利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.029 秒)

    Imidazoisoquinoline compounds useful as anti-ulcerative agents
    25.
    发明授权
    Imidazoisoquinoline compounds useful as anti-ulcerative agents 失效
    咪唑并异喹啉化合物可用作抗溃疡剂

    公开(公告)号：US4686227A

    公开(公告)日：1987-08-11

    申请号：US745638

    申请日：1985-06-17

    申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Masayuki Kato ,  Nobukiyo Konishi ,  Atsushi Akahane

    发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Masayuki Kato ,  Nobukiyo Konishi ,  Atsushi Akahane

    IPC分类号： C07D471/04 ,  A61K31/47 ,  A61P1/04 ,  C07D487/04 ,  A61K31/395 ,  C07D405/04

    CPC分类号： C07D487/04

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.3 is hydrogen, halogen or ar(lower)alkoxy, andR is lower alkanoyl, nitroso, amino, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, haloformyl, aminomethyleneamino which may be substituted with cyano or lower alkyl, iminomethylamino which may be substituted with cyano or lower alkyl, or a group of the formula: --A--R.sup.2 in whichA is lower alkylene andR.sup.2 is di(lower)alkylamino, cyano, lower alkoxy, N-containing heterocyclic group which may have suitable substituent(s), lower alkynyloxy, lower alkenyloxy, lower alkylthio, amino(lower)alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, hydroxy, lower alkanoyloxy, heterocyclicamino (lower)alkylthio having two oxo groups, hydrogen or a group of the formula: ##STR2## in which R.sup.4, R.sup.5 and R.sup.6 are each lower alkyl andX is an acid residue,and pharmaceutically acceptable salts thereof.The compounds are useful as anti ulcer agents.

    摘要翻译： 下式的化合物，其中R 1为低级烷基，R 3为氢，卤素或芳（低级）烷氧基，R为低级烷酰基，亚硝基，氨基，羧基，酯化羧基，氨基甲酰基，羟基氨基甲酰基，卤代甲酰基，氨基亚甲基氨基 可以被氰基或低级烷基取代，可以被氰基或低级烷基取代的亚氨基甲基氨基，或下列基团：其中A是低级亚烷基，R2是二（低级）烷基氨基，氰基，低级烷氧基 ，可具有适当取代基的含N杂环基，低级炔氧基，低级烯氧基，低级烷硫基，氨基（低级）烷硫基，低级烷基亚磺酰基，低级烷基磺酰基，羧基，酯化羧基，氨基甲酰基，羟基氨基甲酰基，羟基，低级烷酰氧基， 具有两个氧代基的杂环氨基（低级）烷硫基，氢或下式的基团：其中R 4，R 5和R 6各自为低级烷基，X为酸残基，及其药学上可接受的盐。 该化合物可用作抗溃疡剂。

    .alpha.-Aryl-.alpha.-pyridylalkanoic acid derivatives, process for preparation thereof and pharmaceutical composition comprising the same
    26.
    发明授权
    .alpha.-Aryl-.alpha.-pyridylalkanoic acid derivatives, process for preparation thereof and pharmaceutical composition comprising the same 失效
    α-亚氨基-α-吡啶基链烷酸衍生物，其制备方法和包含其的药物组合物

    公开(公告)号：US4564621A

    公开(公告)日：1986-01-14

    申请号：US535298

    申请日：1983-09-23

    申请人： Ikuo Ueda ,  Masanobu Nagano ,  Atsushi Akahane

    发明人： Ikuo Ueda ,  Masanobu Nagano ,  Atsushi Akahane

    IPC分类号： C07D401/12 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61P1/04 ,  C07D213/56 ,  C07D213/57 ,  C07D213/38

    CPC分类号： C07D213/57 ,  C07D213/56

    摘要： New .alpha.-aryl-.alpha.-pyridylalkanoic acid derivatives of the formula: ##STR1## wherein R.sup.1 is cyano or carbamoyl,R.sup.2 is hydrogen or halogen,R.sup.3 is hydrogen or lower alkyl,one of R.sup.4 and R.sup.5 is hydrogen and another is lower alkyl,R.sup.6 is hydrogen or lower alkyl, andR.sup.7 is lower alkyl, orR.sup.6 and R.sup.7 are taken together to form an N-containing saturated heterocyclic group with the adjacent nitrogen atom, in which the heterocyclic group may be substituted with lower alkyl or optionally protected hydroxy(lower)alkyl,provided that R.sup.2 is halogen or R.sup.3 is lower alkyl, when R.sup.1 is cyano and R.sup.6 and R.sup.7 are each lower alkyl, and salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents and spasmolytic agents.

    摘要翻译： 新颖的下式的α-芳基-α-吡啶基链烷酸衍生物：其中R 1是氰基或氨基甲酰基，R 2是氢或卤素，R 3是氢或低级烷基，R 4和R 5之一是氢，另一个是低级烷基， R6是氢或低级烷基，R7是低级烷基，或R6和R7一起形成含有相邻氮原子的含氮饱和杂环基，其中杂环基可以被低级烷基或任选被保护的羟基取代 （低级）烷基，条件是当R 1为氰基且R 6和R 7为低级烷基时，R 2为卤素或R 3为低级烷基，及其盐及其制备方法和包含其的药物组合物。 这些衍生物和其盐可用作抗溃疡剂和溶解裂解剂。