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公开(公告)号：US09809577B2
公开(公告)日：2017-11-07
申请号：US15103749
申请日：2014-12-11
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D417/14 , C07D495/04 , C07D409/14 , C07D401/14 , C07D513/04 , C07D413/14 , C07D417/12 , C07D487/04
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US20230060003A1
公开(公告)日：2023-02-23
申请号：US17772646
申请日：2020-10-28
Applicant: BIOGEN MA INC.
Inventor： Nathan Genung , Kevin M. Guckian , Lei Zhang , Zhili Xin , Jeffrey Vessels , Ryan Gianatassio
IPC: C07D491/107 , C07D491/20 , C07D417/06
Abstract: Described herein are compounds represented by formula (I) or formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables R1, R2, R3, R4, R5, R6, Y1, Y2, D, E, G1, G2, n and p are as defined herein.
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公开(公告)号：US20220332705A1
公开(公告)日：2022-10-20
申请号：US17004411
申请日：2020-08-27
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , A61K31/506 , C07D239/30 , C07F5/02 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , C07D487/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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Patent Agency Ranking
公开(公告)号：US20220259197A1
公开(公告)日：2022-08-18
申请号：US17435125
申请日：2020-03-06
Applicant: BIOGEN MA INC.
Inventor： Nathan Genung , Kevin M. Guckian , Jeffrey Vessels , Lei Zhang , Ryan Gianatassio , Edward Yin Shiang Lin , Zhili Xin
IPC: C07D417/14 , C07D495/04
Abstract: Described herein are compounds represented by formula (I) (I) or a pharmaceutically acceptable salt thereof, pharmaceutical comositions comprising the same and methods of preparing and using the same. The variables Ar, X, R1, R3, R4, Y1, Y2, and Z are as defined herein.
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公开(公告)号：US20210040080A1
公开(公告)日：2021-02-11
申请号：US16978550
申请日：2019-03-13
Applicant: BIOGEN MA INC.
Inventor： Nathan Genung , Kevin M. Guckian , Jeffrey Vessels , Lei Zhang , Ryan Gianatassio , Edward Yin Shiang Lin , Zhili Xin
IPC: C07D417/14 , C07D471/04 , C07D417/06
Abstract: Described herein are compounds represented by formula (I″) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, Ra, Rb, m, n, Y1, Y2, R3 and R4 are defined herein.
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公开(公告)号：US10759783B2
公开(公告)日：2020-09-01
申请号：US16108755
申请日：2018-08-22
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D417/14 , C07D495/04 , C07D409/14 , C07D401/14 , C07D513/04 , C07D413/14 , A61K31/506 , C07D239/30 , C07F5/02 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US10017506B2
公开(公告)日：2018-07-10
申请号：US15296601
申请日：2016-10-18
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/015 , A61K31/4375 , A61K31/44 , C07D451/02 , C07D217/22 , A61K31/472 , A61K45/06 , A61K31/4725 , C07D401/06
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
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28.发明授权公开(公告)号：US09550798B2
公开(公告)日：2017-01-24
申请号：US14417293
申请日：2013-07-26
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Zhili Xin , Lei Zhang
IPC: C07C229/48 , C07D223/06 , C07D221/22 , C07D209/52 , C07D211/62 , C07D295/096 , A61K31/5375 , A61K31/439 , A61K31/46 , A61K31/445 , A61K31/196 , A61K31/136 , C07F7/08 , A61K45/06 , A61K31/195 , A61K31/41 , A61K31/4709 , A61K31/4725 , A61K31/5513 , C07D215/38 , C07D217/22 , C07D401/04 , C07D471/08 , C07C217/58 , C07C229/46 , C07C233/61 , C07C235/66 , A61K31/397 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/695 , C07C211/38 , C07D205/04 , C07D213/74 , C07D215/20 , C07D401/06
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。
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