公开(公告)号：US20160318935A1

公开(公告)日：2016-11-03

申请号：US15103756

申请日：2014-12-11

Applicant: BIOGEN MA INC. ,  SUNESIS PHARMACEUTICALS, INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Gnanasambandam Kumaravel ,  Hua Miao ,  Andrea Bertolotti-Ciarlet ,  Kevin Otipoby

IPC: C07D487/04 ,  G01N33/573 ,  C07D513/04 ,  C07D473/00 ,  C07D519/00 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D473/00 ,  C07D513/04 ,  C07D519/00 ,  G01N33/573 ,  G01N2333/9121

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract translation: 本发明提供了可用作Bruton酪氨酸激酶抑制剂的化合物及其组合物，其表现出所需特性。

公开(公告)号：US20160311802A1

公开(公告)日：2016-10-27

申请号：US15103749

申请日：2014-12-11

Applicant: Biogen MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07D495/04 ,  C07D409/14 ,  C07D487/04 ,  C07D513/04 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D401/14

CPC classification number: C07D403/12 ,  A61K31/506 ,  C07D239/30 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/027

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract translation: 本发明提供了可用作Bruton酪氨酸激酶抑制剂的化合物及其组合物，并且其表现出所需特性。

公开(公告)号：US20240083900A1

公开(公告)日：2024-03-14

申请号：US18036853

申请日：2021-11-12

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Isaac Marx ,  Jürgen Schulz ,  George Vandeveer ,  Robin Prince ,  Marta Nevalainen ,  TeYu Chen ,  Zain Yousaf ,  Martin Himmelbauer ,  Vatee Pattaropong ,  John Howard Jones ,  Edward Yin-Shiang Lin ,  Felix Gonzalez Lopez de Turiso ,  Thomas Purgett ,  Andrew George Capacci ,  Simone Sciabola

IPC: C07D487/04 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: Provided are compounds of Formula (I′): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

公开(公告)号：US20210340135A1

公开(公告)日：2021-11-04

申请号：US17183702

申请日：2021-02-24

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC: C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  A61P43/00 ,  C07D405/14 ,  C07D471/04 ,  A61P1/16

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US10189817B2

公开(公告)日：2019-01-29

申请号：US15875629

申请日：2018-01-19

Applicant: BIOGEN MA INC. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Xiongwei Cai ,  Timothy R. Chan ,  Patrick Conlon ,  Michael Humora ,  Tracy J. Jenkins ,  J. Michael Macphee ,  Xianglin Shi ,  Ross A. Miller ,  Andrew Thompson

IPC: C07D401/14 ,  C07D401/04 ,  C07D211/56 ,  C07D207/28 ,  C07D207/16

Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

公开(公告)号：US20180362522A1

公开(公告)日：2018-12-20

申请号：US16113455

申请日：2018-08-27

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC: C07D417/14 ,  A61P43/00 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D417/14 ,  A61K31/44 ,  A61K31/443 ,  A61K31/506 ,  A61P43/00 ,  C07B2200/13 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US09944622B2

公开(公告)日：2018-04-17

申请号：US15196389

申请日：2016-06-29

Applicant: Biogen MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Timothy R. Chan ,  Tracy J. Jenkins ,  Patrick Conlon ,  Xiongwei Cai ,  Michael Humora ,  Xianglin Shi ,  Ross A. Miller ,  Andrew Thompson

IPC: A61K31/506 ,  C07D401/14

CPC classification number: C07D401/14

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US09809577B2

公开(公告)日：2017-11-07

申请号：US15103749

申请日：2014-12-11

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07D417/14 ,  C07D495/04 ,  C07D409/14 ,  C07D401/14 ,  C07D513/04 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04

CPC classification number: C07D403/12 ,  A61K31/506 ,  C07D239/30 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/027

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US20170114039A1

公开(公告)日：2017-04-27

申请号：US15167508

申请日：2016-05-27

Applicant: Biogen MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Xiongwei Cai ,  Timothy R. Chan ,  Patrick Conlon ,  Michael Humora ,  Tracy J. Jenkins ,  J. Michael Macphee ,  Xianglin Shi ,  Ross A. Miller ,  Andrew Thompson

IPC: C07D401/14 ,  C07D401/04 ,  C07D207/16 ,  C07D211/56 ,  C07D207/28

CPC classification number: C07D401/14 ,  C07B2200/13 ,  C07D207/16 ,  C07D207/28 ,  C07D211/56 ,  C07D401/04

Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

公开(公告)号：US20160304494A1

公开(公告)日：2016-10-20

申请号：US15196389

申请日：2016-06-29

Applicant: Biogen MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Timothy R. Chan ,  Tracy J. Jenkins ,  Patrick Conlon ,  Xiongwei Cai ,  Michael Humora ,  Xianglin Shi ,  Ross A. Miller ,  Andrew Thompson

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.