集软组织的方法和装置

    公开(公告)号：US20080140067A1

    公开(公告)日：2008-06-12

    申请号：US11836018

    申请日：2007-08-08

    申请人： James W. Vetter ,  Ary S. Chernomorsky ,  Mark J. Clifford ,  Dan Brounstein ,  Scott C. Anderson

    发明人： James W. Vetter ,  Ary S. Chernomorsky ,  Mark J. Clifford ,  Dan Brounstein ,  Scott C. Anderson

    IPC分类号： A61B18/18

    CPC分类号： A61B10/0266 ,  A61B2017/00287 ,  A61B2017/008 ,  A61B2018/1407

    摘要： A device for cutting and collecting a specimen from a mass of tissue may include a shaft, an integrated cut and collect assembly coupled to the shaft and an actuator. The shaft may define an opening and may include an outer surface that defines a trough adjacent the opening, the trough defining a ledge portion that is cut out of the shaft. The integrated cut and collect assembly may include an RF cutting portion and a collection portion that includes a flexible membrane, the collection portion being attached to the cutting portion, the integrated cut and collect assembly being configured to assume a retracted position at least partially within the opening such that part of the collection portion is disposed within the trough and in contact with the ledge portion and a selectable expanded position that extends through the opening and away from the shaft. The cutting portion may be configured to cut the specimen from the mass of tissue and the collection portion may be configured to collect the cut specimen and to isolate the cut specimen within the membrane. The trough may be configured to minimize contact of the cutting portion with the tissue to be cut as the cutting portion is becoming fully energized in the retracted position. The actuator may be coupled to the integrated assembly such that operation of the actuator causes a deployment of the integrated assembly from the retracted position to the selectable expanded position.

    摘要翻译： 用于从大量组织切割和收集试样的装置可以包括轴，与轴连接的集成切割和收集组件和致动器。 轴可以限定开口并且可以包括限定靠近开口的槽的外表面，所述槽限定从轴切出的凸缘部分。 集成的切割和收集组件可以包括RF切割部分和收集部分，其包括柔性膜，收集部分附接到切割部分，集成切割和收集组件被配置为呈现至少部分地在 开口使得收集部分的一部分设置在槽内并与凸缘部分接触，并且可选择的扩展位置延伸穿过开口并远离轴。 切割部分可以被配置为从组织块切割样本，并且收集部分可以被配置为收集切割的样品并将切割的样品隔离在膜内。 槽可以被配置为当切割部分在缩回位置变得完全通电时使切割部分与要切割的组织的接触最小化。 致动器可以联接到集成组件，使得致动器的操作使得整合组件从缩回位置展开到可选择的扩展位置。

    Excisional biopsy devices and methods
    29.
    发明授权
    Excisional biopsy devices and methods 失效
    切除活检装置和方法

    公开(公告)号：US06689145B2

    公开(公告)日：2004-02-10

    申请号：US10066428

    申请日：2002-01-31

    申请人： Roberta Lee ,  James W. Vetter ,  Ary S. Chernomorsky

    发明人： Roberta Lee ,  James W. Vetter ,  Ary S. Chernomorsky

    IPC分类号： A61B1732

    CPC分类号： A61B10/0266 ,  A61B10/0041 ,  A61B10/02 ,  A61B10/04 ,  A61B17/320725 ,  A61B18/1482 ,  A61B2018/00011 ,  A61B2018/00333 ,  A61B2018/1407 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2090/3784 ,  A61B2218/002

    摘要： An excisional biopsy system includes a tubular member that has a proximal end and a distal end in which one or more windows are defined. A first removable probe has a proximal portion that includes a cutting tool extender and a distal portion that includes a cutting tool. The first removable probe may be configured to fit at least partially within the tubular member to enable the cutting tool to selectively bow out of and to retract within one of the windows when the cutting tool extender is activated. A second removable probe has a proximal section that includes a tissue collection device extender and a distal section that includes a tissue collection device. The second removable probe may also be configured to fit at least partially within the tubular member to enable the tissue collection device to extend out of and to retract within one of the windows when the tissue collection device extender is activated. A third removable probe may also be provided. The third removable probe may also be configured to fit at least partially within the tubular member and may include an imaging device, such as an ultrasound transducer, mounted therein. By selectively activating the cutting tool and the tissue collection device while rotating the excisional device, a tissue specimen may be cut from the surrounding tissue and collected for later analysis.

    摘要翻译： 切除活检系统包括管状构件，其具有限定一个或多个窗口的近端和远端。 第一可移除探针具有近端部分，其包括切削刀具延伸器和包括切削工具的远端部分。 第一可移除探针可以被配置为至少部分地配合在管状构件内，以使得当切割工具延伸器被激活时，切割工具能够选择性地弯曲在一个窗口内并缩回。 第二可移除探针具有近端部分，其包括组织收集装置延伸器和包括组织收集装置的远端部分。 第二可移除探针也可以被配置为至少部分地配合在管状构件内，以使组织收集装置在组织收集装置延伸器被启动时延伸出窗口内的一个窗口并缩回。 还可以提供第三可移除探针。 第三可移除探针也可以被配置为至少部分地配合在管状构件内，并且可以包括安装在其中的成像装置，例如超声换能器。 通过在旋转切除装置的同时选择性地激活切割工具和组织收集装置，可以从周围组织切割组织标本并收集用于随后的分析。

    Process and apparatus for harvesting tissue for processing tissue and process and apparatus for re-injecting processed tissue
    30.
    发明授权
    Process and apparatus for harvesting tissue for processing tissue and process and apparatus for re-injecting processed tissue 失效
    用于收集用于加工组织的组织的方法和装置以及用于再注射经处理的组织的方法和装置

    公开(公告)号：US5827217A

    公开(公告)日：1998-10-27

    申请号：US708307

    申请日：1996-09-04

    申请人： Frederick H. Silver ,  Ary S. Chernomorsky

    发明人： Frederick H. Silver ,  Ary S. Chernomorsky

    IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/16 ,  A61F2/46 ,  A61L27/36

    CPC分类号： A61L27/3683 ,  A61B17/1637 ,  A61F2/4601 ,  A61B10/0233 ,  A61B2017/0046 ,  A61B2017/00969 ,  A61F2002/4635 ,  A61F2002/4649

    摘要： There is disclosed a method and apparatus for harvesting tissue using a cannula having a diameter of from 0.5 to 4.0 mm and of a length of from 25 to 20 cm to access by minimally invasive techniques a host to withdraw autogenous tissue processed to remove loose fat and/or fragmented tissue. Thereafter, the resulting tissue substrate is morcellated to form particulate tissue of a particle size of from 1 to 200 .mu.m. The particulate material is thence passed through screens having opening sizes of from 1 to 100 .mu.m to form a material of a size for introduction into a syringe of from 16 to 30 gauge for implantation in the host. The processed tissue may be admixed with extenders, gelling agents and the like.

    摘要翻译： 公开了一种使用直径为0.5至4.0mm且长度为25至20cm的套管收集组织的方法和装置，以通过微创技术获得主机以撤回被处理以除去松散脂肪的自体组织， /或碎片组织。 然后，将得到的组织基板脱模，形成粒径为1〜200μm的微粒组织。 然后将颗粒材料通过具有1至100μm的开口尺寸的筛网，以形成用于引入到注射器中的尺寸为16至30的尺寸的材料，用于植入宿主体内。 经加工的组织可以与增量剂，胶凝剂等混合。