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公开(公告)号：US5234930A
公开(公告)日：1993-08-10
申请号：US866215
申请日：1992-04-09
IPC分类号： A61K31/435 , A61K31/437 , A61K31/445 , A61K31/4545 , A61P3/04 , A61P3/06 , A61P7/02 , A61P7/10 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P19/06 , A61P25/04 , A61P25/24 , A61P25/26 , A61P25/28 , A61P37/06 , C07D221/00 , C07D231/00 , C07D471/04
CPC分类号： C07D471/04
摘要： This invention relates to pyrazolopyridine compounds for the treatment of melancholia, heart failure, hypertension, renal insufficiency, renal toxicity, nephrosis, nephritis, edema, obesity, bronchial asthma, gout, hyperuricemia, sudden infant death syndrome, immunosuppression, diabetes, myocardial infarction, thrombosis, obstruction, arteriosclerosis obliterans, thrombophlebitis, cerebral infarction, transient ischemic attack or angina pectoris, said compounds being of the formula ##STR1## wherein the radicals are defined in the claims.
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公开(公告)号：US5296490A
公开(公告)日：1994-03-22
申请号：US968664
申请日：1992-10-30
IPC分类号： A61K31/435 , A61P7/02 , A61P7/10 , A61P9/04 , A61P9/12 , A61P13/02 , A61P15/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The disclosure concerns pyrazolopyridine compounds of the formulawherein the variables are defined in the specification. The compounds are useful as a diuretic, anti-hypertensive agent, etc.
摘要翻译： 本公开涉及下式的吡唑并吡啶化合物，其中变量在说明书中定义。 该化合物可用作利尿剂，抗高血压剂等。
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公开(公告)号：US4925849A
公开(公告)日：1990-05-15
申请号：US202526
申请日：1988-06-06
IPC分类号： A61K31/435 , A61P7/02 , A61P7/10 , A61P9/04 , A61P9/12 , A61P13/02 , A61P15/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The disclosure deals with a pyrazolopyridine compound of the formula ##STR1## wherein the variables are defined in the specification. The compounds are useful as a diuretic, antihypertensive agent, etc.
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公开(公告)号：US5338743A
公开(公告)日：1994-08-16
申请号：US847286
申请日：1992-03-10
IPC分类号： A61K31/44 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/52 , A61K31/535 , A61K31/55 , C07D471/04 , C07D473/02 , A61K31/33 , A61K31/395 , A61K31/435 , A61K31/53 , A61K31/54
CPC分类号： C07D471/04 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/52 , A61K31/535 , A61K31/55 , C07D473/02
摘要： The present method for the treatment of pancreatitis, which comprises administering an effective amount of a pyrazolopyridine compound of the following formula: ##STR1## wherein R.sup.1 is lower alkyl, (substituted) aryl, or a heterocyclic group,R.sup.2 is a group of the formula ##STR2## wherein R.sup.4 is protected amino or hydroxy and R.sup.5 is hydrogen or lower alkyl; cyano; a group of the formula --A--R.sup.6, wherein R.sup.6 is an acyl group, and A is (halogenated) lower aliphatic hydrocarbon group; amidated carboxy; an unsaturated heterocyclic group; or (protected) amino; andR.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen; or a pharmaceutically acceptable salt thereof, to a human being having pancreatitis or an animal having pancreatitis in need thereof.
摘要翻译： 本发明的治疗胰腺炎的方法包括给予有效量的下式的吡唑并吡啶化合物：其中R1是低级烷基，（取代的）芳基或杂环基，R2是式 其中R 4是保护的氨基或羟基，R 5是氢或低级烷基; 氰基; 式-A-R6的基团，其中R6是酰基，A是（卤代）低级脂族烃基; 酰胺羧基; 不饱和杂环基; 或（保护）氨基; 并且R 3是氢，低级烷基，低级烷氧基或卤素; 或其药学上可接受的盐对具有胰腺炎的人或具有需要的胰腺炎的动物。
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公开(公告)号：US5102878A
公开(公告)日：1992-04-07
申请号：US495799
申请日：1990-03-19
IPC分类号： A61K31/435 , A61P7/02 , A61P7/10 , A61P9/04 , A61P9/12 , A61P13/02 , A61P15/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to a method for the treatment of ailments which comprises administering an effective amount of the pyrazolopyridine compounds of the invention.
