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    Osmotic device for delayed delivery of agent
    23.
    发明授权
    Osmotic device for delayed delivery of agent 失效
    用于延迟递送药剂的渗透装置

    公开(公告)号：US5312388A

    公开(公告)日：1994-05-17

    申请号：US830160

    申请日：1992-01-31

    申请人： Patrick S.-L. Wong ,  Felix Theeuwes ,  Steven D. Larsen

    发明人： Patrick S.-L. Wong ,  Felix Theeuwes ,  Steven D. Larsen

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/48

    CPC分类号： A61K9/0004 ,  A61K9/4808

    摘要： The present invention is directed to a fluid-imbibing dispensing device for the immediate or almost immediate and extended delivery of an active agent over a prolonged period of time together with the initially delayed pulse delivery of an active agent to a fluid environment of use. The dispenser comprises a housing having a first wall section and a second wall section in slidably telescoping arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; a first active agent delivery chamber within a portion of the compartment defined by the first wall section, the first delivery chamber including at least one active agent formulation, an exit means for providing communication between the active agent formulation and the environment, and a first expansion means for dispensing the first active agent formulation through the exit means to the environment immediately and over a prolonged period of time; a second active agent delivery chamber within a portion of the compartment defined by the first wall section and adjacent the open end of the first wall section, the second delivery chamber including at least one active agent formulation; and an expansion chamber within a portion of the compartment defined by the second wall section, for separating apart the first and second wall sections of the housing after exposure to the environment of use for dispensing the second active agent formulation to the environment in a pulse after an initially delayed period of time, the expansion chamber including a second expansion means and a partition layer or push plate.

    摘要翻译： 本发明涉及一种流体吸入分配装置，用于在延长的时间段内立即或几乎立即和延长地递送活性剂，同时将活性剂的初始延迟脉冲输送到使用的流体环境。 分配器包括具有彼此可滑动地伸缩布置的第一壁部分和第二壁部分的壳体，该壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 第一活性剂递送室，位于由第一壁部限定的隔室的一部分内，第一递送室包括至少一种活性剂制剂，用于提供活性剂配方与环境之间的连通的出口装置，以及第一膨胀 用于通过出口装置将第一活性剂制剂直接和长时间地分配到环境的装置; 第二活性剂递送室，其在由第一壁部分限定并且邻近第一壁部分的开口端限定的隔室的一部分内，第二递送室包括至少一种活性剂制剂; 以及在由所述第二壁部限定的所述隔室的一部分内的膨胀室，用于在暴露于使用环境之后分离所述壳体的所述第一和第二壁部分，以在所述第二活性剂配方的环境中以脉冲分配所述环境 最初延迟的时间段，膨胀室包括第二膨胀装置和分隔层或推板。