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公开(公告)号：US5155114A
公开(公告)日：1992-10-13
申请号：US715460
申请日：1991-06-14
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04
摘要： The invention relates to a method for the prevention and/or treatment of renal toxicity, nephrosis or nephritis, which comprises administering a pyrazolopyridine compound of the formula: ##STR1## wherein R.sup.1 is aryl, andR.sup.2 is unsaturated heterocyclic group which contains at least one heteroatom selected from the group consisting of N, O and S, which may have one or more suitable substituent(s), or a pharmaceutically acceptable salt thereof to a human being or an animal.
摘要翻译： 本发明涉及一种用于预防和/或治疗肾毒性，肾病或肾炎的方法，其包括施用下式的吡唑并吡啶化合物：其中R1是芳基，R2是不饱和杂环基，其含有至少一个 选自N，O和S的杂原子，其可以具有一个或多个合适的取代基或其药学上可接受的盐给人或动物。
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公开(公告)号：US4985444A
公开(公告)日：1991-01-15
申请号：US466929
申请日：1990-01-18
IPC分类号： A61K31/435 , A61K31/437 , A61K31/44 , A61K31/50 , A61K31/505 , A61P3/06 , A61P7/02 , A61P7/10 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P19/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P29/00 , A61P43/00 , C07D471/04 , C07D513/04 , C07D519/00 , C07D521/00
CPC分类号： C07D471/04
摘要： The invention relates to pyrazolopyridine compounds for the treatment of melancholia, heart failure, hypertension, renal insufficiency, edema, obesity, bronchial asthma, gout, hyperuricemia, sudden infant death syndrome, immunosuppression, diabetes, myocardiac infection, thrombosis, obstruction, arteriosclerosis obliterans, thrombophlebitis, cerebral infarction, transient ischemic attack or angina pectoris, said compounds being of the formula ##STR1## wherein R.sup.1 is aryl, andR.sup.2 is unsaturated heterocyclic group which contains at least one heteroatom selected from the group consisting of N, O and S, which may have one or more suitable substituent(s),or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US5204346A
公开(公告)日：1993-04-20
申请号：US729688
申请日：1991-07-15
IPC分类号： A61K31/435 , A61K31/501 , A61P1/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P7/02 , A61P7/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P19/06 , A61P25/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P37/04 , A61P43/00 , C07D471/04
CPC分类号： C07D471/04
摘要： There are disclosed 3 [2(substituted alkyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-aryl pyrazolo [1,5-a]-pyridines useful for treating maladies requiring an adenosine antagonist, and preparative processes.
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公开(公告)号：US5179103A
公开(公告)日：1993-01-12
申请号：US793937
申请日：1991-10-22
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The disclosure deals with pyrazolopyridine compounds of the formula: ##STR1## wherein the variables are defined in the specification. The compounds are useful as a diuretic, anti-hypertensive agent, etc.
摘要翻译： 本公开涉及下式的吡唑并吡啶化合物：其中变量在说明书中定义。 该化合物可用作利尿剂，抗高血压剂等。
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公开(公告)号：US5102869A
公开(公告)日：1992-04-07
申请号：US540325
申请日：1990-06-19
IPC分类号： A61K31/435 , A61P7/02 , A61P7/10 , A61P9/04 , A61P9/12 , A61P13/02 , A61P15/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to a method for the treatment of renal toxicity, nephrosis or nephritis which comprises administering an effective amount of the pyrazolopyridine compounds of the invention.
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